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Improving emotion regulation of social exclusion in depression-prone individuals: a tDCS study targeting right VLPFC

Published online by Cambridge University Press:  16 October 2019

Zhenhong He ,
Zhenli Liu ,
Jun Zhao ,
Rebecca Elliott  and
Dandan Zhang
Zhenhong He
Affiliation:
College of Psychology, Shenzhen University, Shenzhen518060, China Division of Neuroscience and Experimental Psychology, School of Biological Science, University of Manchester, ManchesterM13 9PL, UK
Zhenli Liu
Affiliation:
College of Psychology, Shenzhen University, Shenzhen518060, China
Jun Zhao
Affiliation:
College of Psychology, Shenzhen University, Shenzhen518060, China
Rebecca Elliott
Affiliation:
Division of Neuroscience and Experimental Psychology, School of Biological Science, University of Manchester, ManchesterM13 9PL, UK
Dandan Zhang*
Affiliation:
College of Psychology, Shenzhen University, Shenzhen518060, China Shenzhen Key Laboratory of Affective and Social Cognitive Science, Shenzhen University, Shenzhen518060, China
*
Author for correspondence: Dandan Zhang, E-mail: zhangdd05@gmail.com
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Abstract

Background

Growing evidence has indicated that right ventrolateral prefrontal cortex (RVLPFC) is critical in down-regulating emotional responses to social exclusion, and that depression is accompanied by social emotional dysregulation associated with reduced lateral prefrontal engagement. This study used anodal transcranial direct current stimulation (tDCS) to examine whether stimulating RVLPFC could improve emotional down-regulation of social exclusion in individuals with high depressive mood (DM).

Methods

A total of 96 high and 94 low DM individuals received active or sham tDCS while viewing social exclusion or individual negative pictures under no-reappraisal (passive viewing) and reappraisal conditions. Participants rate their negative emotional experience following the presentation of each image. Pupil diameter and visual fixation duration were also recorded during the task.

Results

It was found that tDCS-activated RVLPFC induced a stronger regulation effect on social exclusion than individual negative emotions. The effect of tDCS on regulation of social exclusion was more pronounced in low v. high DM individuals.

Conclusions

These findings demonstrate the specific role of RVLPFC on social emotion regulation, which has implications for refining target areas for the treatment of social emotion dysregulation in depression. However the findings do not suggest that high DM individuals benefit from a single-tDCS session on the emotion regulation of social exclusion. Thus we suggest to use multiple tDCS sessions or transcranial magnetic stimulation to further explore the therapeutic proposal in the future.

Keywords

Depression-pronedepressive moodemotion regulationeye trackingright ventrolateral prefrontal cortextranscranial direct current stimulation
Type
Original Articles
Information
Psychological Medicine , Volume 50 , Issue 16 , December 2020 , pp. 2768 - 2779
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Copyright
Copyright © Cambridge University Press 2019

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Footnotes

*

Both authors contributed equally to this study.

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