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Inflammation is correlated with abnormal functional connectivity in unmedicated bipolar depression: an independent component analysis study of resting-state fMRI

Published online by Cambridge University Press:  19 February 2021

Guixian Tang Open the ORCID record for Guixian Tang [Opens in a new window] ,
Pan Chen ,
Guanmao Chen ,
Shuming Zhong ,
JiaYing Gong ,
Hui Zhong ,
Tao Ye ,
Feng Chen ,
Jurong Wang  and
Zhenye Luo
...Show all authors
Guixian Tang
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Pan Chen
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Guanmao Chen
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Shuming Zhong
Affiliation:
Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China
JiaYing Gong
Affiliation:
Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China
Hui Zhong
Affiliation:
Biomedical Translational Research Institute, Jinan University, Guangzhou 510630, China
Tao Ye
Affiliation:
Clinical Laboratory Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Feng Chen
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Jurong Wang
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Zhenye Luo
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Zhangzhang Qi
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Yanbin Jia
Affiliation:
Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Ying Wang*
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Li Huang
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
*
Author for correspondence: Ying Wang, E-mail: johneil@vip.sina.com
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Abstract

Background

Inflammation might play a role in bipolar disorder (BD), but it remains unclear the relationship between inflammation and brain structural and functional abnormalities in patients with BD. In this study, we focused on the alterations of functional connectivity (FC), peripheral pro-inflammatory cytokines and their correlations to investigate the role of inflammation in FC in BD depression.

Methods

In this study, 42 unmedicated patients with BD II depression and 62 healthy controls (HCs) were enrolled. Resting-state-functional magnetic resonance imaging was performed in all participants and independent component analysis was used. Serum levels of Interleukin-6 (IL-6) and Interleukin-8 (IL-8) were measured in all participants. Correlation between FC values and IL-6 and IL-8 levels in BD was calculated.

Results

Compared with the HCs, BD II patients showed decreased FC in the left orbitofrontal cortex (OFC) implicating the limbic network and the right precentral gyrus implicating the somatomotor network. BD II showed increased IL-6 (p = 0.039), IL-8 (p = 0.002) levels. Moreover, abnormal FC in the right precentral gyrus were inversely correlated with the IL-8 (r = −0.458, p = 0.004) levels in BD II. No significant correlation was found between FC in the left OFC and cytokines levels.

Conclusions

Our findings that serum IL-8 levels are associated with impaired FC in the right precentral gyrus in BD II patients suggest that inflammation might play a crucial role in brain functional abnormalities in BD.

Keywords

Bipolar disorderfunctional connectivityfunctional magnetic resonance imaginginflammationinterleukin-8orbitofrontal cortexprecentral gyrus
Type
Original Article
Information
Psychological Medicine , Volume 52 , Issue 15 , November 2022 , pp. 3431 - 3441
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

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