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Magnetic resonance imaging volumetric measurements of the superior temporal gyrus, hippocampus, parahippocampal gyrus, frontal and temporal lobes in late paraphrenia

Published online by Cambridge University Press:  09 July 2009

R. Howard ,
J. Mellers ,
R. Petty ,
D. Bonner ,
R. Menon ,
O. Almeida ,
M. Graves ,
C. Renshaw  and
R. Levy
R. Howard*
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
J. Mellers
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
R. Petty
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
D. Bonner
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
R. Menon
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
O. Almeida
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
M. Graves
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
C. Renshaw
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
R. Levy
Affiliation:
Section of Old Age Psychiatry and Department of Neuropsychiatry, Institute of Psychiatry, the Maudsley Hospital and the Department of Radiological Sciences, Guy's Hospital, London
*
1 Address for correspondence: Dr Robert Howard, Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF.
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Synopsis

Quantified magnetic resonance measurements were made of superior temporal gyrus, parahippocampal gyrus, hippocampal, frontal and temporal lobe volumes and of the planar area of the thalamus and basal ganglia structures in 47 late paraphrenic patients and 33 healthy elderly controls. The late paraphrenics were divided into 31 schizophrenics and 16 patients with delusional disorder according to ICD-10 guidelines. Patients with delusional disorder tended to have smaller left temporal volumes compared with control subjects and patients with schizophrenia, but this difference failed to reach accepted levels of statistical significance after correction for the effects of multiple statistical comparisons, age and total brain size. Physiological right–left asymmetry, reported for temporal and frontal lobe volumes, was present in control, schizophrenic and delusional disorder subjects but delusional disorder patients had a significantly greater degree of temporal lobe asymmetry. The results add to the evidence for heterogeneity among late-onset psychoses and emphasize the subtle nature of any structural brain abnormalities in these patients.

Type
Original Articles
Information
Psychological Medicine , Volume 25 , Issue 3 , May 1995 , pp. 495 - 503
Copyright
Copyright © Cambridge University Press 1995

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References

Almeida, O. (1993). Clinical and cognitive diversity of psychotic stats arising in late life (late paraphrenia). Ph.D. thesis. University of London.Google Scholar
Almeida, O., Howard, R., Forstl, H. & Levy, R. (1992). Should the diagnosis of late paraphrenia be abandoned? Psychological Medicine 22, 11–14.Google Scholar
American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn. Revised (DSM-III R). APA: Washington, DC.Google Scholar
Barta, P. E., Pearlson, G. D., Powers, R. E., Richards, S. S. & Tune, L. E. (1990). Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. American Journal of Psychiatry 147, 1457–1462.Google ScholarPubMed
Bogerts, B., Meertz, E. & Schonfeldt-Bausch, R. (1985). Basal ganglia and limbic system pathology in schizophrenia: a morphometric study of brain volume and shrinkage. Archives of General Psychiatry 42, 784–791.CrossRefGoogle ScholarPubMed
Bogerts, B., Ashtari, M., Degreef, G., Alvir, J. M., Bilder, R. M. & Lieberman, J. A. (1990). Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Research 35, 1–13.Google Scholar
Breitner, J., Husain, M., Krishnan, K., Figiel, G. & Boyko, O. (1990). Cerebral white matter disease in late-onset paranoid psychosis. Biological Psychiatry 28, 266–274.CrossRefGoogle ScholarPubMed
Brown, R., Colter, N., Corsellis, J. A. N., Crow, T. J., Frith, C. D., Jagoe, R., Johnstone, E. C. & Marsh, L. (1986). Postmortem evidence of structural brain changes in schizophrenia. Archives of General Psychiatry 43, 36–42.CrossRefGoogle ScholarPubMed
Chui, H. D. & Damasio, A. R. (1980). Human cerebral asymetries evaluated by computerized tomography. Journal of Neurology, Neurosurgery and Psychiatry 43, 873–878.CrossRefGoogle Scholar
de Leon, M. J., Golomb, J., George, A. E., Convit, A., Tarshish, C. Y., McRae, T., De Santi, S., Smith, G., Ferris, S. H., Noz, M. & Rusinek, H. (1993). The radiologic prediction of Alzheimer's disease: the atrophic hippocampal formation. American Journal of Neuroradiology 14, 897–906.Google ScholarPubMed
DeLisi, L. E., Dauphinais, I. D. & Gershon, E. S. (1988). Perinatal complications and reduced size of brain limbic structures in familial schizophrenia. Schizophrenia Bulletin 14, 185–191.CrossRefGoogle ScholarPubMed
DeLisi, L. E., Hoff, A. L., Schwartz, J. E., Shields, G. W., Halthore, S. N., Gupta, S. M., Henn, F. A. & Anand, A. K. (1991). Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biological Psychiatry 29, 159–175.CrossRefGoogle ScholarPubMed
Duvernoy, H. M. (1988). The Human Hippocampus: An Atlas of Applied Anatomy, J. F. Bergmann: Munich.CrossRefGoogle Scholar
Flint, A. J., Rifat, S. L. & Eastwood, R. (1991). Late-onset paranoia: distinct from paraphrenia? International Journal of Geriatric Psychiatry 6, 103–109.Google Scholar
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12, 189–197.CrossRefGoogle Scholar
Galaburda, A. M., Sanides, F. & Geschwind, N. (1978). Human brain: cytoarchitectonic left-right asymmetries in the temporal speech region. Archives of Neurology 35, 812–817.CrossRefGoogle ScholarPubMed
Geschwind, N. & Levitsky, W. (1967). Human brain: left-right asymmetries in temporal speech region. Science 161, 186–187.CrossRefGoogle Scholar
Harvey, I., Ron, M. A., Du Boulay, G., Wicks, D., Lewis, S. W. & Murray, R. M. (1993). Reduction of cortical volume in schizophrenia on magnetic resonance imaging. Psychological Medicine 23, 591–604.Google Scholar
Howard, R., Forstl, H., Almeida, O., Burns, A. & Levy, R. (1992 a). Computer-assisted CT measurements in late paraphrenics with and without Schneiderian first rank symptoms: a preliminary report. International Journal of Geriatric Psychiatry 7, 35–38.CrossRefGoogle Scholar
Howard, R., Forstl, H., Naguib, M., Burns, A. & Levy, R. (1992 b). First rank symptoms of Schneider in late paraphrenia: cortical structural correlates. British Journal of Psychiatry 160, 108–109.Google Scholar
Howard, R., Almeida, O. & Levy, R. (1994 a). Phenomenology, demography and diagnosis in late paraphrenia. Psychological Medicine 24, 397–410.CrossRefGoogle ScholarPubMed
Howard, R., Almeida, O., Levy, R., Graves, P. & Graves, M. (1994 b).Quantitative magnetic resonance imaging volumetry of the brain, third and lateral ventricles in late paraphrenia distinguishes delusional disorder from late-onset schizophrenia. British Journal of Psychiatry 165, 474–480.Google Scholar
Jack, C. R., Gehring, D. G., Sharbrough, F. W., Felmlee, J. P., Forbes, G., Hench, V. S. & Zinmeister, A. R. (1988). Temporal lobe volume measurements from MR images: accuracy and left–right asymmetry in normal persons. Journal of Computer Assisted Tomography 12, 21–29.Google Scholar
Jack, C. R., Bentley, M. D., Twomey, C. K. & Zinsmeister, A. R. (1990). MR imaging-based volume measurements of the hippocampal formation and anterior temporal lobe: validation studies. Radiology 176, 205–209.Google Scholar
Jacoby, R., Levy, R. & Dawson, J. M. (1980). Computed tomography in the elderly. 1. The normal population. British Journal of Psychiatry 136, 249–255.Google Scholar
Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J. & Kreel, L. (1976). Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet ii, 924–926.CrossRefGoogle Scholar
Kelsoe, J. R., Cadet, J. L., Pickar, D. & Weinberger, D. R. (1988). Quantitative neuroanatomy in schizophrenia. Archives of General Psychiatry 45, 533–541.Google Scholar
LeMay, M. (1986). Left–right temporal region asymmetry in infants and children. American Journal of Neuroradiology 7, 974.Google Scholar
LeMay, M. & Kido, D. K. (1978). Asymmetries of cerebral hemispheres on computed tomograms. Journal of Computer Assisted Tomography 2, 471–476.Google Scholar
Luchins, D. J. & Meltzer, H. Y. (1983). A blind controlled study of occipital cerebral asymmetry in schizophrenia. Psychiatry Research 10, 87–95.CrossRefGoogle ScholarPubMed
Miller, B. L., Benson, F., Cummings, J. L. & Neshkes, R. (1986). Late-life paraphrenia: an organic delusional syndrome. Journal of Clinical Psychiatry 47, 204–207.Google Scholar
Miller, B. L., Lesser, I. M., Boone, K., Goldberg, M., Hill, E., Miller, M. H., Benson, D. F. & Mehringer, M. (1989). Brain white-matter lesions and psychosis. British Journal of Psychiatry 155, 73–78.Google Scholar
Miller, B. L., Lesser, I. M., Boone, K. B., Hill, E., Mehringer, C. M. & Wong, K. (1991). Brain lesions and cognitive function in late-life psychosis. British Journal of Psychiatry 158, 76–82.CrossRefGoogle ScholarPubMed
Naguib, M. & Levy, R. (1987). Late paraphrenia: neuropsychological impairment and structural brain abnormalities on computed tomography. International Journal of Geriatric Psychiatry 2, 83–90.CrossRefGoogle Scholar
Naidich, T. P., Daniels, D. L., Haughton, V. M., Williams, A., Pojunas, K. & Palacios, E. (1987). Hippocampal formation and related structures of the limbic lobe: anatomic-MR correlation. Part 1. Surface features and coronal sections. Radiology 162, 747–754.Google Scholar
Norušis, M. (1990). SPSS/PC + Statistics for the IBM PC/XT/AT and PS/2. SPSS International BV, PO Box 115, 4200 AC Gorinchem. Netherlands.Google Scholar
Pearlson, G. D., Tune, L. E., Powers, R. E., Wong, D. F., Rabins, P. V. & Barta, P. E. (1991). MRI and PET studies in late life onset schizophrenics. Schizophrenia Research 4, 409–410Google Scholar
Rabins, P., Pearlson, G., Jayaram, G., Steele, C. & Tune, L. (1987). Increased ventricle-to-brain ratio in late-onset schizophrenia. American Journal of Psychiatry 144, 1216–1218.Google ScholarPubMed
Robb, R. A., Hanson, D. P., Karwoski, R. A., Larson, E. G., Workman, E. L. & Stacy, M. C. (1989). ANALYZE: a comprehensive operator-interactive software package for multi-dimensional medical image display and analysis. Computerized Medical Imaging and Graphics 13, 433–454.CrossRefGoogle Scholar
Rossi, A., Stratta, P., D'Albenzio, L., Tartaro, A., Schiazza, G., Di Michele, V., Bolino, F. & Casacchia, M. (1990). Reduced temporal lobe areas in schizophrenia: preliminary evidence from a controlled multiplanar magnetic resonance imaging study. Biological Psychiatry 27, 61–68.Google Scholar
Shelton, R. C., Karson, C. N., Doran, A. R., Pickar, D., Bigelow, L. B. & Weinberger, D. R. (1988). Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal deficit. American Journal of Psychiatry 145, 154–163.Google Scholar
Shenton, M. E., Kikinsis, R., Jolesz, F. A., Pollak, S. D., LeMay, M., Wible, C. G., Hokama, H., Martin, J., Metcalf, D., Coleman, M. & McCarley, R. W. (1992). Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study. New England Journal of Medicine 327, 604–612.Google Scholar
Suddath, R. L., Casanova, M. F., Goldberg, T. E., Daniel, D. G., Kelsoe, J. R. & Weinberger, D. R. (1989). Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. American Journal of Psychiatry 146, 464–472.Google ScholarPubMed
Suddath, R. L., Christison, G. W., Torrey, E. F., Casanova, M. F. & Weinberger, D. R. (1990). Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine 322, 789–794.Google Scholar
Tsai, L. Y., Nasrallah, H. A. & Jacoby, C. G. (1983). Hemispheric asymmetries on computed tomographic scans in schizophrenia and mania: a controlled study and a critical review. Archives of General Psychiatry 40, 1286–1289.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979 a). Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry 36, 735–739.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979 b). Structural abnormalities in the cerebral cortex of chronic schizophrenic patients. Archives of General Psychiatry 36, 935–939.Google Scholar
Weinberger, D. R., Luchins, D. J., Morihisa, J. & Wyatt, R. J. (1982). Asymmetrical volumes of right and left frontal and occipital regions of the human brain. Annals of Neurology 11, 97–100.CrossRefGoogle ScholarPubMed
World Health Organization (1978). International Classification of Disease, 9th edn (ICD-9). WHO: Geneva.Google Scholar
World Health Organization (1992). The ICD-10 Classification of Mental and Behavioural Disorders. WHO: Geneva.Google Scholar
Young, A. H., Blackwood, D. H. R., Roxborough, H., McQueen, J. K., Martin, M. J. & Kean, D. (1991). A magnetic resonance imaging study of schizophrenia: brain structure and clinical symptoms. British Journal of Psychiatry 158, 158–164.Google Scholar