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Modification of the noradrenaline related effects of smoking by beta-blockade

Published online by Cambridge University Press:  09 July 2009

Malcolm Carruthers
Malcolm Carruthers
Affiliation:
Department of Chemical Pathology (Research), St Mary's Hospital Medical School, London
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Synopsis

Increases in plasma noradrenaline were found in a group of 12 subjects smoking cigarettes. The associated rises in pulse rate, blood pressure and plasma free fatty acids could be prevented by β-blockade with oxprenolol. This inhibition of the peripheral effects of catecholamines did not affect subjective satisfaction, indicating that central effects or other rewards are more important reinforcers. It is suggested that noradrenaline release in the hypothalamus is the final common pathway to pleasure in many situations, including smoking.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 2 , May 1976 , pp. 251 - 256
Copyright
Copyright © Cambridge University Press 1976

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References

REFERENCES

Åstrup, P. (1972). Some physiological and pathological effects of moderate carbon monoxide exposure. British Medical Journal iv, 447–452.CrossRefGoogle Scholar
Carruthers, M., Taggart, P., Salpeker, P. D. & Gatt, J. G. (1974). In Proceedings of CIBA-Geigy Symposium on Beta-blockers. Present status and future prospects. (In the Press.)Google Scholar
Carruthers, M., Taggart, P., Conway, N., Bates, D. & Somer-ville, W. (1970). Validity of plasma-catecholamine estimations. Lancet ii, 62–67.CrossRefGoogle Scholar
Carruthers, M. & Young, J. D. (1973). Free fatty acid estimation by a semi-automated fluorimetric method. Clinica chimica Acta 49, 341–348.CrossRefGoogle ScholarPubMed
Frankel, W. S. & Soloff, L. A. (1967). The hemodynamic effects of propranolol hydrochloride after smoking. American Journal of Medical Science 254, 623–628.CrossRefGoogle Scholar
Frankenhaeuser, M. (1971). In Levi, L. (ed.), Society, Stress and Disease. Oxford University Press: London.Google Scholar
Froberg, J., Karlsson, C., Levi, L. & Lidberg, L. (1971). In Levi, L. (ed.), Society, Stress and Disease. Oxford University Press: London.Google Scholar
Hall, G. H. & Turner, D. M. (1972). Effects of nicotine on the release of 3H-noradrenaline from the hypothalamus. Biochemical Pharmacology 21, 1829–1838.CrossRefGoogle Scholar
Heimstra, N. W., Bancroft, N. R. & DeKock, A. R. (1967). The effects of cigarette withdrawal on performance during simulated driving. Annals of the New York Academy of Sciences 142, 295–299.CrossRefGoogle Scholar
Hickey, R. J. & Harner, E. B. (1973). In Dunn, W. L. (ed.), Smoking Behaviour: Motives and Incentives. Winston: Washington.Google Scholar
Kershbaum, A., Bellet, S., Jiminez, J. & Feinberg, L. J. (1966). Differences in effects of cigar and cigarette smoking on free fatty acid mobilization and catecholamine secretion. Journal of the American Medical Association 195, 1095–1098.CrossRefGoogle Scholar
Kershbaum, A., Khrsandian, R., Caplan, R. F., Bellet, S. & Feinberg, L. J. (1963). The role of catecholamines in the free fatty acid response to cigarette smoking. Circulation 28, 52–57.CrossRefGoogle ScholarPubMed
Knapp, P. H., Bliss, C. M. & Wells, H. (1963). Withdrawal symptoms on stopping smoking. American Journal of Psychiatry 119, 966–971.CrossRefGoogle Scholar
Lancet, (1973). β-blockade for withdrawal symptoms. Lancet ii, 650.Google Scholar
Levi, L. (1967). The effect of coffee on the function of the sympathoadrena-medullary system in man. Acta Medica Scandinavica 181, 431–439.CrossRefGoogle ScholarPubMed
Lucchesi, B. R., Schuster, C. R. & Emley, G. S. (1967). The role of nicotine as a determinant of cigarette smoking frequency in man with observations of certain cardiovascular effects associated with the tobacco alkaloid. Clinical Pharmacology and Therapeutics 8, 789–796.CrossRefGoogle ScholarPubMed
Murchison, L. E. & Fyfe, T. (1966). Effects of cigarette smoking on serum-lipids, blood-glucose and platelet adhesiveness. Lancet i, 182–184.CrossRefGoogle Scholar
Pozner, H. & Billimoria, J. D. (1970). Effect of smoking on blood-clotting and lipid and lipoprotein levels. Lancet i, 1318–1321.CrossRefGoogle Scholar
Russell, M. A. H. (1974). Realistic goals for smoking and health: a case for safer smoking. Lancet i, 254–258.CrossRefGoogle Scholar
Russell, M. A. H., Cole, P. V. & Brown, E. (1973). Absorption by non-smokers of carbon monoxide from room air polluted by tobacco smoke. Lancet i, 576–579.CrossRefGoogle Scholar
Russell, M. A. H., Wilson, C., Patel, V. A., Feyerabend, C. & Cole, P. V. (1975). Plasma nicotine levels after smoking cigarettes with high, medium and low nicotine yields. British Medical Journal ii, 414–416.CrossRefGoogle Scholar
Schachter, S. (1973). Nesbitt's paradox. In Dunn, W. L. (ed.), Smoking Behaviour: Motives and Incentives. Winston: Washington, D.C.Google Scholar
Surgeon-General (1972). The Health Consequences of Smoking. U.S. Department of Health, Education and Welfare: Washington, D.C.Google Scholar
Taggart, P. & Carruthers, M. (1972). Suppression by oxprenolol of adrenergic response to stress. Lancet ii, 256–258.CrossRefGoogle Scholar
Taggart, P., Somerville, W. & Carruthers, M. (1973) Electrocardiogram, plasma catecholamines and lipids, and their modifications by oxprenolol when speaking before an audience. Lancet ii, 341–345.CrossRefGoogle Scholar
Turner, P., Granville-Grossman, K. L. & Smart, J. V. (1965). Effect of adrenergic receptor blockade on the tachycardia of thyrotoxicosis and anxiety state. Lancet ii, 1316–1319.CrossRefGoogle Scholar
Wise, C. D. & Stein, L. (1969). Facilitation of brain self-stimulation by central administration of norepinephrine. Science 163, 299–301.CrossRefGoogle ScholarPubMed