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A naturalistic, randomized, controlled trial combining cognitive remediation with cognitive–behavioural therapy after first-episode non-affective psychosis

Published online by Cambridge University Press:  30 October 2013

R. J. Drake ,
C. J. Day ,
R. Picucci ,
J. Warburton ,
W. Larkin ,
N. Husain ,
C. Reeder ,
T. Wykes  and
M. Marshall
R. J. Drake*
Affiliation:
University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Manchester Mental Health & Social Care NHS Trust, Manchester Academic Health Science Centre, Manchester, UK
C. J. Day
Affiliation:
Lancashire Care NHS Foundation Trust, Preston, UK
R. Picucci
Affiliation:
Lancashire Care NHS Foundation Trust, Preston, UK
J. Warburton
Affiliation:
Lancashire Care NHS Foundation Trust, Preston, UK
W. Larkin
Affiliation:
Lancashire Care NHS Foundation Trust, Preston, UK
N. Husain
Affiliation:
University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Lancashire Care NHS Foundation Trust, Preston, UK
C. Reeder
Affiliation:
Institute of Psychiatry, King's College London, London, UK Oxleas NHS Foundation Trust, Dartford, Kent, UK
T. Wykes
Affiliation:
Institute of Psychiatry, King's College London, London, UK
M. Marshall
Affiliation:
University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Lancashire Care NHS Foundation Trust, Preston, UK
*
*Address for correspondence: R. J. Drake, MRCPsych, PhD, Institute of Brain, Behaviour and Mental Health, University of Manchester, 3.315 Jean McFarlane Building, Oxford Road, Manchester M13 9PL, UK. (Email: richard.drake@manchester.ac.uk)
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Abstract

Background

Cognitive remediation (CR) preceding cognitive–behavioural therapy for psychosis (CBTp) was trialled within routine clinical services, with the hypothesis that following first-episode non-affective psychosis CR would enhance CBTp efficacy by improving neuropsychological performance.

Method

A total of 61 patients with DSM-IV non-affective psychoses waiting for routine CBTp were randomized to computerized CR over 12 weeks, supported by a trained support worker, or time-matched social contact (SC). Primary outcome was the blind-rated Psychotic Symptoms Rating Scale (PSYRATS). Secondary outcomes included measures of CBTp progress, cognition, symptoms, insight and self-esteem: all at baseline, after CR (12 weeks) and after CBTp (42 weeks). PSYRATS and global neuropsychological efficacy were tested using mixed-effects models with a group × time interaction term. Measures of CBTp progress and some neuropsychological measures were modelled by regression.

Results

There was no significant difference between the CR and SC groups in PSYRATS (group × time coefficient 0.3, 95% confidence interval −0.4 to 1.1, p = 0.39). However, after CR CBTp was shorter [median 7 sessions, interquartile range (IQR) 2–12 after CR; median 13, IQR 4–18 after SC; model p = 0.011] and linked to better insight (p = 0.02). Global cognition did not improve significantly more after CR (p = 0.20) but executive function did (Wisconsin Card Sort, p = 0.012).

Conclusions

CBTp courses preceded by CR were far shorter but achieved the same outcome as CBTp preceded by an active control, consistent with neuropsychological improvement enhancing CBTp. CR was delivered by staff with minimal training, offering the potential to reduce the costs of CBTp considerably.

Keywords

Cognitionearly interventionpsychological treatmentschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 9 , July 2014 , pp. 1889 - 1899
Copyright
Copyright © Cambridge University Press 2013 

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