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Parsing components of auditory predictive coding in schizophrenia using a roving standard mismatch negativity paradigm

Published online by Cambridge University Press:  15 January 2019

Amanda McCleery ,
Daniel H. Mathalon ,
Jonathan K. Wynn ,
Brian J. Roach ,
Gerhard S. Hellemann ,
Stephen R. Marder  and
Michael F. Green
Amanda McCleery*
Affiliation:
Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Daniel H. Mathalon
Affiliation:
Veterans Affairs San Francisco Healthcare System, San Francisco, CA, USA Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA
Jonathan K. Wynn
Affiliation:
Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Brian J. Roach
Affiliation:
Veterans Affairs San Francisco Healthcare System, San Francisco, CA, USA
Gerhard S. Hellemann
Affiliation:
Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Stephen R. Marder
Affiliation:
Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Michael F. Green
Affiliation:
Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
*
Author for correspondence: Amanda McCleery, E-mail: amccleery@mednet.ucla.edu
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Abstract

Background

Mismatch negativity (MMN) is an event-related potential (ERP) component reflecting auditory predictive coding. Repeated standard tones evoke increasing positivity (‘repetition positivity’; RP), reflecting strengthening of the standard's memory trace and the prediction it will recur. Likewise, deviant tones preceded by more standard repetitions evoke greater negativity (‘deviant negativity’; DN), reflecting stronger prediction error signaling. These memory trace effects are also evident in MMN difference wave. Here, we assess group differences and test-retest reliability of these indices in schizophrenia patients (SZ) and healthy controls (HC).

Methods

Electroencephalography was recorded twice, 2 weeks apart, from 43 SZ and 30 HC, during a roving standard paradigm. We examined ERPs to the third, eighth, and 33rd standards (RP), immediately subsequent deviants (DN), and the corresponding MMN. Memory trace effects were assessed by comparing amplitudes associated with the three standard repetition trains.

Results

Compared with controls, SZ showed reduced MMNs and DNs, but normal RPs. Both groups showed memory trace effects for RP, MMN, and DN, with a trend for attenuated DNs in SZ. Intraclass correlations obtained via this paradigm indicated good-to-moderate reliabilities for overall MMN, DN and RP, but moderate to poor reliabilities for components associated with short, intermediate, and long standard trains, and poor reliability of their memory trace effects.

Conclusion

MMN deficits in SZ reflected attenuated prediction error signaling (DN), with relatively intact predictive code formation (RP) and memory trace effects. This roving standard MMN paradigm requires additional development/validation to obtain suitable levels of reliability for use in clinical trials.

Keywords

deviant negativitymemory tracemismatch negativityprediction error signalingpredictive codingpsychotic disordersrepetition negativity
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 7 , May 2019 , pp. 1195 - 1206
Copyright
Copyright © Cambridge University Press 2019 

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Footnotes

*

Co-first authors.

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