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Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation

Published online by Cambridge University Press:  20 October 2010

L. Capuron ,
C. Poitou ,
D. Machaux-Tholliez ,
V. Frochot ,
J.-L. Bouillot ,
A. Basdevant ,
S. Layé  and
K. Clément
L. Capuron*
Affiliation:
Laboratory of Psychoneuroimmunology, Nutrition and Genetics (PSYNUGEN), University Victor Segalen Bordeaux 2, INRA 1286, CNRS 5226, 146 rue Léo Saignat, Bordeaux, F-33076 France
C. Poitou
Affiliation:
Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition and Endocrinology Department, CRNH-Ile de France, Paris, F-75013 France INSERM, U872, Nutriomique team 7, Paris, F-75006 France; Université Pierre et Marie Curie-Paris 6, Centre de Recherche des Cordeliers, UMR S 872, Paris, F-75006 France; Université Paris Descartes, UMR S 872, Paris, F-75006 France
D. Machaux-Tholliez
Affiliation:
Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition and Endocrinology Department, CRNH-Ile de France, Paris, F-75013 France
V. Frochot
Affiliation:
Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Endocrinology and Oncology Biochemistry Department, Paris, F-75013 France
J.-L. Bouillot
Affiliation:
Assistance Publique-Hôpitaux de Paris, Hotel-Dieu Hospital, Surgery Department, Paris, F-75013 France
A. Basdevant
Affiliation:
Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition and Endocrinology Department, CRNH-Ile de France, Paris, F-75013 France INSERM, U872, Nutriomique team 7, Paris, F-75006 France; Université Pierre et Marie Curie-Paris 6, Centre de Recherche des Cordeliers, UMR S 872, Paris, F-75006 France; Université Paris Descartes, UMR S 872, Paris, F-75006 France
S. Layé
Affiliation:
Laboratory of Psychoneuroimmunology, Nutrition and Genetics (PSYNUGEN), University Victor Segalen Bordeaux 2, INRA 1286, CNRS 5226, 146 rue Léo Saignat, Bordeaux, F-33076 France
K. Clément
Affiliation:
Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition and Endocrinology Department, CRNH-Ile de France, Paris, F-75013 France INSERM, U872, Nutriomique team 7, Paris, F-75006 France; Université Pierre et Marie Curie-Paris 6, Centre de Recherche des Cordeliers, UMR S 872, Paris, F-75006 France; Université Paris Descartes, UMR S 872, Paris, F-75006 France
*
*Address for correspondence: L. Capuron, Ph.D., Laboratory of Psychoneuroimmunology, Nutrition and Genetics (PSYNUGEN), University Victor Segalen Bordeaux 2, INRA 1286, CNRS 5226, 146 rue Léo Saignat, Bordeaux, F-33076 France. (Email: lucile.capuron@bordeaux.inra.fr)
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Abstract

Background

Obesity is characterized by chronic low-grade inflammation that may lead to emotional distress and behavioural symptoms. This study assessed the relationship between adiposity, low-grade inflammation, eating behaviour and emotional status in obese women awaiting gastric surgery and investigated the effects of surgery-induced weight loss on this relationship.

Method

A total of 101 women with severe or morbid obesity awaiting gastric surgery were recruited. Assessments were performed before and at 1 year post-surgery and included the measurement of neuroticism and extraversion using the revised Neuroticism–Extraversion–Openness personality inventory (NEO-PI-R) and eating behaviour using the Three-Factor Eating Questionnaire (TFEQ). Blood samples were collected for the measurement of serum inflammatory markers [interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP)] and adipokines (leptin, adiponectin).

Results

At baseline, body mass index (BMI) was positively correlated with inflammatory markers and adipokines. Regression analyses adjusting for age and diabetes revealed that baseline concentrations of IL-6 and hsCRP were associated with the depression and anxiety facets of neuroticism, with higher inflammation predicting higher anxiety and depression. This association remained significant after adjusting for BMI. Gastric surgery induced significant weight loss, which correlated with reduced inflammation. After controlling for BMI variations, decreases in inflammatory markers, notably hsCRP, were associated with reduced anxiety and TFEQ-cognitive restraint scores.

Conclusions

These findings indicate strong associations between adiposity, inflammation and affectivity in obese subjects and show that surgery-induced weight loss is associated concomitantly with reduced inflammation and adipokines and with significant improvement in emotional status and eating behaviour. Inflammatory status appears to represent an important mediator of emotional distress and psychological characteristics of obese individuals.

Keywords

Eating behaviourinflammationneuroticismobesitypsychological characteristicsweight loss
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 7 , July 2011 , pp. 1517 - 1528
Copyright
Copyright © Cambridge University Press 2010

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