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Respiration pattern variability and related default mode network connectivity are altered in remitted depression

Published online by Cambridge University Press:  16 January 2018

Vera Eva Zamoscik ,
Stephanie Nicole Lyn Schmidt ,
Martin Fungisai Gerchen ,
Christos Samsouris ,
Christina Timm ,
Christine Kuehner  and
Peter Kirsch
Vera Eva Zamoscik*
Affiliation:
Department of Clinical Psychology, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
Stephanie Nicole Lyn Schmidt
Affiliation:
Department of Clinical Psychology, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
Martin Fungisai Gerchen
Affiliation:
Department of Clinical Psychology, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Bernstein Center for Computational Neuroscience Heidelberg/Mannheim, Mannheim, Germany
Christos Samsouris
Affiliation:
Department of Clinical Psychology, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany University of Amsterdam, Amsterdam, The Netherlands
Christina Timm
Affiliation:
Research Group Longitudinal and Intervention Research, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
Christine Kuehner
Affiliation:
Research Group Longitudinal and Intervention Research, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
Peter Kirsch
Affiliation:
Department of Clinical Psychology, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Bernstein Center for Computational Neuroscience Heidelberg/Mannheim, Mannheim, Germany
*
Author for correspondence: Vera Eva Zamoscik, E-mail: vera.zamoscik@zi-mannheim.de
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Abstract

Background

Studies with healthy participants and patients with respiratory diseases suggest a relation between respiration and mood. The aim of the present analyses was to investigate whether emotionally challenged remitted depressed participants show higher respiration pattern variability (RPV) and whether this is related to mood, clinical outcome and increased default mode network connectivity.

Methods

To challenge participants, sad mood was induced with keywords of personal negative life events in individuals with remitted depression [recurrent major depressive disorder (rMDD), n = 30] and matched healthy controls (HCs, n = 30) during functional magnetic resonance imaging. Respiration was measured by means of a built-in respiration belt. Additionally, questionnaires, a daily life assessment of mood and a 3 years follow-up were applied. For replication, we analysed RPV in an independent sample of 53 rMDD who underwent the same fMRI paradigm.

Results

During sad mood, rMDD compared with HC showed greater RPV, with higher variability in pause duration and respiration frequency and lower expiration to inspiration ratio. Higher RPV was related to lower daily life mood and predicted higher depression scores as well as relapses during a 3-year follow-up period. Furthermore, in rMDD compared with HC higher main respiration frequency exhibited a more positive association with connectivity of the posterior cingulate cortex and the right parahippocampal gyrus.

Conclusions

The results suggest a relation between RPV, mood and depression on the behavioural and neural level. Based on our findings, we propose interventions focusing on respiration to be a promising additional tool in the treatment of depression.

Keywords

depressionparahippocampal gyrusrespiration pattern variabilityRPVvulnerability
Type
Original Articles
Information
Psychological Medicine , Volume 48 , Issue 14 , October 2018 , pp. 2364 - 2374
Copyright
Copyright © Cambridge University Press 2018 

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