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The role of oestrogen replacement in the climacteric syndrome

Published online by Cambridge University Press:  09 July 2009

Rudi Borth ,
Ronald C. Strickler ,
Anthony Cecutti ,
Brian A. Cookson ,
John A. Harper ,
Robert Potvin ,
Paul Riffel ,
V. James Sorbara  and
C. Allan Woolever
Rudi Borth*
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
Ronald C. Strickler
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
Anthony Cecutti
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
Brian A. Cookson
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
John A. Harper
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
Robert Potvin
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
Paul Riffel
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
V. James Sorbara
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
C. Allan Woolever
Affiliation:
From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada
*
1Address for correspondence: Dr Rudi Borth, Department of Obstetrics and Gynaecology, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.
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Synopsis

Using a double-blind placebo-controlled cross-over design, the effect of equine conjugated oestrogens tablets (Premarin®) was studied in 20 women with the climacteric syndrome followed during 15 months. Sixteen women were equally improved on placebo and oestrogen. Only 2 patients had an improved sense of well-being on oestrogen and not on placebo. The psychological diagnosis was unrelated to the subjective response to oestrogen or placebo. Performance in psychological tests administered before and during treatment periods was not changed by oestrogen or placebo.

Type
Research Article
Information
Psychological Medicine , Volume 7 , Issue 4 , November 1977 , pp. 631 - 639
Copyright
Copyright © Cambridge University Press 1977

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