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Rural environments reduce the genetic influence on adolescent substance use and rule-breaking behavior

Published online by Cambridge University Press:  01 October 2007

L. N. Legrand ,
M. Keyes ,
M. McGue ,
W. G. Iacono  and
R. F. Krueger
L. N. Legrand*
Affiliation:
Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN, USA
M. Keyes
Affiliation:
Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN, USA
M. McGue
Affiliation:
Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN, USA
W. G. Iacono
Affiliation:
Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN, USA
R. F. Krueger
Affiliation:
Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN, USA
*
*Address for correspondence: Dr L. N. Legrand, University of Minnesota, Department of Psychology, 75 East River Road, Minneapolis, MN 55455, USA. (Email: legra002@umn.edu)
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Abstract

Background

There is increasing evidence that certain environmental factors can modify genetic effects. This is an important area of investigation as such work will help to guide the development of new intervention programs. In this paper, we address whether rural environments moderate the genetic influence on adolescent substance use and rule-breaking behavior (i.e. externalizing psychopathology).

Method

Over 1200 Minnesotan 17-year-old twins were classified as either urban or rural. Externalizing behavior was operationalized as the use and abuse of alcohol and drugs along with symptoms of conduct, oppositional defiant, and antisocial personality disorders. Biometric factor modeling estimated whether the relative contribution of genetic and shared environmental factors varied from urban to rural settings.

Results

Residency effects reached statistical significance in the male sample only. In urban environments, externalizing behavior was substantially influenced by genetic factors, but in rural environments, shared environmental factors became more influential. This was apparent at both the individual-variable and factor levels.

Conclusions

These findings suggest a gene–environment interaction in the development of male adolescents' problem behaviors, including substance use. The results fit within an expanding literature demonstrating both the contextual nature of the heritability statistic and how certain environments may constrain the expression of genetic tendencies.

Keywords

Gene–environment interactionheritabilityruralurban
Type
Original Articles
Information
Psychological Medicine , Volume 38 , Issue 9 , September 2008 , pp. 1341 - 1350
Copyright
Copyright © 2007 Cambridge University Press

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