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Skin conductance responsivity during acute episodes of schizophrenia as a predictor of symptomatic improvement

Published online by Cambridge University Press:  09 July 2009

C. D. Frith ,
Marilyn Stevens ,
Eve C. Johnstone  and
T. J. Crow
C. D. Frith*
Affiliation:
CRC Division of Psychiatry, Harrow, Middlesex
Marilyn Stevens
Affiliation:
CRC Division of Psychiatry, Harrow, Middlesex
Eve C. Johnstone
Affiliation:
CRC Division of Psychiatry, Harrow, Middlesex
T. J. Crow
Affiliation:
CRC Division of Psychiatry, Harrow, Middlesex
*
1Address for correspondence: Dr C. D. Frith, CRC Division of Psychiatry, Watford Road, Harrow, Middlesex HAI 3UJ.
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Synopsis

Skin conductance responses to a series of tones were measured in 41 patients during an acute episode of schizophrenia before they received treatment and after 4 weeks of treatment with either α-flupenthixol, β-fiupenthixol or placebo. Patients who did not habituate to the tones prior to treatment tended to show no symptomatic improvement during the course of treatment. Patients who habituated and also showed an acute onset of their current symptoms (‘Feighner negative’ patients) showed a marked improvement even without active medication. Skin conductance responsivity did not change with improvement in symptoms alone, but decreased in patients on active medication (α-flupenthixol).

Non-habituation of skin conductance and insidious onset (i.e. fulfilment of the Feighner criteria) were found to be independent predictors of poor outcome. Taken together, these criteria may define a group of patients with particularly poor prognosis.

Type
Research Article
Information
Psychological Medicine , Volume 9 , Issue 1 , February 1979 , pp. 101 - 106
Copyright
Copyright © Cambridge University Press 1979

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References

Brockington, I. F. & Kendell, R. E. (1977). Criteria for a diagnosis of schizo-affective psychosis. Personal communication.Google Scholar
Bundy, R. S. & Fitzgerald, H. R. (1975). Stimulus specificity of electrodermal recovery time: an examination and reinterpretation of the evidence. Psychophysiology 12, 406–411.CrossRefGoogle ScholarPubMed
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry 26, 57–63.CrossRefGoogle ScholarPubMed
Fowler, R. C., McCabe, M., Cadoret, R. J. & Winokur, G. (1972). The validity of good prognosis schizophrenia. Archives of General Psychiatry 26, 182–185.CrossRefGoogle ScholarPubMed
Frith, C. D., Baker, H. F., Deakin, J. F. W., Johnstone, E. C. & Joseph, M. H. (1976). Brain noradrenaline metabolism and psychophysiological variables in chronic schizophrenia. Neuroscience Letters 3, 1–6.CrossRefGoogle Scholar
Gruzelier, J. H. (1976). Clinical attributes of schizophrenic skin conductance responders and non-responders. Psychological Medicine 6, 245–249.CrossRefGoogle ScholarPubMed
Gruzelier, J. H. & Venables, P. H. (1972). Skin conductance orienting activity in a heterogenous sample of schizophrenics. Possible evidence of limbic dysfunction. Journal of Nervous and Mental Disease 155, 277–287.CrossRefGoogle Scholar
Johnstone, E. C., Crow, T. J., Frith, C. D., Carney, M. W. P. & Price, J. S. (1978). The mechanism of the antipsychotic effect in the treatment of acute schizophrenia. Lancet i, 848–851.CrossRefGoogle Scholar
Krawiecka, M., Goldberg, D. & Vaughan, M. (1977). A standardized psychiatric assessment for rating chronic psychiatric patients. Acta Psychiatrica Scandinavica 55, 299–308.CrossRefGoogle Scholar
Lykken, D. T. & Venables, P. H. (1971). Direct measurement of skin conductance: a proposal for standardization. Psychophysiology 8, 656–672.CrossRefGoogle ScholarPubMed
Mednick, S. A. & Schulsinger, E. (1974). Nature-nurture aspects of schizophrenia. In Studies of Schizophrenia (ed. Lader, M. H.), pp. 36–41. Royal College of Psychiatrists: London.Google Scholar
Møller Nielsen, J., Pedersen, V., Nymark, M., Franck, K. F., Boeck, V., Fjalland, B. & Christensen, A. V. (1973). The comparative pharmacology of flupenthixol and some reference neuroleptics. Acta Pharmacologica et Toxicologica 33, 353–362.CrossRefGoogle Scholar
Winer, B. J. (1971). Statistical Principles in Experimental Design. McGraw-Hill: New York.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: London.Google Scholar