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Statistics and the nature of depression1

Published online by Cambridge University Press:  09 July 2009

G. Dunn ,
P. Sham  and
D. Hand
G. Dunn*
Affiliation:
Department of Biostatistics and Computing, Genetics Section, Institute of Psychiatry, London; Department of Statistics, The Open University, Milton Keynes
P. Sham
Affiliation:
Department of Biostatistics and Computing, Genetics Section, Institute of Psychiatry, London; Department of Statistics, The Open University, Milton Keynes
D. Hand
Affiliation:
Department of Biostatistics and Computing, Genetics Section, Institute of Psychiatry, London; Department of Statistics, The Open University, Milton Keynes
*
2Address for correspondence: Dr Graham Dunn, Department of Biostatistics and Computing, Institute of Psychiatry, De Crespigny Park, London SE5 8AF.
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Synopsis

A critical examination is made of the role that statistical methods have played in the understanding of depression. The development of instruments for measuring depression is illustrated by reference to the Beck Depression Inventory and the Hamilton Rating Scale. The controversy over the existence of one or two types of depression is examined from the perspective of the statistical tools used. Some of the problems in studies of the heritability of depression are outlined. The development of clinical trials of depression is examined, with particular reference to ECT and maintenance therapy, and the role of meta-analysis is discussed.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 4 , November 1993 , pp. 871 - 889
Copyright
Copyright © Cambridge University Press 1993

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Footnotes

1

Reproduced with the permission of the Royal Statistical Society from the Journal of the Royal Statistical Society, Series A (Statistics in Society) 156, 63–87 (1993).

References

Baron, M., Risch, N., Hamberger, R., Mandel, B., Kushner, S., Newman, M., Drumer, D. & Belmaker, R. H. (1987). Genetic linkage between X-chromosome markers and bipolar affective illnesses. Nature 326, 289–292.CrossRefGoogle Scholar
Bartholomew, D. J. (1987). Latent Variable Models and Factor Analyses. Griffin: London.Google Scholar
Batt, J. C. (1943). One hundred depressive psychoses treated with electrically induced convulsions. Journal of Mental Science 89, 289–296.CrossRefGoogle Scholar
Bech, P. (1981). Rating scales for affective disorders: their validity and consistency. Acta Psychiatrica Scandinavica Suppl. 295.Google Scholar
Beck, A. T. & Beamesderfer, A. (1974). Assessment of depression: the depression inventory. In Psychological Measurements in Psychopharmacology. Modern Problems in Pharmacopsychiatry, 7 (ed Pichot, P.). pp. 151–169. Karger: Basel.Google Scholar
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J. E. & Erbaugh, J. K. (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561–571.CrossRefGoogle ScholarPubMed
Becker, J. (1974). Depression: Theory and Research. V. H. Winston: Washington, D.C.Google Scholar
Bertelsen, A., Harvald, B. & Hauge, M. (1977). A Danish twin study of manic-depressive disorders. British Journal of Psychiatry 130, 330–351.CrossRefGoogle ScholarPubMed
Birnbaum, A. (1968). Some latent trait models and their use in inferring an examinee's ability. In Statistical Theory of Mental Test Scores (ed. Lord, F. M. and Novick, M. R.), pp. 397–479. Addison-Wesley: Reading, Mass.Google Scholar
Boyle, G. J. (1985). Self-report measures of depression: some psychometric considerations. British Journal of Clinical Psychology 24, 45–59.CrossRefGoogle ScholarPubMed
Brown, G. W. & Harris, T. (1978). The Social Origins of Depression. Tavistock: London.Google ScholarPubMed
Brown, W. (1910). Some experimental results in the correlation of mental abilities. British Journal of Psychology 3, 296–322.Google Scholar
Brown, W. (1911). The Essentials of Mental Measurement. Cambridge University Press: Cambridge.Google Scholar
Bucher, K. & Elston, C. (1981). The transmission of manic depressive illness. I. Theory, description of the model and summary of results. Journal of Psychiatric Research 16, 53–63.CrossRefGoogle ScholarPubMed
Burt, C. (1940). The Factors of the Mind. University of London Press: London.Google Scholar
Burt, C. (1952). Dr. William Brown. British Journal of Psychology, Statistical Section 5, 137–138.Google Scholar
Carney, M. W. P., Roth, M. & Garside, R. F. (1965). The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry 111, 659–674.CrossRefGoogle Scholar
Conte, H. R., Plutchik, K., Wild, K. V. & Karasu, T. B. (1984). Combined psychotherapy and pharmacotherapy for depression. Archives of General Psychiatry 43, 471–479.CrossRefGoogle Scholar
Cox, N., Reich, J., Rice, J., Elston, R., Schlober, J. & Keats, B. (1989). Segregation and linkage analyses of bipolar and major depressive illnesses in multigenerational pedigrees. Journal of Psychiatric Research 23, 109–123.CrossRefGoogle ScholarPubMed
Crow, T. J. (1979). The scientific status of electro-convulsive therapy. Psychological Medicine 9, 401–408.CrossRefGoogle ScholarPubMed
Davies, D. L. & Shepherd, M. (1955). Reserpine in the treatment of anxious and depressed patients. Lancet 269, 117–120.CrossRefGoogle ScholarPubMed
Detera-Wadleigh, S. D.Berrettini, W. H., Goldin, L. R., Boorman, D., Anderson, S. & Gershon, E. S. (1987). Close linkage of c-Harvey-ras-1 and insulin gene to affective disorder is ruled out in three North American pedigrees. Nature 325, 806–808.CrossRefGoogle ScholarPubMed
Edward, B. C., Lambert, M. J., Moran, P. W., McNally, T., Smith, T. C. & Ellingson, A. G. (1984). A meta-analytic comparison of the Beck Depression Inventory and the Hamilton Rating Scale for depression as measures of treatment outcome. British Journal of Clinical Psychology 23, 93–99.CrossRefGoogle Scholar
Edwards, J. H. & Watt, D. C. (1989). Caution in locating the gene(s) for affective disorder. Psychological Medicine 19, 273–275.CrossRefGoogle ScholarPubMed
Egeland, J. A., Gerhard, D. S., Pauls, D. L., Sussex, J. N., Kidd, K. K., Allen, C. R., Hostetter, A. M. & Housman, D. E. (1987). Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325, 737–787.CrossRefGoogle ScholarPubMed
Ellund, H. B. & Doering, C. R. (1928). The application of statistical method to the study of mental disease. American Journal of Psychiatry 84, 789–808.Google Scholar
Everitt, B. S. (1981). Bimodality and the nature of depression. British Journal of Psychiatry 138, 336–339.CrossRefGoogle ScholarPubMed
Everitt, B. S. (1987). Statistics in psychiatry. Statistical Science 2, 107–134.CrossRefGoogle Scholar
Everitt, B. S., Gourlay, A. J. & Kendell, R. E. (1971). An attempt at validation of traditional psychiatric syndromes by cluster analysis. British Journal of Psychiatry 119, 399–412.CrossRefGoogle ScholarPubMed
Everitt, B. S. & Smith, A. M. R. (1979). Interactions in contingency tables: a brief discussion of alternative definitions. Psychological Medicine 9, 581–583.CrossRefGoogle ScholarPubMed
Eysenck, H. J. (1970). The classification of depressive illness. British Journal of Psychiatry 117, 241–250.CrossRefGoogle Scholar
Fisher, R. A. (1942). The Design of Experiments (3rd edn). Oliver and Boyd: Edinburgh.Google Scholar
Fitzgerald, O. W. S. (1943). Experiences in the treatment of depressive states by electrically induced convulsions. Journal of Mental Science 89, 73–80.CrossRefGoogle Scholar
Fleiss, J. L. (1972). Classification of depressive disorders by numerical typology. Journal of Psychiatric Research 9, 141–153.CrossRefGoogle ScholarPubMed
Galton, F. (1875). The history of twins, as a criterion of the relative powers of nature and nurture. Popular Science Monthly 8, 345–357.Google Scholar
Gershon, E. S., Baron, M. & Leckman, J. F. (1975). Genetic models of the transmission of affective disorders. Journal of Psychiatric Research 12, 301–317.CrossRefGoogle Scholar
Gershon, E. S., Targum, S. D., Leckman, J. F., Guroff, J. J. & Murphy, D. L. (1979). Platelet monoamine oxidase (MAO) activity and genetic vulnerability to bipolar (BP) affective illness. Psychopharmacological Bulletin 15, 27–30.Google ScholarPubMed
Gilbert, P. (1984). Depression: from Psychology to Brain State. Lawrence Erlbaum: London.Google Scholar
Glen, A. I. M., Johnson, A. L. & Shepherd, M. (1984). Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial. Psychological Medicine 14, 37–50.CrossRefGoogle ScholarPubMed
Grayson, D. A. (1987). Can categorical and dimensional views of psychiatric illness be distinguished? British Journal of Psychiatry 151, 355–361.CrossRefGoogle ScholarPubMed
Greenblatt, M., Grosser, G. H. & Wechsler, H. (1964). Differential response of hospitalized patients to somatic therapy. American Journal of Psychiatry 120, 935–943.CrossRefGoogle ScholarPubMed
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry 23, 56–61.CrossRefGoogle ScholarPubMed
Hamilton, M. (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278–296.CrossRefGoogle ScholarPubMed
Hamilton, M. & White, J. M. (1959). Clinical syndromes in depressive states. Journal of Mental Science 105, 985–998.CrossRefGoogle ScholarPubMed
Hand, D. J. (1985). The role of statistics in psychiatry. Psychological Medicine 15, 471–476.CrossRefGoogle ScholarPubMed
Hart, B. & Spearman, C. (1912). General ability, its existence and nature. British Journal of Psychology 9, 51–84.Google Scholar
Hedlund, J. L. and Vieweg, B. W. (1979). The Hamilton Rating Scale for Depression: a comprehensive review. Journal of Operational Psychology 10, 149–165.Google Scholar
Heron, D. (1914). An examination of some recent studies of the inheritance factor in insanity. Biometrika 10, 356–383.CrossRefGoogle Scholar
Hill, A. B. (1962). Statistical Methods in Clinical and Preventative Medicine. Livingstone: Edinburgh.Google Scholar
Hogkinson, S., Sherrington, R., Gurling, H., Marchbanks, R., Reeders, S., Mallet, J., McInnes, M., Petursson, H. & Brynjolfsson, J. (1987). Molecular genetic evidence for heterogeneity in manic depression. Nature 325, 805–806.CrossRefGoogle Scholar
Jasper, H. H. (1930). The measurement of depression–elation and its relation to a measure of extraversion–introversion. Journal of Abnormal and Social Psychology 25, 307–318.CrossRefGoogle Scholar
Jenick, M. (1989). Meta-analysis in medicine. Where we are and where we want to go. Journal of Clinical Epidemiology 42, 35–44.CrossRefGoogle Scholar
Johnson, A. L. (1983). Clinical trials in psychiatry. Psychological Medicine 13, 1–8.CrossRefGoogle ScholarPubMed
Johnson, A. L. (1989). Methodology in clinical trials in psychiatry. In Research Methods in Psychiatry: A Beginner's Guide (ed. Freeman, C. and Tyrer, P.), pp. 12–45. Royal College of Psychiatrists: London.Google Scholar
Johnstone, E. C., Deakin, J. F. W., Lawler, P., Frith, C. D., Stevens, M., McPherson, K. & Crow, T. J. (1980). The Northwick Park Electroconvulsive Therapy Trial. Lancet ii, 1317–1320.CrossRefGoogle Scholar
Karagulla, S. (1950). Evaluation of electric convulsion therapy as compared with conservative methods of treatments of depressive states. Journal of Mental Science 96, 1060–1091.CrossRefGoogle ScholarPubMed
Kear-Colwell, J. J. (1972). A taxonomy of depressive phenomena and its relationship to the reactive–endogenous dichotomy. British Journal of Psychiatry 121, 655–671.CrossRefGoogle Scholar
Kelley, T. L. (1923). Statistical Method. Macmillan: New York.Google Scholar
Kelsoe, J. R., Ginns, A. I., Egeland, J. A., Gerhard, D. S., Goldstein, A. M., Bale, S. J., Pauls, D. L., Long, R. T., Kidd, K. K., Conte, G., Housman, D. K. & Paul, S. M. (1989). Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342, 238–243.CrossRefGoogle ScholarPubMed
Kendell, R. E. (1968). The Classification of Depressive Illnesses. Oxford University Press: Oxford.Google Scholar
Kendell, R. E. (1976). The classification of depression: a review of contemporary confusion. British Journal of Psychiatry 129, 15–28.CrossRefGoogle ScholarPubMed
Kidd, K. K. & Ott, J. (1984). Power and sample size in linkage studies. Human Gene Mapping 7, 510–511.Google Scholar
Kiloh, L. G. & Garside, R. F. (1963). The independence of neurotic depression and endogenous depression. British Journal of Psychiatry 109, 451–463.CrossRefGoogle ScholarPubMed
Kiloh, L. G., Gavin, A., Neilson, M. & Bianchi, G. N. (1972). The relationship of the syndromes called endogenous and neurotic depression. British Journal of Psychiatry 121, 183–196.CrossRefGoogle ScholarPubMed
Leckman, J. F., Gershon, E. S., McGuiness, M. H., Targum, S. D. & Dibble, E. (1979). New data do not suggest linkage between Xg blood group and bipolar illness. Archives of General Psychiatry 36, 1435–1441.CrossRefGoogle Scholar
Lewis, A. J. (1931). Genetic problems in psychiatry and their solution by the study of twins. Eugenics Review 23, 119–125.Google Scholar
Lewis, A. J. (1934). Inheritance of mental disorders. In The Chances of Morbid Inheritance (ed. Blacker, C. P.), pp. 86–133. Lewis: London.Google Scholar
Lewis, A. J. (1946). On the place of physical treatment in psychiatry. British Medical Bulletin 3, 22–24.Google Scholar
Loranger, A. W., Prout, C. T. & White, A. A. (1961). The placebo effect in psychiatric drug research. Journal of the American Medical Association 176, 920–925.CrossRefGoogle ScholarPubMed
Luxenberger, H. (1928). Vorlaufiger Bericht über psychiatrische Serienuntersuchungen von Zwillingen. Zeitschrift für die Gesamte Neurologie und Psychiatrie 116, 296–326.Google Scholar
McConaghy, N., Joffe, A. D. & Murphy, B. (1967). The independence of neurotic and endogenous depression. British Journal of Psychiatry 113, 479–484.CrossRefGoogle ScholarPubMed
McGuffin, P. & Katz, R. (1986). Nature, nurture and affective disorder. In The Biology of Affective Disorders (ed. Deakin, J. F. W.), pp. 26–52. Royal College of Psychiatrists/Gaskell Press: London.Google Scholar
MacQueen, J. (1967). Some methods of classification and analysis of multivariate observations. Proceedings of the 5th Berkeley Symposium on Mathematical Statistics and Probability, pp. 281–297. University of California Press: Berkeley, Cal.Google Scholar
Mapother, E. (1928). Review of The Abilities of Man by C. Spearman. Journal of Mental Science 74, 113–119.CrossRefGoogle Scholar
Mayer, J. M. (1978). Assessment of depression. In Advances in Psychological Assessment (ed. McReynolds, P.), vol. 4, pp. 358–425. Jossey-Bass: Washington, D.C.Google Scholar
Maxwell, A. E. (1972). Difficulties in the dimensional description of symptomatology. British Journal of Psychiatry 121, 19–26.CrossRefGoogle ScholarPubMed
Medical Research Council (1965). Clinical trial of the treatment of depressive illness. British Medical Journal i, 881–886.Google Scholar
Medical Research Council (1981). Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a controlled clinical trial. Psychological Medicine 11, 409–416.CrossRefGoogle Scholar
Mendlewicz, J., Simon, P., Sevy, S., Charon, F., Brocas, H., Legros, S. & Vassart, G. (1987). Polymorphic DNA marker on X chromosome and manic depression. Lancet i, 1230–1232.CrossRefGoogle Scholar
Miller, D. H., Clancy, J. & Cumming, E. (1953). A comparison between unidirectional current nonconvulsive electrical stimulation given with Reiter's machine, standard alternating current electroshock (Cerletti method) and pentothal in chronic schizophrenia. American Journal of Psychiatry 189, 226–240.Google Scholar
Mindham, R. H. S., Howland, C. & Shepherd, M. (1973). An evaluation of continuation therapy with tricyclic antidepressants in depressive illness. Psychological Medicine 3, 5–17.CrossRefGoogle ScholarPubMed
Moran, P. A. P. (1966). The establishment of a psychiatric syndrome. British Journal of Psychiatry 112, 1165–1171.CrossRefGoogle ScholarPubMed
Morton, N. E. (1955). Sequential tests for the detection of linkage. American Journal of Human Genetics 7, 277–318.Google ScholarPubMed
Mowbray, R. M. (1972). The Hamilton Rating Scale for depression: a factor analysis. Psychological Medicine 2, 272–280.CrossRefGoogle ScholarPubMed
Murphy, E. A. (1964). One cause? Many causes? The argument from the bimodal distribution. Journal of Chronic Diseases 17, 301–324.CrossRefGoogle ScholarPubMed
Napier, F. J. (1944). Death from electric convulsion therapy. Journal of Mental Science 90, 875–878.CrossRefGoogle Scholar
Ott, J. (1986). Linkage probability and its approximate confidence interval under possible heterogeneity. Genetic Epidemiology, suppl. no. 1, 251–257.CrossRefGoogle Scholar
Overall, J. E., Hollister, C. E., Johnson, M. & Pennington, J. (1966). Nosology of depression and differential response to drugs. Journal of the American Medical Association 195, 946–948.CrossRefGoogle ScholarPubMed
Paykel, E. S. (1971). Classification of depressed patients: a cluster-analysis-derived grouping. British Journal of Psychiatry 118, 275–288.CrossRefGoogle ScholarPubMed
Paykel, E. S. (1981). Have multivariate statistics contributed to classification? British Journal of Psychiatry 139, 357–362.CrossRefGoogle ScholarPubMed
Paykel, E. S. (ed.) (1982). Handbook of Affective Disorders. Churchill Livingstone: Edinburgh.Google Scholar
Paykel, E. S., Demascio, A., Haskell, D. & Prusoff, B. A. (1975). Effects of maintenance amitriptyline and psychotherapy on symptoms of depression. Psychological Medicine 5, 67–77.CrossRefGoogle ScholarPubMed
Pickles, A. (1991). The analysis of change in longitudinal studies of development. Journal of Child Psychology and Psychiatry 32, 571–579.CrossRefGoogle ScholarPubMed
Pilowsky, I., Levine, S. & Boulton, D. M. (1969). The classification of depression by numerical taxonomy. British Journal of Psychiatry 115, 937–945.CrossRefGoogle ScholarPubMed
Pocock, S. J., Hughes, M. D. & Lee, R. J. (1987). Statistical problems in the reporting of clinical trials. New England Journal of Medicine 317, 426–432.CrossRefGoogle ScholarPubMed
Quality Assurance Project (1983). A treatment outline for depressive disorder. Australian and New Zealand Journal of Psychiatry 17, 129–146.CrossRefGoogle Scholar
Rasch, G. (1960). Probabilistic Models for Some Intelligence and Attainment Tests. Danish Institute for Educational Research: Copenhagen. (Reprinted by University of Chicago Press, Chicago, 1980.)Google Scholar
Reich, T., Van Eerdewegh, P., Rice, J., Mullaney, J., Endicott, J. & Klerman, G. L. (1987). The familial transmission of primary major depressive disorder. Journal of Psychiatric Research 21, 613–624.CrossRefGoogle ScholarPubMed
Rice, J., Reich, T., Andreasen, N., Endicott, J., Van Eerdewegh, M., Fishman, R., Herschfeld, R. M. A. & Klerman, G. L. (1987). The familial transmission of bipolar illness. Archives of General Psychiatry 44, 441–447.Google Scholar
Risch, N. (1991). A note on multiple testing procedures in linkage analysis. American Journal of Human Genetics 48, 1058–1064.Google Scholar
Robertson, M. (1987). Molecular genetics of the mind. Nature 325, 755.CrossRefGoogle ScholarPubMed
Robertson, M. (1989). False start on manic depression. Nature 342, 222.CrossRefGoogle ScholarPubMed
Rümke, H. C. (1960). Psychiatrie, vol. 2. Scheltema en Holkema: Amsterdam.Google Scholar
Sandifer, M. G., Wilson, I. C. & Green, L. (1966). The two-type thesis of depressive disorders. American Journal of Psychiatry 123, 93–97.Google Scholar
Sargant, W. (1965). Antidepressant drugs. British Medical Journal i, 1495.CrossRefGoogle Scholar
Sargant, W. & Slater, E. (1944). An Introduction to Physical Methods of Treatment in Psychiatry. Livingstone: Edinburgh.Google Scholar
Sargant, W. & Slater, E. (1963). An Introduction to Physical Methods of Treatment in Psychiatry, 4th edn.Livingstone: Edinburgh.Google Scholar
Shepherd, M. (1959). Evaluation of drugs in the treatment of depression. Canadian Psychiatric Association Journal 4, Suppl, S120–S128.CrossRefGoogle Scholar
Shepherd, M. (1963). Evaluation of treatment in psychiatry. In Methods of Psychiatric Research (ed. Sainsbury, P. and Kreitman, N.), pp. 49–58. Oxford University Press: London.Google Scholar
Shepherd, M. (1969). Some aspects of clinical trials in psychiatry. In Practical Treatment in Psychiatry (ed. Crammer, J. L.), pp. 145–157. Blackwell: Oxford.Google Scholar
Shepherd, M. (1970). Evaluation of psychotropic drugs. 2. Depression. In Principles and Practice of Clinical Trials (ed. Harris, E. L. and Fitzgerald, J. P.), pp. 199–216. Livingstone: Edinburgh.Google Scholar
Shepherd, M., Goodman, N. & Watt, D. C. (1961). The application of hospital statistics in evaluation of pharmacology in a psychiatric population. Comprehensive Psychiatry 2, 11–19.CrossRefGoogle Scholar
Simins, C. (1933). Studies in experimental psychiatry. IV. Deterioration of ‘G’ in psychotic patients. Journal of Mental Science 79, 704–734.CrossRefGoogle Scholar
Slater, E. (1935). The incidence of mental disorder. Annuals of Eugenics 6, 172–186.CrossRefGoogle Scholar
Slater, E. (1936). The inheritance of manic-depressive insanity. Proceedings of the Royal Society of Medicine 29, 981–990.CrossRefGoogle ScholarPubMed
Slater, E. (1938 a). Zur Erbathologie des manisch-depressiven Irreseins. Die Eltern und Kinder. Zeitschrift für die Gesamte Neurologie und Psychiatrie 163, 1–47.CrossRefGoogle Scholar
Slater, E. (1938 b). Zur Periodik des manisch-depressiven Irreseins. Zeitschrift für Gesamte Neurologie und Psychiatrie 162, 794–801.CrossRefGoogle Scholar
Slater, E. (1951). Evaluation of electric convulsion therapy as compared with conservative methods of treatment in depressive states. Journal of Mental Science 97, 567–569.CrossRefGoogle ScholarPubMed
Slater, E. (1953). Psychotic and Neurotic Illnesses in Twins. MRC Special Report Series No. 278. HMSO: London.Google ScholarPubMed
Slater, E. (1963). Diagnosis of zygosity by fingerprints. Acta Psychiatrica Scandinavica 39, 78–84.Google Scholar
Slater, E. (1971). Autobiographical sketch. In Man, Mind, and Heredity (ed. Shields, G. and Gottesman, I. I.), pp. 1–23. Johns Hopkins University Press: Baltimore, Md.Google Scholar
Slater, P., Shields, J. & Slater, E. (1964). A quadratic discriminant of zygosity from fingerprints. Journal of Medical Genetics 1, 42–46.CrossRefGoogle ScholarPubMed
Smith, A., Traganza, E. & Harrison, G. (1969). Studies on the effectiveness of antidepressant drugs. Psychopharmacology Bulletin (March), pp. 1–53.Google Scholar
Spearman, C. (1904). General intelligence, objectively determined and measured. American Journal of Psychology 19, 201–293.CrossRefGoogle Scholar
Spearman, C. (1910). Correlation calculated from faulty data. British Journal of Psychology 3, 271–295.Google Scholar
Spearman, C. (1927). The Abilities of Man. Macmillan: New York.Google Scholar
Spearman, C. (1929). The Tenth Maudsley Lecture: The psychiatric use of the methods and results of experimental psychology. Journal of Mental Science 75, 357–370.CrossRefGoogle Scholar
Spence, M. A. (1987). Genetic linkage: sampling issues and multipoint mapping. Journal of Psychiatric Research 21, 631–637.CrossRefGoogle ScholarPubMed
Stephenson, W. (1931). Studies in experimental psychiatry. I. A case of general inertia. Journal of Mental Science 77, 723–741.CrossRefGoogle Scholar
Stephenson, W. (1932 a). Studies in experimental psychiatry. II. Some contact of p-factor with psychiatry. Journal of Mental Science 78, 315–330.CrossRefGoogle Scholar
Stephenson, W. (1932 b). Studies in experimental psychiatry. III. p-score and inhibition for high-p praecox cases. Journal of Mental Science 78, 908–928.Google Scholar
Studman, L. G. (1935). Studies in experimental psychiatry. V. ‘W’ and ‘F’ factors in relation to traits of personality. Journal of Mental Science 81, 107–137.CrossRefGoogle Scholar
Tennant, C. & Bebbington, P. (1978). The social origins of depression: a critique of the work of Brown and his colleagues. Psychological Medicine 8, 565–575.CrossRefGoogle Scholar
Thompson, E. A. (1984). The interpretation of LOD scores with a set of marker loci. Genetic Epidemiology 1, 357–362.CrossRefGoogle ScholarPubMed
Wallace, C. S. & Boulton, D. M. (1968). An information measure for classification. Computer Journal 11, 185–194.Google Scholar
Wechsler, H., Grosser, G. H. & Greenblatt, M. (1969). Research evaluating antidepressant medications on hospitalized mental patients: a survey of published reports during a five-year period. Journal of Mental and Nervous Disease 141, 231–239.Google Scholar
Weckowicz, T. E., Muir, W. & Cropley, A. (1978). A factor analysis of the Beck inventory of depression. Journal of Consulting Psychology 87, 155–164.Google Scholar
Winokur, G. & Tanna, V. L. (1969). Possible role of X-linked dominant factor in manic depressive illness. Diseases of the Nervous System 30, 89–94.Google Scholar
Wynn Jones, L. L. (1928). An investigation into the significance of perseveration. Journal of Mental Science 74, 653–659.CrossRefGoogle Scholar
Yule, G. U. (1911). Introduction to the Theory of Statistics. Griffin: London.CrossRefGoogle Scholar