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Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology

Published online by Cambridge University Press:  08 April 2015

N. S. Corral-Frías ,
Y. S. Nikolova ,
L.J. Michalski ,
D. A. A. Baranger ,
A. R. Hariri  and
R. Bogdan
N. S. Corral-Frías*
Affiliation:
Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
Y. S. Nikolova
Affiliation:
Laboratory of NeuroGenetics, Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
L.J. Michalski
Affiliation:
BRAIN Laboratory, Department of Psychology, Washington University in St Louis, St Louis, MO, USA
D. A. A. Baranger
Affiliation:
BRAIN Laboratory, Department of Psychology, Washington University in St Louis, St Louis, MO, USA Division of Biology and Biomedical Sciences, Washington University in St Louis, St Louis, MO, USA
A. R. Hariri
Affiliation:
Laboratory of NeuroGenetics, Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
R. Bogdan
Affiliation:
Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA BRAIN Laboratory, Department of Psychology, Washington University in St Louis, St Louis, MO, USA Division of Biology and Biomedical Sciences, Washington University in St Louis, St Louis, MO, USA
*
*Address for correspondence: N. S. Corral-Frías, Ph.D., BRAIN Laboratory, Campus Box 1125, Psychology Bldg, Washington University in St Louis, One Brookings Dr., St Louis, MO 63130, USA. (Email: corraln@psychiatry.wustl.edu)
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Abstract

Background

Early life stress (ELS) is consistently associated with increased risk for subsequent psychopathology. Individual differences in neural response to reward may confer vulnerability to stress-related psychopathology. Using data from the ongoing Duke Neurogenetics Study, the present study examined whether reward-related ventral striatum (VS) reactivity moderates the relationship between retrospectively reported ELS and anhedonic symptomatology. We further assessed whether individual differences in reward-related VS reactivity were associated with other depressive symptoms and problematic alcohol use via stress-related anhedonic symptoms and substance use-associated coping.

Method

Blood oxygen level-dependent functional magnetic resonance imaging (fMRI) was collected while participants (n = 906) completed a card-guessing task, which robustly elicits VS reactivity. ELS, anhedonic symptoms, other depressive symptoms, coping behavior, and alcohol use behavior were assessed with self-report questionnaires. Linear regressions were run to examine whether VS reactivity moderated the relationship between ELS and anhedonic symptoms. Structural equation models examined whether this moderation was indirectly associated with other depression symptoms and problematic alcohol use through its association with anhedonia.

Results

Analyses of data from 820 participants passing quality control procedures revealed that the VS × ELS interaction was associated with anhedonic symptoms (p = 0.011). Moreover, structural equation models indirectly linked this interaction to non-anhedonic depression symptoms and problematic alcohol use through anhedonic symptoms and substance-related coping.

Conclusions

These findings suggest that reduced VS reactivity to reward is associated with increased risk for anhedonia in individuals exposed to ELS. Such stress-related anhedonia is further associated with other depressive symptoms and problematic alcohol use through substance-related coping.

Keywords

Alcoholanhedoniadepressionearly life stressfMRIrewardventral striatum
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 12 , September 2015 , pp. 2605 - 2617
Copyright
Copyright © Cambridge University Press 2015 

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