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Symptom dimensions and cognitive and social functioning in recent-onset schizophrenia

Published online by Cambridge University Press:  09 July 2009

A. J. W. Van Der Does ,
P. M. A. J. Dingemans ,
D. H. Linszen ,
M. A. Nugter  and
W. F. Scholte
A. J. W. Van Der Does*
Affiliation:
Department of Psychiatry, Leiden University; Department of Psychiatry, University of Amsterdam; Institute for Psychotherapy ‘De Oosthoek’, Limmen, The Netherlands
P. M. A. J. Dingemans
Affiliation:
Department of Psychiatry, Leiden University; Department of Psychiatry, University of Amsterdam; Institute for Psychotherapy ‘De Oosthoek’, Limmen, The Netherlands
D. H. Linszen
Affiliation:
Department of Psychiatry, Leiden University; Department of Psychiatry, University of Amsterdam; Institute for Psychotherapy ‘De Oosthoek’, Limmen, The Netherlands
M. A. Nugter
Affiliation:
Department of Psychiatry, Leiden University; Department of Psychiatry, University of Amsterdam; Institute for Psychotherapy ‘De Oosthoek’, Limmen, The Netherlands
W. F. Scholte
Affiliation:
Department of Psychiatry, Leiden University; Department of Psychiatry, University of Amsterdam; Institute for Psychotherapy ‘De Oosthoek’, Limmen, The Netherlands
*
1 Address for correspondence: Dr A. J. W. Van der Does, Leiden University, Department of Psychiatry, Jelgersma Polikliniek, PO Box 1251, 2340 BG Oegstgeest, The Netherlands.
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Synopsis

The relationships among symptoms, cognitive functioning and social functioning were investigated in 60 patients with recent-onset schizophrenia. Positive symptoms were unrelated to cognitive measures. Disorganization and depressive symptoms were correlated significantly with Card Sorting performance. Furthermore, only negative symptoms were correlated significantly with social functioning. These results replicate earlier studies with chronic and mixed samples, and support the validity of disorganization as a separate symptom dimension. In contrast to most previous studies, no significant correlations were found between negative symptoms and cognitive measures. However, some evidence was found for a non-linear association between negative symptoms and several cognitive measures. The variation explained by a curvilinear model was not high, but for some cognitive measures this model was clearly superior to a linear model. If replicated, this finding supports the position that cross-sectionally measured negative symptoms cannot be viewed as a unitary concept.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 3 , August 1993 , pp. 745 - 753
Copyright
Copyright © Cambridge University Press 1993

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References

Addington, J. D., Addington, D. & Maticka-Tyndale, E. (1991). Cognitive functioning and positive and negative symptoms in schizophrenia. Schizophrenia Research 5, 123–134.CrossRefGoogle ScholarPubMed
American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. – Revised (DSM-III-R). APA: Washington, DC.Google Scholar
Andreasen, N. C. & Olsen, S. (1982). Negative v. positive schizophrenia: definition and validation. Archives of General Psychiatry 39, 789–794.CrossRefGoogle ScholarPubMed
Andreasen, N. C., Flaum, M., Swayze, V. W., Tyrell, G. & Arndt, S. (1990). Positive and negative symptoms in schizophrenia. A critical reappraisal. Archives of General Psychiatry 47, 615–621.CrossRefGoogle ScholarPubMed
Arndt, S., Alliger, R. J. & Andreasen, N. C. (1991). The distinction of positive and negative symptoms. The failure of a two-dimensional model. British Journal of Psychiatry 158, 317–322.CrossRefGoogle ScholarPubMed
Asarnow, R. F. & McCrimmon, D. J. (1981). Span of apprehension deficits during the postpsychotic stages of schizophrenia: a replication and extension. Archives of General Psychiatry 38, 1006–1011.CrossRefGoogle ScholarPubMed
Bellissimo, A. & Steffy, R. A. (1972). Redundancy-associated deficit in schizophrenic reaction time performance. Journal of Abnormal Psychology 85, 299–307.CrossRefGoogle Scholar
Carpenter, W. T., Heinrichs, D. W. & Wagman, A. M. I. (1988). Deficit and nondeficit forms of schizophrenia: the concept. American Journal of Psychiatry 145, 578–583.Google ScholarPubMed
Crow, T. J. (1980). Molecular pathology of schizophrenia: more than one disease process? British Medical Journal 280, 66–68.CrossRefGoogle ScholarPubMed
Green, M. & Walker, E. (1984). Susceptibility to backward masking in schizophrenic patients with positive and negative symptoms. American Journal of Psychiatry 141, 1273–1275.Google Scholar
Green, M. & Walker, E. (1986). Symptom correlates of vulnerability to backward masking in schizophrenia. American Journal of Psychiatry 143, 181–186.Google ScholarPubMed
Heaton, R. K. (1981). Wisconsin Card Sorting Test Manual. Psychological Assessment Resources: Odessa, FL.Google Scholar
Hemsley, D. R. (1977). What have cognitive deficits to do with schizophrenic symptoms? British Journal of Psychiatry 130, 167–173.CrossRefGoogle Scholar
Kay, S. R. (1990). Significance of the positive-negative distinction in schizophrenia. Schizophrenia Bulletin 16, 635–652.CrossRefGoogle ScholarPubMed
Krawiecka, M., Goldberg, D. & Vaughan, M. (1977). A standardized psychiatric assessment for rating chronic psychotic patients. Acta Psychiatrica Scandinavica 55, 299–308.CrossRefGoogle ScholarPubMed
Liddle, P. F. (1987 a). The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. British Journal of Psychiatry 151, 145–151.CrossRefGoogle ScholarPubMed
Liddle, P. F. (1987 b). Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychological Medicine 17, 49–57.CrossRefGoogle ScholarPubMed
Liddle, P. F. & Barnes, Th. R. E. (1990). Syndromes of chronic schizophrenia. British Journal of Psychiatry 157, 558–561.CrossRefGoogle ScholarPubMed
Liddle, P. F. & Morris, D. L. (1991). Schizophrenic syndromes and frontal lobe performance. British Journal of Psychiatry 158, 340–345.CrossRefGoogle ScholarPubMed
Lukoff, D., Nuechterlein, K. H. & Ventura, J. (1986). Manual for Expanded Brief Psychiatric Rating Scale (BPRS). Schizophrenia Bulletin 12, 594–602.Google Scholar
McGlashan, Th. H. & Fenton, W. S. (1992). The positive-negative distinction in schizophrenia. Review of natural history validators. Archives of General Psychiatry 49, 63–72.CrossRefGoogle ScholarPubMed
Merriam, A. E., Kay, S. R., Weiner, R. U. & Opler, L. A. (1990). Negative schizophrenic symptoms are associated with backward masking vulnerability. Schizophrenia Research 3, 355–356.CrossRefGoogle ScholarPubMed
Morrison-Stewart, S. L., Williamson, P. C., Corning, W. C., Kutcher, S. P., Snow, W. G. & Merskey, H. (1992). Frontal and non-frontal neuropsychological test performance and clinical symptomatology in schizophrenia. Psychological Medicine 22, 353–359.CrossRefGoogle ScholarPubMed
Nelson, H. E. (1976). A modified card sorting test sensitive to frontal lobe deficits. Cortex 12, 313–324.CrossRefGoogle Scholar
Nuechterlein, K. H. (1986). Expanded Version of the Present State Examination (PSE). University of California: Los Angeles.Google Scholar
Nuechterlein, K. H., Edell, W. S., Norris, M. & Dawson, M. E. (1986). Attentional vulnerability indicators, thought disorder, and negative symptoms. Schizophrenia Bulletin 12, 408–426.CrossRefGoogle ScholarPubMed
Overall, J. E. & Gorham, D. R. (1962). Brief Psychiatric Rating Scale. Psychological Reports 10, 799–812.CrossRefGoogle Scholar
Schwartz, F., Munich, R. L., Carr, A., Bartuch, E., Lesser, B., Rescigno, D. & Viegener, (1991). Negative symptoms and reaction time in schizophrenia. Journal of Psychiatric Research 25, 131–140.CrossRefGoogle ScholarPubMed
Spaulding, W., Garbin, C. P. & Dras, S. R. (1989). Cognitive abnormalities in schizophrenic patients and schizotypical college students. Journal of Nervous and Mental Disease 177, 717–728.CrossRefGoogle ScholarPubMed
Van der Does, A. J. W. & Van den Bosch, R. J. (1992). What determines Wisconsin Card Sorting performance in schizophrenia? Clinical Psychology Review 12, 567–583.CrossRefGoogle Scholar
Van der Does, A. J. W., Linszen, D. H., Dingemans, P. M., Nugter, M. A. & Scholte, W. F. (1993). A dimensional and categorical approach to the symptomatology of recent-onset schizophrenia. Journal of Nervous and Mental Disease (in the press).Google Scholar
Wagman, A. M. I., Heinrichs, D. W. & Carpenter, W. T. (1987). Deficit and nondeficit forms of schizophrenia: neuropsychological evaluation. Psychiatry Research 22, 319–330.CrossRefGoogle ScholarPubMed
Wiersma, D., De Jong, A. & Ormel, J. (1986). De Groningse Sociale Beperkingenschaal [Groningen Social Disability Schedule]. University of Groningen, Department of Social Psychiatry: Groningen.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge.Google Scholar
Wykes, T., Katz, R., Sturt, E. & Hemsley, D. (1992). Abnormalities of response processing in a chronic psychiatric group. British Journal of Psychiatry 160, 244–252.CrossRefGoogle Scholar