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Treatment of depression in diagnosed diabetes: common cause or detection bias?

Published online by Cambridge University Press:  21 August 2013

K. Manderbacka ,
M. Jokela ,
R. Sund  and
M. Elovainio
K. Manderbacka*
Affiliation:
National Institute for Health and Welfare, Service System Research Unit, Helsinki, Finland
M. Jokela
Affiliation:
Institute of Behavioral Sciences, University of Helsinki, Finland
R. Sund
Affiliation:
National Institute for Health and Welfare, Service System Research Unit, Helsinki, Finland
M. Elovainio
Affiliation:
National Institute for Health and Welfare, Service System Research Unit, Helsinki, Finland
*
* Address for correspondence: K. Manderbacka, Ph.D., National Institute for Health and Welfare, Service System Research Unit, PO Box 30, 00271 Helsinki, Finland. (Email: kristiina.manderbacka@thl.fi)
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Abstract

Background

This study examined two competing hypotheses concerning the association between diabetes and treatment for depression: (1) the detection/ascertainment bias hypothesis suggesting that those with diabetes are more likely to be diagnosed with and treated for depression because of increased medical attention and (2) a hypothesis assuming that diabetes and depression share common underlying pathophysiological pathways.

Method

The study population included all persons aged 35–65 years in Finland with any record of type 2 diabetes in the national health and population registers from 1999 to 2002 and for whom register-based data on depression treatment (antidepressant medication use and hospitalizations for depression) were available at least 2 years before and after the diagnosis of diabetes (n = 18 217). Sociodemographic data were individually linked to the study population. Associations between diabetes diagnosis and time and indicators of depression care were assessed with population-averaged multilevel logistic models.

Results

Within the year following diagnosis diabetes, there was a 5% increase in antidepressant medication use but not in hospitalization for depression. The longitudinal change in antidepressant use over time was less steep after the diabetes diagnosis, and hospitalization risk decreased after the diagnosis. These associations between diabetes diagnosis and depression treatment were not modified by the participant's socio-economic position (SEP).

Conclusions

These findings support the common cause hypothesis that treatment for diabetes is beneficial to the prevention of depression rather than the detection/ascertainment hypothesis that individuals with diabetes have higher rates of depression because they receive more medical attention in general.

Keywords

Depressiondiabetesregister-based study
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 6 , April 2014 , pp. 1205 - 1212
Copyright
Copyright © Cambridge University Press 2013 

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References

Ali, S, Stone, MA, Peters, JL, Davies, MJ, Khunti, K (2006). The prevalence of co-morbid depression in adults with Type 2 diabetes: a systematic review and meta-analysis. Diabetic Medicine 23, 1165–1173.Google Scholar
Anderson, RJ, Freedland, KE, Clouse, RE, Lustman, PJ (2001). The prevalence of comorbid depression in adults with diabetes. Diabetes Care 24, 1069–1078.CrossRefGoogle ScholarPubMed
Bell, RA, Smith, SL, Arcury, TA, Snively, BM, Stafford, JM, Quandt, SA (2005). Prevalence and correlates of depressive symptoms among rural older African Americans, Native Americans, and whites with diabetes. Diabetes Care 28, 823–829.Google Scholar
de Groot, M, Anderson, R, Freedland, KE, Clouse, RE, Lustman, PJ (2001). Association of depression and diabetes complications: a meta-analysis. Psychosomatic Medicine 63, 619–630.CrossRefGoogle ScholarPubMed
DiMatteo, RM (2004). Variations in patients’ adherence to medical recommendations. A quantitative review of 50 years of research. Medical Care 42, 200–209.Google Scholar
Dismuke, CE, Egede, LE (2010). Association between major depression, depressive symptoms and personal income in US adults with diabetes. General Hospital Psychiatry 32, 484–491.Google Scholar
Edwards, R, Burns, JA, McElduff, P, Young, RJ, New, JP (2003). Variations in process and outcomes of diabetes care by socio-economic status in Salford, UK. Diabetologia 46, 750–759.CrossRefGoogle ScholarPubMed
Engum, A, Mykletun, A, Midthjell, K, Holen, A, Dahl, AA (2005). Depression and diabetes: a large population-based study of sociodemographic, lifestyle, and clinical factors associated with depression in type 1 and type 2 diabetes. Diabetes Care 28, 1904–1909.Google Scholar
Gary-Webb, TL, Baptiste-Roberts, K, Pham, L, Wesche-Thobaben, J, Patricio, J, Pi-Sunyer, FX, Brown, AF, Jones-Corneille, L, Brancati, FL; the Look AHEAD Research Group (2011). Neighborhood socioeconomic status, depression, and health status in the Look AHEAD (Action for Health in Diabetes) Study. BMC Public Health 11, 349.Google Scholar
Hamer, M, Stamatakis, E, Kivimaki, M, Pascal Kengne, A, Batty, GD (2010). Psychological distress, glycated hemoglobin, and mortality in adults with and without diabetes. Psychosomatic Medicine 72, 882–886.CrossRefGoogle ScholarPubMed
Hanninen, JA, Takala, JK, Keinanen-Kiukaanniemi, SM (1999). Depression in subjects with type 2 diabetes. Predictive factors and relation to quality of life. Diabetes Care 22, 997–998.Google Scholar
Harjutsalo, V, Sjoberg, L, Tuomilehto, J (2008). Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 371, 1777–1782.CrossRefGoogle ScholarPubMed
Hedeker, D, Gibbons, RD (1997). Application of random-effects pattern-mixture models for missing data in longitudinal studies. Psychological Methods 2, 64–78.Google Scholar
Kivimaki, M, Batty, GD, Jokela, M, Ebmeier, KP, Vahtera, J, Virtanen, M, Brunner, EJ, Tabak, AG, Witte, DR, Kumari, M, Singh-Manoux, A, Hamer, M (2011). Antidepressant medication use and risk of hyperglycemia and diabetes mellitus: a noncausal association? Biological Psychiatry 70, 978–984.Google Scholar
Kivimaki, M, Gunnell, D, Lawlor, DA, Davey Smith, G, Pentti, J, Virtanen, M, Elovainio, M, Klaukka, T, Vahtera, J (2007). Social inequalities in antidepressant treatment and mortality: a longitudinal register study. Psychological Medicine 37, 373–382.Google Scholar
Kivimäki, M, Tabák, AG, Lawlor, DA, Batty, GD, Singh-Manoux, A, Jokela, M, Salo, P, Virtanen, M, Oksanen, T, Pentti, J, Witte, DR, Vahtera, J (2010). Antidepressant use before and after diagnosis of diabetes versus diagnosis of cancer. Diabetes Care 33, 1471–1476.Google Scholar
Knol, MJ, Geerlings, MI, Grobbee, DE, Egberts, AC, Heerdink, ER (2009). Antidepressant use before and after initiation of diabetes mellitus treatment. Diabetologia 52, 425–432.Google Scholar
Knol, MJ, Twisk, JW, Beekman, AT, Heine, RJ, Snoek, FJ, Pouwer, F (2006). Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia 49, 837–845.Google Scholar
Kogan, SM, Brody, GH, Chen, YF (2009). Depressive symptomatology mediates the effect of socioeconomic disadvantage on HbA(1c) among rural African Americans with type 2 diabetes. Journal of Psychosomatic Research 67, 289–296.CrossRefGoogle ScholarPubMed
Lammi, N, Blomstedt, PA, Moltchanova, E, Eriksson, JG, Tuomilehto, J, Karvonen, M (2008). Marked temporal increase in the incidence of type 1 and type 2 diabetes among young adults in Finland. Diabetologia 51, 897–899.Google Scholar
Manderbacka, K, Sund, R, Koski, S, Keskimaki, I, Elovainio, M (2011). Diabetes and depression? Secular trends in the use of antidepressants among persons with diabetes in Finland in 1997–2007. Pharmacoepidemiology and Drug Safety 20, 338–343.Google Scholar
Marcum, ZY, Zheng, Y, Perera, S, Strotmeyer, E, Newman, AB, Simonsick, E, Shor, RI, Bauer, DC, Donohue, JM, Hanlon, JT; for the Health ABC Study (2013). Prevalence and correlates of self-reported medication non-adherence among older adults with coronary heart disease, diabetes mellitus and/or hypertension. Research in Social and Administrative Pharmacy. Published online: 3 01 2013 . doi:10.1016/j.sapharm.2012.12.002.Google Scholar
McWilliams, JM, Meara, E, Zaslavsky, AM, Ayanian, JZ (2009). Differences in control of cardiovascular disease and diabetes by race, ethnicity, and education: U.S. trends from 1999 to 2006 and effects of Medicare coverage. Annals of Internal Medicine 150, 505–515.CrossRefGoogle Scholar
Nouwen, A, Winkley, K, Twisk, J, Lloyd, CE, Peyrot, M, Ismail, K, Pouwer, F; European Depression in Diabetes (EDID) Research Consortium (2010). Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia 53, 2480–2486.CrossRefGoogle ScholarPubMed
O'Connor, PJ, Crain, AL, Rush, WA, Hanson, AM, Fischer, LR, Kluznik, JC (2009). Does diabetes double the risk of depression? Annals of Family Medicine 7, 328–335.Google Scholar
OECD (2012). What are equivalence scales? (http://www.oecd.org/eco/growth/OECD-Note-EquivalenceScales.pdf). Accessed 20 June 2013.Google Scholar
Onkamo, P, Vaananen, S, Karvonen, M, Tuomilehto, J (1999). Worldwide increase in incidence of Type I diabetes – the analysis of the data on published incidence trends. Diabetologia 42, 1395–1403.Google Scholar
Passa, P (2002). Diabetes trends in Europe. Diabetes/Metabolism Research and Reviews 18, S3–S8.Google Scholar
Pirkola, S, Sohlman, B (2005). Atlas of Mental Health: Statistics from Finland. Stakes: Helsinki (http://www.mhfs.org.uk/resources/NMHW06/pdf/atlas%20stats%20finland.pdf). Accessed 20 June 2013.Google Scholar
Sund, R (2012). Quality of the Finnish Hospital Discharge Register: a systematic review. Scandinavian Journal of Public Health 40, 505–515.Google Scholar
Sund, R, Harno, K, Ranta, S, Tolppanen, E (2010). Evaluation of case inclusion in two population-based diabetes registers. Finnish Journal of eHealth and eWelfare 2, 136–146.Google Scholar
Sund, R, Koski, S (2009). FinDM II. On the register-based measurement of the prevalence and incidence of diabetes and its long-term complications. A technical report. (www.diabetes.fi/files/1167/DehkoFinDM_Raportti_ENG.pdf). Accessed 27 November 2012.Google Scholar
Talbot, F, Nouwen, A (2000). A review of the relationship between depression and diabetes in adults: is there a link? Diabetes Care 23, 1556–1562.Google Scholar
Viinamaki, H, Niskanen, L, Uusitupa, M (1995). Mental well-being in people with non-insulin-dependent diabetes. Acta Psychiatrica Scandinavica 92, 392–397.Google Scholar
Wamala, S, Merlo, J, Bostrom, G, Hogstedt, C, Agren, G (2007). Socioeconomic disadvantage and primary non-adherence with medication in Sweden. International Journal for Quality in Health Care 19, 134–140.Google Scholar
Wilf-Miron, R, Peled, R, Yaari, E, Shem-Tov, O, Weinner, VA, Porath, A, Kokia, E (2010). Disparities in diabetes care: role of the patient's socio-demographic characteristics. BMC Public Health 10, 729.Google Scholar