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Urinary excretion of the sulphate and glucuronide of 3-methoxy-4-hydroxyphenylethyleneglycol in a manic-depressive patient

Published online by Cambridge University Press:  09 July 2009

P. A. Bond ,
Maria Dimitrakoudi ,
D. R. Howlett  and
F. A. Jenner
P. A. Bond
Affiliation:
Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield
Maria Dimitrakoudi
Affiliation:
Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield
D. R. Howlett
Affiliation:
Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield
F. A. Jenner
Affiliation:
Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield
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Synopsis

The sulphate and glucuronide conjugates of 4-OH-3-methoxyphenylethyleneglycol (MOPEG) and 4-OH-3-methoxymandelic acid (VMA) have been serially studied in the urine of a manic-depressive patient before and after a therapeutic response to lithium carbonate. Excretion of both conjugates correlates with changes in mood. Some reasons to suggest that the sulphate might be a more useful measure of brain activity are stated.

Type
Original Article
Information
Psychological Medicine , Volume 5 , Issue 3 , August 1975 , pp. 279 - 285
Copyright
Copyright © Cambridge University Press 1975

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