Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-29T12:14:03.243Z Has data issue: false hasContentIssue false

Will schizophrenia become a graveyard for molecular geneticists?

Published online by Cambridge University Press:  09 July 2009

Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Editorials
Copyright
Copyright © Cambridge University Press 1992

References

Aschauer, H. N., Aschauer-Trieber, G., Isenberg, K. E., Todd, R. D., Knesevich, M. A., Garver, D. L., Reich, T. & Cloninger, C. R. (1990). No evidence for linkage between chromosome 5 markers and schizophrenia. Human Heredity 40, 109115.CrossRefGoogle ScholarPubMed
Baron, M., Endicott, J. & Ott, J. (1990). Genetic linkage in mental illness: limitations and prospects. British Journal of Psychiatry 157, 645655.CrossRefGoogle ScholarPubMed
Basset, A., McGillvray, B. C., Jones, B. D. & Pantzar, J. T. (1988). Partial trisomy chromosome 5 co-segregating with schizophrenia. Lancet i, 799801.CrossRefGoogle Scholar
Detera-Wadleigh, S. D., Goldin, L. R., Sherrington, R., Encio, I., de Miguel, C., Berrettini, W., Gurling, H. & Gershon, E. S. (1989). Exclusion of linkage to 5q11–13 in families with schizophrenia and other psychiatric disorders. Nature 340, 391392.CrossRefGoogle ScholarPubMed
Goate, A. M., Haynes, A. R., Owen, M. J., Farrall, M., James, L. A., Lai, L. Y. C., Mullan, M. J., Roques, P., Rossor, M. N., Williamson, R. & Hardy, J. A. (1989). Predisposing locus for Alzheimer's disease on chromosome 21. Lancet i, 355359.Google Scholar
Gottesman, I. I. & Shields, J. (1982). Schizophrenia: The Epigenetic Puzzle. Cambridge University Press: Cambridge.Google Scholar
Hall, J. M., Lee, M. K., Newman, B., Morrow, J. E., Anderson, L. A., Hyey, B. & King, M.-C. (1990). Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 16841689.CrossRefGoogle ScholarPubMed
Kaufman, C. A., DeLisi, E., Lehner, T. & Gilliam, T. C. (1989). Physical mapping, linkage analysis of the putative schizophrenia locus on chromosome 5q. Schizophrenia Bulletin 15, 441452.CrossRefGoogle Scholar
Kelsoe, J. R., Ginns, E. I., Egeland, J. A., Gerhard, D. S., Goldstein, A. M., Bale, S. J., Pauls, D. L., Long, R. T., Kidd, K. K., Conte, G., Housman, D. E. & Paul, S. M. (1989). Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342, 238243.CrossRefGoogle ScholarPubMed
Kendler, K. S. (1987). The feasibility of linkage studies in schizophrenia. In Biological Perspectives of Schizophrenia (ed. Helmchen, H. and Henn, F. A.). John Wiley and Sons: Chichester.Google Scholar
Kennedy, J. L., Giuffra, L. A., Moises, H. W., Cavalli-Sforza, L. L., Pakstis, H. J., Kidd, J. R., Castiglione, C. M., Wetterberg, L. & Kidd, K. K. (1988). Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 336, 167170.CrossRefGoogle Scholar
Lander, E. S. (1988). Splitting schizophrenia. Nature 336, 105106.CrossRefGoogle ScholarPubMed
Leboyer, M., Malafosse, A., Boularand, S., Campion, D., Gheysen, F., Somolyk, D., Henriksson, B., Denise, E., des Lauriers, A., Lepine, J. P., Zarfian, E., Clerget-Darpoux, F. & Mallet, J. (1990). Tyrosine hydroxylase polymorphisms associated with manic-depressive illness. Lancet, 335, 1219.CrossRefGoogle ScholarPubMed
McGue, M. & Gottesman, I. I. (1989). Genetic linkage in schizophrenia: perspectives from genetic epidemiology. Schizophrenia Bulletin 15, 453464.CrossRefGoogle ScholarPubMed
McGue, M., Gottesman, I. I. & Rao, D. C. (1985). Resolving genetic models for the transmission of schizophrenia. Genetic Epidemiology 2, 99110.CrossRefGoogle ScholarPubMed
McGuffin, P. (1988). Genetics of schizophrenia. In Schizophrenia: The Major Issues (ed. Bebbington, P. and McGuffin, P.), pp. 107126. Heinemann Medical: London.Google Scholar
McGuffin, P. & Sturt, E. (1986). Genetic markers in schizophrenia. Human Heredity 36, 6588.CrossRefGoogle ScholarPubMed
McGuffin, P., Farmer, A. & Gottesman, I. I. (1987). Is there really a split in schizophrenia? The genetic evidence. British Journal of Psychiatry 150, 581592.CrossRefGoogle ScholarPubMed
McGuffin, P., Sargeant, M., Hett, G., Tidmarsh, S., Whatley, S. & Marchbanks, R. M. (1990). Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11–q13 region. New data and reanalysis of previous reports. American Journal of Human Genetics 47, 524535.Google ScholarPubMed
Martinez, M. M. & Goldin, L. R. (1989). The detection of linkage and heterogeneity in nuclear families for complex disorders; 1 v. 2 marker loci. American Journal of Human Genetics 44, 552559.Google Scholar
Morton, N. E. (1955). Sequential tests for the detection of linkage. American Journal of Human Genetics 7, 277318.Google ScholarPubMed
Morton, N. E. (1982). Outline of Genetic Epidemiology. Karger: Basel.Google Scholar
Ott, J. (1989). Computer-simulation methods in human linkage analysis. Proceedings of the National Academy of Sciences, USA, 86, 41754178.CrossRefGoogle ScholarPubMed
Owen, M. J. & Mullan, M. J. (1990). Molecular genetic studies of manic-depression and schizophrenia. Trends in Neuroscience 13, 2931.CrossRefGoogle ScholarPubMed
Owen, M. J. & Whatley, S. A. (1988). Polymorphic DNA markers and mental disease. Psychological Medicine 18, 529533.CrossRefGoogle ScholarPubMed
Owen, M. J. & McGuffin, P. (1991). DNA and classical genetic markers in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 240, 197203.CrossRefGoogle ScholarPubMed
Owen, M. J., Crawford, D. & St. Clair, D. (1990). Localization of a susceptibility locus for schizophrenia on chromosome 5. British Journal of Psychiatry 157, 123127.CrossRefGoogle ScholarPubMed
Plomin, R. (1990). The role of inheritance in behaviour. Science, 248, 183188.CrossRefGoogle Scholar
Plum, F. (1972). Prospects for research on schizophrenia. 3. Neurophysiology, neuropathological findings. Neurosciences Research Program Bulletin 10, 384388.Google ScholarPubMed
St. Clair, D., Blackwood, D., Muir, W., Baillie, D., Hubbard, S., Wright, A. & Evans, H. J. (1989). No linkage of chromosome 5q11–q13 markers to schizophrenia in Scottish families. Nature 339, 305309.CrossRefGoogle ScholarPubMed
St. George-Hyslop, P. H., Tanzi, R. E., Polinsky, R. J., Haines, J. L., Drachman, D., Growdon, J., Bruni, A., Foncin, J.-F., Salmon, D., Frommelt, P., Amaducci, L., Sorbi, S., Piacentini, S., Stewart, G. D., Hobbs, W. J., Conneally, M. & Gusella, J. F. (1987). The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 235, 885890.CrossRefGoogle ScholarPubMed
St. George-Hyslop, P. H., Haines, J. L., Farrer, L. A., Polinsky, R., Van Broeckhoven, C., Goate, A., Crapper-McLachlan, D. R., Orr, H., Monesi, N. P., Sorbi, S., Rainero, I., Foncin, J.-F., Pollen, D., Cantu, J.-M., Vartanjan, M., Mayeux, R., Nee, L., Backhovens, H., Martin, J.-J., Rossor, M. N., Owen, M. J., Mullan, M., Percy, M. E., Karlinsky, H., Rich, S., Growdon, J., Heston, L., Gusella, J. F. & Hardy, J. A., (1990). Genetic linkage studies suggest that Alzheimer's disease is not a single homogenous disorder. Nature, 347, 194197.CrossRefGoogle ScholarPubMed
Sherrington, R., Brynjolfsson, J., Petursson, H., Potter, M., Dudleston, K., Barraclough, B., Wasmuth, J., Dobbs, A. & Gurling, H. (1988). Localization of susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164167.CrossRefGoogle ScholarPubMed
Sturt, E. & McGuffin, P. (1985). Can linkage and marker association resolve the genetic aetiology of psychiatric disorders: review and argument. Psychological Medicine 15, 455462.CrossRefGoogle ScholarPubMed
Tattersall, R. B. & Fajans, S. (1975). A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people. Diabetes 24, 4453.CrossRefGoogle ScholarPubMed
Todd, J. A., Bell, J. I. & McDevitt, H. O. (1988). A molecular basis for genetic susceptibility to insulin-dependent diabetes mellitus. Trends in Genetics 4, 129134.CrossRefGoogle ScholarPubMed
Weber, J. L. & May, P. E. (1989). Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. American Journal of Human Genetics 44, 388396.Google ScholarPubMed
Whatley, S. A. & Owen, M. J. (1989). The application of molecular genetics to psychiatric disorder. International Review of Psychiatry 1, 219230.CrossRefGoogle Scholar
Wojciechowski, A. P., Farrall, M., Cullen, P., Wilson, T. M. E., Bayliss, J. D., Farren, B., Griffin, B. A., Caslake, M. J., Packard, C. J., Shepherd, J., Thakker, R. & Scott, J. (1991). Familial combined hyperlipidaemia linked to the apolipoprotein AI-CIII-AIV gene cluster on chromosome 11q23–q24. Nature 349, 161164.CrossRefGoogle Scholar