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β-2 adrenergic receptor gene variations and blood pressure under stress in normal twins

Published online by Cambridge University Press:  30 April 2001

GUO-HUA LI ,
HANS-DIETER FAULHABER ,
MAGDA ROSENTHAL ,
HERBERT SCHUSTER ,
JENS JORDAN ,
BERND TIMMERMANN ,
MARGRET R. HOEHE ,
FRIEDRICH C. LUFT  and
ANDREAS BUSJAHN
GUO-HUA LI
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
HANS-DIETER FAULHABER
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
MAGDA ROSENTHAL
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
HERBERT SCHUSTER
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
JENS JORDAN
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
BERND TIMMERMANN
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
MARGRET R. HOEHE
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
FRIEDRICH C. LUFT
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
ANDREAS BUSJAHN
Affiliation:
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany
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Abstract

We tested the hypothesis that blood pressure (BP) responses to physical and mental stress are associated with polymorphisms in the β-2 adrenergic receptor (AR) gene. We studied normotensive, young, monozygotic (MZ) and dizygotic (DZ) twins. The subjects underwent automated BP measurements at the brachial and digital arteries and were subjected to mental arithmetic and cold pressor stress. We used allele-specific PCR to genotype four single nucleotide polymorphisms in the β-2 AR gene. The most functionally relevant polymorphism in the β-2 AR gene, Arg16/Gly, was associated with systolic and diastolic BP under resting conditions, during mental arithmetic, and during the cold pressor test, as well as with the increase in diastolic BP during both forms of stress. These findings support a role for the β-2 AR gene in BP regulation. They also indicate that the β-2 AR gene influences the level of not only resting but also stress-related BP.

Keywords

β-2 adrenergic receptorMolecular geneticsTwinsBlood pressure regulationStressReactivity
Type
Research Article
Information
Psychophysiology , Volume 38 , Issue 3 , May 2001 , pp. 485 - 489
Copyright
2001 Society for Psychophysiological Research

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