Individual differences in P3 scalp distribution in older adults, and their relationship to frontal lobe function

Abstract

There is evidence that frontal lobe function may diminish in normal aging. The P3 component of the event-related brain potential (ERP) elicited by target events in an oddball paradigm becomes more frontally oriented in elderly subjects. It was hypothesized that the extent to which the P3 distribution is frontally oriented in old subjects may index less efficient frontal lobe function. In this study, bootstrapping methods were used to establish the reliability of the locations of maxima of surface brain activity obtained with ERP recordings from young and old subjects. The results indicated that brain activity maxima are reliable for a given individual. However, among the elderly only, there were also clear individual differences in the distribution of the P3 component elicited by target stimuli in an oddball paradigm. On the basis of these differences, the old subjects were divided into two groups. In line with predictions, those elderly subjects who showed frontal-maximal P3 scalp distributions had lower performance on standardized neuropsychological tests of frontal lobe function than those elderly subjects who showed posterior-maximal scalp topographies.