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Ecological variation of intake of cassava food and dietary cyanide load in Nigerian communities

Published online by Cambridge University Press:  02 January 2007

AO Onabolu ,
OSA Oluwole ,
M Bokanga  and
H Rosling
AO Onabolu*
Affiliation:
International Institute of Tropical Agriculture (IITA), c/o LW Lambourn & Co., 26 Dingwall Road, Croydon CR9 3EE, UK: Division of International Health, Department of Public Health Sciences, Karolinska Institute, SE-171 76 Stockholm, Sweden:
OSA Oluwole
Affiliation:
International Institute of Tropical Agriculture (IITA), c/o LW Lambourn & Co., 26 Dingwall Road, Croydon CR9 3EE, UK: Division of International Health, Department of Public Health Sciences, Karolinska Institute, SE-171 76 Stockholm, Sweden: Neurology Unit, Department of Medicine, University of Ibadan, Ibadan, Nigeria
M Bokanga
Affiliation:
International Institute of Tropical Agriculture (IITA), c/o LW Lambourn & Co., 26 Dingwall Road, Croydon CR9 3EE, UK:
H Rosling
Affiliation:
Division of International Health, Department of Public Health Sciences, Karolinska Institute, SE-171 76 Stockholm, Sweden:
*
*Corresponding author: Email aonabolu@hotmail.com
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Abstract

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Aim:

To study the ecological variation of intake of cassava foods and dietary cyanide load.

Design:

Ecological study design.

Setting:

Five communities in south-western Nigeria where tropical ataxic neuropathy (TAN) was described as endemic (area A), 11 communities in south-western Nigeria where TAN was described as absent (area B), and five communities in northern Nigeria (area C).

Subjects:

Subjects were randomly sampled from selected communities. Intake of cassava foods was estimated from dietary history and dietary cyanide load was estimated from urine thiocyanate concentrations. Residual cyanogens in cassava food samples from the community markets were determined.

Results:

In total, 1272 subjects from 21 communities – 238 from area A, 659 from area B and 375 from area C – were selected. Intake of cassava food per person per week was 17 meals in area A, 10 meals in area B, and one meal in area C. Geometrical mean urine thiocyanate concentrations were 73 μmol l−1, 51 μmol l−1 and 17 μmol l−1 in areas A, B and C, respectively. Mean residual cyanogen content in cassava food samples was 16 mg HCN eq kg−1 (confidence interval (CI) 13–18) in area A, and 13 mg HCN eq kg−1 in area B (CI 11–14).

Conclusion:

This study shows that the intake of cassava foods and dietary cyanide load is high in several communities in south-western Nigeria, predominantly in communities where TAN has been reported. Dietary cyanide load in these communities appears to be determined by the combination of frequency of intake and cyanogen content of cassava foods. Measures to improve the effectiveness of removal of cyanogen from cassava roots during processing are needed in the affected communities.

Keywords

Cassava cyanogensDietary cyanideThiocyanateTropical ataxic neuropathy (TAN)
Type
Research Article
Information
Public Health Nutrition , Volume 4 , Issue 4 , August 2001 , pp. 871 - 876
Copyright
Copyright © CABI Publishing 2001

References

1Bellotti, A, Smith, L, Lapointe, S. Recent advances in pest management Annu. Rev. Entomol. 1999; 44: 343–70.CrossRefGoogle ScholarPubMed
2McMahon, J, White, W, Sayre, R. Cyanogenesis in cassava (Manihot esculenta Crantz) J. Exp. Botany 1995; 46: 731–41.CrossRefGoogle Scholar
3Spencer, PS. Food toxins, AMPA receptors, and motor neuron diseases Drug Metab. Rev. 1999; 31: 561–87.CrossRefGoogle ScholarPubMed
4Mlingi, N, Abrahamsson, M, Yuen, J, Gebre-Medhin, M, Rosling, H. Low cyanide exposure from consumption of cassava in Dar es Salaam, Tanzania Nat. Toxins 1998; 6: 67–72.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
5Banea-Mayambu, J. High cassava consumption without cyanide exposure in Kinshasa, in former Zaire Ecol. Food Nutr. 1998; 37: 363–73.CrossRefGoogle Scholar
6Rosling, H. Measuring effects in humans of dietary cyanide exposure from cassava Acta Horticult. 1994; 375: 271–83.CrossRefGoogle Scholar
7Onabolu, A, Bokanga, M, Rosling, H. Cassava processing in a Nigerian community affected by a neuropathy attributed to dietary cyanide exposure Trop. Sci. 1999; 39: 129–35.Google Scholar
8Bokanga, M. Distribution of cyanogenic potential in cassava germplasm Acta Horticult. 1994; 375: 117–23.CrossRefGoogle Scholar
9Osuntokun, B. Epidemiology of tropical nutritional neuropathy in Nigerians Trans. R. Soc. Trop. Med. Hyg. 1971; 65: 454–79.CrossRefGoogle ScholarPubMed
10Román, GC, Spencer, PS, Schoenberg, BS. Tropical myeloneuropathies: the hidden endemias Neurology 1985; 35: 1158–70.CrossRefGoogle ScholarPubMed
11Tylleskar, T, Banea, M, Bikangi, N, Cooke, RD, Poulter, NH, Rosling, H. Cassava cyanogens and konzo, an upper motoneuron disease found in Africa Lancet 1992; 339: 208–11.CrossRefGoogle ScholarPubMed
12Osuntokun, BO. Cassava diet, chronic cyanide intoxication and neuropathy in the Nigerian Africans World Rev. Nutr. Diet 1981; 36: 141–73.CrossRefGoogle ScholarPubMed
13Osuntokun, B. Chronic cyanide intoxication of dietary origin and a degenerative neuropathy in Nigerians Acta Horticult. 1994; 375: 311–21.CrossRefGoogle Scholar
14Money, G. Endemic neuropathies in the Epe district of southern Nigeria West Afr. Med. J. 1958; 7: 58–62.Google Scholar
15Monekosso, G. Clinical epidemiological observations on ataxic syndrome in Western Nigeria Trop. Geog. Med. 1963; 4: 316–23.Google Scholar
16Oluwole, OSA, Onabolu, AO, Link, H, Rosling, H. Persistence of tropical ataxic neuropathy in a Nigerian community J. Neurol. Neurosurg. Psychiat. 2000; 69: 96–101.CrossRefGoogle Scholar
17Osuntokun, B, Monekosso, G, Wilson, J. Relationship of a degenerative tropical neuropathy to diet report of a field survey BMJ 1969; 1: 547–50.CrossRefGoogle ScholarPubMed
18Food and Agricultural Organisation. Cassava. Food Outlook 2000; 19–22.Google Scholar
19Onabolu, A, Tylleskar, T, Bokanga, M, Rosling, H. High cassava production and low dietary cyanide exposure in Mid-West Nigeria Public Health Nutr. 2001; 4(1), 3–9.CrossRefGoogle ScholarPubMed
20Essers, A, Bosveld, M, Van der Grift, R, Voragen, A. Studies on the quantification of specific cyanogens in cassava products and introduction of a new chromogen J. Sci. Food Agric. 1993; 63: 287–96.CrossRefGoogle Scholar
21Lundquist, P, Kagedal, B, Nilsson, L. An improved method for determination of thiocyanate in plasma and urine Eur. J. Clin. Chem. Clin. Biochem. 1995; 33: 343–49.Google ScholarPubMed
22Carter, S, Jones, P. A model of the distribution of cassava in Africa Appl. Geog. 1993; 13: 353–71.CrossRefGoogle Scholar
23Chiwona-Karltun, L, Tylleskär, T, Mukumbira, J, Gebre-Medhin, M, Rosling, H. Low dietary cyanogen exposure from frequent consumption of potentially toxic cassava in Malawi Int. J. Food Sci. Nutr. 2000; 51: 33–43.CrossRefGoogle ScholarPubMed