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Serum carotenoids and radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project

Published online by Cambridge University Press:  02 January 2007

Anneclaire J De Roos ,
Lenore Arab ,
Jordan B Renner ,
Neal Craft ,
Gheorghe Luta ,
Charles G Helmick ,
Marc C Hochberg  and
Joanne M Jordan
Anneclaire J De Roos
Affiliation:
National Cancer Institute, Bethesda, MD, USA
Lenore Arab
Affiliation:
Thurston Arthritis Research Center, Department of Epidemiology and Nutrition, University of North Carolina School of Public Health, Chapel Hill, NC, USA
Jordan B Renner
Affiliation:
Thurston Arthritis Research Center, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Neal Craft
Affiliation:
Craft Technologies, Inc., Wilson, NC, USA.
Gheorghe Luta
Affiliation:
Thurston Arthritis Research Center, Department of Biostatistics, University of North Carolina School of Public Health, Chapel Hill, NC, USA
Charles G Helmick
Affiliation:
Centers for Disease Control and Prevention, Atlanta, GA, USA
Marc C Hochberg
Affiliation:
Departments of Medicine, Epidemiology, and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Joanne M Jordan*
Affiliation:
Thurston Arthritis Research Center, 3310 Doc J Thurston Jr Building, CB* 7330, University of North Carolina, Chapel Hill, NC 27599-7330, USA
*
*Corresponding author: Email joanne_jordan@med.unc.edu
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Abstract

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Objective:

Antioxidant intake has been associated with less progression of radiographic knee osteoarthritis (OA), but studies of carotenoid biomarkers and OA have not been done. We examined associations between serum concentrations of nine naturally occurring carotenoids and radiographic knee OA.

Design:

The study design was matched case–control. Sera were analysed by high-performance liquid chromatography for nine carotenoids: lutein, zeaxanthin, α- and β-cryptoxanthin, trans- and cis-lycopene, α-carotene, and trans- and cis-β-carotene. Conditional logistic regression was used to estimate the association between tertiles of each carotenoid and radiographic knee OA, independent of body mass index, education, serum cholesterol, and the other carotenoids.

Setting:

Johnston County, North Carolina, United States of America.

Subjects:

Two-hundred cases with radiographic knee OA (Kellgren–Lawrence grades ≥2) and 200 controls (Kellgren–Lawrence grade = 0) were randomly selected from the Johnston County Osteoarthritis Project, and were matched on age, gender and race.

Results:

Participants with serum levels of lutein or β-cryptoxanthin in the highest tertile were approximately 70% less likely to have knee OA than controls {odds ratio (OR) [95% confidence interval (CI)] = 0.28 [0.11, 0.73] and 0.36 [0.14, 0.95], respectively}. Those in the highest tertile of trans-β-carotene (OR = 6.40 [1.86, 22.1]) and zeaxanthin (OR = 3.06 [1.19, 7.85]) were more likely to have knee OA.

Conclusions:

While certain carotenoids may protect against knee OA, others may increase the odds of knee OA. Further study of carotenoids and knee OA are warranted before clinical recommendations about these substances and knee OA can be made.

Keywords

CarotenoidsKnee osteoarthritisRadiographic osteoarthritisAntioxidantsBiomarkers
Type
Research Article
Information
Public Health Nutrition , Volume 4 , Issue 5 , October 2001 , pp. 935 - 942
Copyright
Copyright © CABI Publishing 2001

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