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Linkage graphs: a study in the thermodynamics of macromolecules*

Published online by Cambridge University Press:  17 March 2009

Jeffries Wyman
Jeffries Wyman
Affiliation:
CNR Center for Molecular Biology, Istituto di Chimica Facoltà di Medicina, Università di RomaI 00185 Rome Italy, and Department of Chemistry, University of Colorado, Boulder, CO 80309
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Extract

In earlier papers (Wyman, 1975a, b, 1981) I have called attention to the existence of a group of linkage potentials derivable from one another by a corresponding group of Legendre transformations. These potentials are applicable to any system in a state of equilibrium but are especially useful in the study of the behaviour, or, as we may say, the functional chemistry, of a macromolecule in the presence of its ligands. In this paper I show how these potentials may be represented by a set of contour graphs which embody the results of observation and are transformable into one another by a group of graphical permutations equivalent to the Legendre group.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 17 , Issue 4 , November 1984 , pp. 453 - 488
Copyright
Copyright © Cambridge University Press 1984

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References

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