Addressing the challenges of cellular delivery and bioavailability of peptide nucleic acids (PNA)

Peter E. Nielsen

doi:10.1017/S0033583506004148

Abstract

1. Introduction 345

2. Peptide nucleic acid (PNA) 346

3. ‘Cell penetrating peptides’ (CPPs) 346

4. Endosomal escape 347

5. Cellular delivery of PNA 347

6.In vivobioavailability of PNA 349

7. References 350

Recent results on the cellular delivery of antisense peptide nucleic acids (PNA) via peptide conjugation is briefly discussed, in particular in the context of endosomal entrapment and escape.

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Addressing the challenges of cellular delivery and bioavailability of peptide nucleic acids (PNA)

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