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Constraints on the accuracy of messenger RNA movement

Published online by Cambridge University Press:  17 March 2009

C. G. Kurland  and
Måns Ehrenberg
C. G. Kurland
Affiliation:
Department of Molecular Biology, The Biomedical Center, Box 590, S-751 24 Uppsala, Sweden
Måns Ehrenberg
Affiliation:
Department of Molecular Biology, The Biomedical Center, Box 590, S-751 24 Uppsala, Sweden
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Summary

Theoretical as well as experimental studies of translational accuracy have most often been concerned with the selection of aminoacyl-tRNA by codon-programmed ribosomes. The selection of the successive codons on the mRNA has received much less attention, probably because it represents both conceptually and experimentally, a much more demanding physical problem. Nevertheless, it would seem that errors in the selection of the codon are potentially much more destructive than errors in selection of aminoacyl-tRNA species. This can be appreciated from the following.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 18 , Issue 4 , November 1985 , pp. 423 - 450
Copyright
Copyright © Cambridge University Press 1985

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References

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