Hostname: page-component-6bb9c88b65-g7ldn Total loading time: 0 Render date: 2025-07-23T21:58:31.465Z Has data issue: false hasContentIssue false
  • English
  • Français

Free radicals and the action of inhibitors of radical processes under pathological states and ageing in living organisms and in man

Published online by Cambridge University Press:  17 March 2009

N. M. Emanuel
N. M. Emanuel
Affiliation:
Institute of Chemical Physics, Academy of Sciences, USSR, Moscow, USSR
Get access Rights & Permissions [Opens in a new window]

Extract

The concept of processes in a living organism as of a most complex enzyme-catalysed system of coupled chemical conversions following both physical and chemical laws, opens up new possibilities of cognizance and control of vital processes.

Information

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 9 , Issue 2 , May 1976 , pp. 283 - 308
Copyright
Copyright © Cambridge University Press 1976

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

Alexander, P. (1956). Progress in Cancer Research 2, p. 114.Google Scholar
Boikova, V. I., Gurevich, S. M., Tereshchenko, I. P. & Saprin, A. N. (1972). Changes in the free radical contents and activity of some enzymes in mice mammary gland tissues caused by the development of spontaneous cancer. Izv. Akad. Nauk. SSSR (seriya biol.), 737–41.Google Scholar
Brennan, M. J., Cole, T., Singley, J., Hodgkinson, C. P. (1965). Electron spin resonance spectra of normal and neoplastic mouse tissues. Fedn Proc. Fedn Am. Socs exp. Biol. 24, 437.Google Scholar
Commoner, B., Townsend, J. & Pake, G. E. (1954). Free radicals in biological materials. Nature, Lond. 174, 689–91.CrossRefGoogle ScholarPubMed
Emanuel, N. M. (1973). Kinetics and the free-radical mechanisms of tumour growth. Ann. N.Y. Acad. Sci. 222, 1010.CrossRefGoogle Scholar
Emanuel, N. M. (1974 a). General pattern of change in the content of free radicals during malignant growth. Dokl. Akad. Nauk. SSSR 217, 245–8.Google Scholar
Emanuel, N. M. (1974 b). Kinetics and the free radical mechanisms of tumour growth. Izv. Akad. Nauk. SSSR. (seriya biol.) 773–84.Google Scholar
Emanuel, N. M. & Lipchina, L. P. (1958). Leucosis in mice and its development during interaction with inhibitors of chain oxidative processes. Dokl. Akad. Nauk. SSSR 121, 141–4.Google Scholar
Emanuel, N. M., Obukhova, L. K., Smirnov, L. D. & Bunto, T. V. (1975). Dokl. Akad. Nauk. SSSR (in the Press).Google Scholar
Emanuel, N. M., Saprin, A. N., Shabalkin, V. A., Kozlova, L. E. & Kruglyakova, K. E. (1969). Detection and investigation of a new type of ESR signal characteristic of some tumour tissue. Nature, Lond. 222, 165–7.CrossRefGoogle Scholar
Emanuel, N. M., Saprin, A. N., Shulyaxovskaya, T. S., Kozlova, L. E. & Bunto, T. V. (1973 a). Mechanism of the anticarcinogenic effect of the inhibitor of free radical processes 2,6-di-tert-butyl-4-methylphenol. Dokl. Akad. Nauk. SSSR 209, 1449–51.Google Scholar
Emanuel, N. M., Shulyakovskaya, T. S. & Kondratjeva, V. A. (1973 b). Change in the free radical level in organism tissues during the toxic action of chemical compounds. Dokl. Akad. Nauk. SSSR 209, 1213–14.Google Scholar
Frankfuet, O. S., Lipchina, L. P., Bunto, T. V. & Emanuel, N. M. (1967). Effect of 2,6-dil-tert-butyl-4-methylphenol (ionol) on the development of hepatic tumours in rats. Bull. exper. biol. medicini 64, 86–8.Google Scholar
Freidreich, E. C. (1966). XIth Congress of the International Society of Haematology, Sydney, p. 62.Google Scholar
Kassirskii, I. A., Emanuel, N. M., Klochko, E. V., Pinzur, V. I. & Kruglyakova, K. E. (1967). Problemy gematologii i perelivaniya krovi, no. 8, p. 11.Google Scholar
Klochko, E. V., Koval'chuk, L. V., Kruglyakova, K. E., Seits, I. F., Luganova, I. S., Blinov, M. N. & Emanuel, N. M. (1970). Free radicals and energy exchange in leukocytes during leukosis. Dokl. Akad. Nauk. SSSR 190, 476–9.Google Scholar
Kogan, A. Ch., Saprin, A. N. & Sizykh, A. S. (1971 a). Symposium: Free Radical States and Their Role in Radiation Damage and Malignant Growth, Moscow, p. 90.Google Scholar
Kogan, A. Ch., Sizykh, A. S. & Saprin, A. N. (1971 b). Symposium: Ultra Weak Luminescence in Medicine and Agriculture, Moscow, p. 18.Google Scholar
Kogan, A. Ch., Sizykh, A. S. & Saprin, A. N. (1972). IVth International Biophysics Congress, Moscow. Abstracts, v. 4, p. 207.Google Scholar
Kolomijtseva, I. K., L'vov, K. M. & Kajutshin, L. P. (1970). Determination of free radicals in tissues of rats inoculated with Sarcoma 45*. Biophysica 5, 636–7.Google Scholar
Konovalova, N. P., Bogdanov, G. N., Miller, V. B., Neiman, M. B., Rozantsev, E. G. & Emanuel, N. M. (1964). Antitumour activity of stable free radicals. Dokl. Akad. Nauk. SSSR 157, 707–9.Google Scholar
Kuzin, M. I., Emanuel, N. M., Shkrob, O. S. & Zaitsev, M. V. (1971). Symposium: Free Radical States and Their Role in Radiation Damage and Malignant Growth, Moscow, p. 52.Google Scholar
Murakami, K. & Mason, H. S. (1967). An electron spin resonance study of microsomal Fe*x. J. biol. Chem. 242, 1102–10.CrossRefGoogle Scholar
Pavlova, N. I. & Livenson, A. R. (1965). Electron spin resonance spectra of human normal and leukaemia blood. Biofizica 10, 169-71.Google Scholar
Petyaev, M. M., Reznikov, S. A., Cherepneva, I. E., Synsina, T. G. & Tereshchenko, T. U. (1967). Free radicals and tumour growth in sarcoma. Vop. Onkol. 13, 108–12.Google Scholar
Saprin, A. N., Kholmtjkhamedova, N. M., Ageenko, A. I. & Emanuel, N. M. (1971). Symposium: Free Radical States and Their Role in Radiation Damage and Malignant Growth, Moscow, p. 77.Google Scholar
Saprin, A. N., Klochko, E. V., Chibrikin, V. M., Kruglyakova, K. E. & Emanuel, N. M. (1966 a). Kinetics of the change in the content of free radicals in mouse organs in experimental leukosis. Dokl. Akad. Nauk. SSSR 167, 222–4.Google Scholar
Saprin, A. N., Klochko, E. V., Chibrikin, V. M., Kruglyakova, K. E. & Emanuel, N. M. (1966 b). Changes in free radical content during malignant growth and action of inhibitors of radical processes. Biofizika 11, 433–52.Google ScholarPubMed
Saprin, A. N., Shabalkin, V. A., Kozlova, L. E., Kruglyakova, K. E. & Emanuel, N. M. (1968). Discovery and study of a new type of ESR signals typical of a number of neoplastic tissues. Dokl. Akad. Nauk. SSSR 181, 1520.Google Scholar
Saprin, A. N. & Shulakovskaya, T. S. (1969). Emergence of a new type of EPR signals in animal tissues during the action of a series of chemical agents and during necrosis. Dokl. Akad. Nauk. SSSR 189, 889–91.Google Scholar
Shamberger, R. I. (1970). Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis. J. natn. Cancer Inst. 44, 931–6.Google ScholarPubMed
Shamberger, R. I., Baughman, F. F., Kalchert, S. L., Willis, C. E. & Hoffman, G. C. (1973). Carcinogen-induced chromosomal breakage decreased by antioxidants. PNAS 70, 1461–3.CrossRefGoogle ScholarPubMed
Shapiro, A. B., Kropacheva, A. A., Suskina, V. I., Rozynov, B. V. & Rozantzev, E. G. (1971). Mass spectrometric study of paramagnetic derivatives of ethylenephosphamides. Izv. Akad. Nauk SSSR. seriya chim. 864–7.Google Scholar
Shulyakovskaya, T. S., Saprin, A. N. & Emanuel, N. M. (1973). Effects of chemical compounds with varying toxicity on the content of free radicals and microsomal system of non-specific oxidases in the liver of animals. Dokl. Akad. Nauk SSSR 210, 221–3.Google Scholar
Shulyakovskaya, T. S., Vlasova, S. A., Saprin, A. N., Kruglyakova, K. E. & Emanuel, N. M. (1971). Symposium: Free Radical States and Their Role in Radiation Damage and Malignant Growth, Moscow, p. 95.Google Scholar
Truby, F. K. & Goldzicher, J. (1958). Electron spin resonance investigations of rat liver and rat hepatoma. Nature, Lond. 182, 1371–2.CrossRefGoogle ScholarPubMed
Vithayathil, A. J., Ternberg, J. L. & Commoner, B. (1965). Changes in electron spin resonance signals of rat liver during chemical carcinogenesis. Nature, Lond. 207, 1246–9.CrossRefGoogle ScholarPubMed
Wada, F., Higashi, T., Ichitawa, Y., Tada, K. & Sakamoto, Y. (1964). The relationship between electron spin resonance signals and haemoprotein of liver microsomes. Biochim. biophys. Acta 88, 654–5.Google ScholarPubMed
Wallace, J. D., Driscoll, D. H., Kalomiris, C. G. & Neaves, A. (1970). A study of free radicals occurring in tumourous female breast tissue and their implication to detection. Cancer, N.Y. 25, 1087–90.3.0.CO;2-B>CrossRefGoogle ScholarPubMed
Wattenberg, L. W. (1972). Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquine. J. natn. Cancer Inst. 48, 4125–1430.Google Scholar
Wattenberg, L. W. (1973). Inhibition of chemical carcinogen-induced pulmonary neoplasia by butylated hydroxanisole. J. natn. Cancer Inst. 50, 1541.CrossRefGoogle Scholar