Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-30T23:07:18.335Z Has data issue: false hasContentIssue false
  • English
  • Français

Application of voxel phantoms to study the influence of the heterogeneous distribution of actinides in lungs on in vivo counting using animal experiments

Published online by Cambridge University Press:  28 February 2007

S. Lamart ,
N. Pierrat ,
S. Rateau ,
E. Rouit ,
L. de Carlan ,
N. Dudoignon ,
M. Bottlaender ,
A. van der Meeren  and
D. Franck
S. Lamart
Affiliation:
IRSN, Laboratoire d’Évaluation de la Dose Interne, DRPH/SDI/LEDI, B.P. 17, 92262 Fontenay-aux-Roses, France
N. Pierrat
Affiliation:
IRSN, Laboratoire d’Évaluation de la Dose Interne, DRPH/SDI/LEDI, B.P. 17, 92262 Fontenay-aux-Roses, France
S. Rateau
Affiliation:
CEA, Laboratoire de Radiotoxicologie, DSV/DRR/SRCA/LRT, B.P. 12, 91680 Bruyères-le-Châtel, France
E. Rouit
Affiliation:
CEA, Laboratoire de Radiotoxicologie, DSV/DRR/SRCA/LRT, B.P. 12, 91680 Bruyères-le-Châtel, France
L. de Carlan
Affiliation:
IRSN, Laboratoire d’Évaluation de la Dose Interne, DRPH/SDI/LEDI, B.P. 17, 92262 Fontenay-aux-Roses, France
N. Dudoignon
Affiliation:
IRSN, Laboratoire de Radiopathologie, DRPH/SRBE/LRPAT, B.P. 17, 92262 Fontenay-aux-Roses, France
M. Bottlaender
Affiliation:
CEA, Service Hospitalier Frédéric Joliot, 4, place du général Leclerc, 91400 Orsay, France
A. van der Meeren
Affiliation:
CEA, Laboratoire de Radiotoxicologie, DSV/DRR/SRCA/LRT, B.P. 12, 91680 Bruyères-le-Châtel, France
D. Franck
Affiliation:
IRSN, Laboratoire d’Évaluation de la Dose Interne, DRPH/SDI/LEDI, B.P. 17, 92262 Fontenay-aux-Roses, France
Get access

Abstract

As part of the improvement of calibration techniques for in vivo counting, the Laboratory of Internal Dose Assessment of IRSN has developed a computer tool, “OEDIPE”, to model internal contamination in voxel phantoms, to simulate in vivo counting and to calculate internal dose. This software was used to model the real distribution of activity in the lungs of a baboon analyzed in the Laboratory of Radiotoxicology of CEA. This experiment provided the opportunity to study the influence of the heterogeneity of lung retention on the in vivo counting and to quantify its effect on the assessment of activity by comparison with a simulated homogeneous retention of the same total activity. The results show that the numerical simulation can be a relevant tool to reveal the heterogeneity of lung retention, allowing a determination of calibration factors adapted to heterogeneous contaminations that would be impossible by standard calibration with physical anthropomorphic phantoms.

Keywords

Lung countingMonte Carlo methodheterogeneous contamination modelanimal experiment
Type
Research Article
Information
Radioprotection , Volume 42 , Issue 1 , January 2007 , pp. 75 - 86
Copyright
© EDP Sciences, 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aubineau-Laniece, I., de Carlan, L., Clairand, I., Lemosquet, A., Chiavassa, S., Pierrat, N., Bardies, M., Franck, D. (2005a) Current developments at IRSN on computational tools dedicated to assessing doses for both internal and external exposure, Radiat. Prot. Dosim. 115, 522-529. CrossRef
Aubineau-Laniece I., de Carlan L., Pierrat N., Franck D., Chiavassa S., Bardies M. (2005b) Application of voxel phantoms for internal dosimetry at IRSN using a dedicated computational tool. In: Monte Carlo 2005 Topical Meeting, Chattanooga, TN.
Borisov, N., Franck, D., de Carlan, L., Laval, L. (2002) A new graphical user interface for fast construction of computation phantoms and MCNP calculations: application to calibration of in vivo measurement systems, Health Phys. 83, 272-279. CrossRef
Borisov N., Franck D., De Carlan L., Pierrat N., Kochetkov O., Yatsenko V. (2005) A new facility for MCNP application in whole body counting and internal dosimetry. In: Monte Carlo 2005 Topical Meeting, Chattanooga, TN.
Briesmeister J.F. (2000) MCNPTM – A general Monte-Carlo N-Particle transport code, version 4c, LANL memorandom, Los Alamos National Laboratory, LA-13709-M.
de Carlan L. (2004) Potential of new imaging and calculation techniques for the activity and dose assessment in case of localized contamination. In: IRPA 2004, Madrid.
de Carlan, L., Roch, P., Blanchardon, E., Franck, D. (2005) New method of voxel phantom creation: application for whole-body counting calibration and perspectives in individual internal dose assessment, Radiat. Prot. Dosim. 116, 160-164. CrossRef
Franck, D., Laval, L., Borissov, N., Guillierme, P., Bordy, J.M. (2001) Development of voxelised phantoms using MCNP Monte Carlo code: Application to in vivo measurement, Radioprotection 36, 77-86. CrossRef
Hickman D.P., Firpo M. (1997) Magnetic resonance image phantom program, Lawrence Livermore National Laboratory, Livermore, CA.
Hughes H.G., Prael R.E., Little R.C. (1997) MCNPX the LAHET/MCNP Code Merger, XTM-RN(U), 97-012.
ICRU (1989) Report 44, Tissue Substitutes in Radiation Dosimetry and Measurement, Bethesda.
Ishikawa, T., Uchiyama, M. (1997) Calculation of Counting Efficiency for 137Cs Using Voxel Phantoms with Lungs and a Skeleton, Radiat. Prot. Dosim. 69, 199-204. CrossRef
Lataillade, G., Verry, M., Rateau, G., Metivier, H., Masse, R. (1995) Translocation of plutonium from rat and monkey lung after inhalation of industrial plutonium oxide and mixed uranium and plutonium oxide, Intern. J. Rad. Biol. 67, 373-380. CrossRef
Mallett, M.W., Hickman, D.P., Kruchten, D.A., Poston, J.W. Jr. (1995) Development of a method for calibrating in vivo measurement systems using magnetic resonance imaging and Monte Carlo computations, Health Phys. 68, 773-785. CrossRef
Pierrat, N., De Carlan, L., Cavadore, D., Franck, D. (2005) Application of monte carlo calculation for the virtual calibration of a low-energy in vivo counting system, IEEE Trans. Nucl. Sci. 52, 1353-1358. CrossRef
Prot N. (1994) Anatomie systématique et topographique de la cavité thoracique du macaque cynomolgus, Thèse vétérinaire, Université Claude Bernard (Ecole Vétérinaire), Lyon.