Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-10T12:46:39.122Z Has data issue: false hasContentIssue false
  • English
  • Français

Le Flt3-ligand plasmatique, un bio-indicateur pronostique de l'atteinte radio-induite à la moelle osseuse

Published online by Cambridge University Press:  17 June 2005

J.-M. Bertho ,
J. Frick ,
C. Demarquay ,
J. Ph. Laporte ,
J. Aigueperse ,
N.-C. Gorin  and
P. Gourmelon
J.-M. Bertho
Affiliation:
Laboratoire de Radio-hématologie, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France. Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France.
J. Frick
Affiliation:
Laboratoire de Radio-hématologie, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France. Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France.
C. Demarquay
Affiliation:
Laboratoire de Radio-hématologie, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France. Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France.
J. Ph. Laporte
Affiliation:
Service des maladies du sang, Hôpital St. Antoine, Paris, France.
J. Aigueperse
Affiliation:
Section autonome de radiologie appliquée à la médecine, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France.
N.-C. Gorin
Affiliation:
Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France. Service des maladies du sang, Hôpital St. Antoine, Paris, France.
P. Gourmelon
Affiliation:
Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France. Département de protection de la santé de l'Homme et de dosimétrie, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France.
Get access

Abstract

Plasma Flt3-ligand as a prognostic bio-indicator of radiation-induced bone marrow damage.Following an accidental irradiation, the choice between different therapeutic strategies mainly depends upon the estimated radiation-induced bone marrow damage. It was shown recently that the serum concentration of Flt3-ligand (FL), a cytokine mainly acting on immature haemopoietic cells, is highly elevated in either acquired or induced bone marrow aplasia. This suggested to us that FL measurement could be used as a bio-indicator of radiation-induced bone marrow damage. In order to verify this hypothesis, studies were conducted in a non human primate model as well as in humans undergoing radio and/or chemotherapy. Results showed that the increase in FL concentration on day 5 after irradiation is predictive of the evolution of the haemopoietic syndrome. Similar results were obtained in humans. Overall these results suggested that FL measurement could be used as a reliable bio-indicator of radiation-induced bone marrow damage in accidental irradiation situations.

Keywords

biological indicatorshaematopoietic systembone marrowexposure, acuteaccident
Type
Research Article
Information
Radioprotection , Volume 36 , Issue 3 , July 2001 , pp. 303 - 315
Copyright
© EDP Sciences, 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)