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Preclinical Alzheimer's disease

Published online by Cambridge University Press:  20 March 2014

P Gil-Gregorio  and
R Yubero-Pancorbo
P Gil-Gregorio
Affiliation:
Memory Unit, Geriatric Department, Hospital Clinico San Carlos, Madrid, Spain
R Yubero-Pancorbo*
Affiliation:
Memory Unit, Geriatric Department, Hospital Clinico San Carlos, Madrid, Spain
*
Address for correspondence: Raquel Yubero, Hospital Clínico San Carlos, Servicio de Geriatría, c/Profesor Martín Lagos, s/n 28040, Madrid, Spain. Email: raquel_yubero@hotmail.com
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Summary

Recently, diagnostic criteria for preclinical Alzheimer's disease have been proposed. These describe and define three stages of disease. Stage I is focused on asymptomatic cerebral amyloidosis. Stage II includes evidence of synaptic dysfunction and/or early degeneration. Finally, stage III of the disease is characterized by the beginning of cognitive decline.

Keywords

Alzheimer’s diseasepreclinical stagesamyloidosisneurodegenerationcognition
Type
Review Article
Information
Reviews in Clinical Gerontology , Volume 24 , Issue 2 , May 2014 , pp. 117 - 121
Copyright
Copyright © Cambridge University Press 2014 

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