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Principles of altered drug handling in the elderly

Published online by Cambridge University Press:  17 November 2008

John G Kelly  and
Kevin O'Malley
John G Kelly
Affiliation:
Royal College of Surgeons in Ireland, Dublin, Eire
Kevin O'Malley*
Affiliation:
Royal College of Surgeons in Ireland, Dublin, Eire
*
John G Kelly, Senior Lecturer, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Eire.
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Abstract

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Type
Biological gerontology
Information
Reviews in Clinical Gerontology , Volume 2 , Issue 1 , February 1992 , pp. 11 - 19
Copyright
Copyright © Cambridge University Press 1992

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References

1Williamson, J, Chopin, JM.Adverse reactions to prescribed drugs in the elderly. Age Ageing 1980; 9: 73–80.CrossRefGoogle ScholarPubMed
2Nolan, L, O'malley, K.Prescribing for the elderly. Part 1. Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 1988; 36: 142–49.CrossRefGoogle Scholar
3Nolan, L, O'malley, K.Prescribing for the elderly. Part II. Prescribing patterns: differences due to age. J Am Geriatr Soc 1988; 36: 245–54.CrossRefGoogle ScholarPubMed
4Kellaway, GSM, McCrae, E.Intensive monitoring for adverse drug effects in patients discharged from acute medical wards. N Z Med J 1973; 78: 525–28.Google ScholarPubMed
5O'malley, K, Laher, M, Cusack, B, Kelly, JG. Clinical pharmacology and the elderly patient. In: Denham, MJ ed. The treatment of medical problems in the elderly. Lancaster: MTP Press, 1980: 1–33.Google Scholar
6Castleden, CM, Volans, CN, Raymond, K.The effect of aging on drug absorption from the gut. Age Ageing 1977; 6: 138–43.CrossRefGoogle ScholarPubMed
7Salem, SAM, Stevenson, IH.Absorption kinetics of aspirin and quinine in elderly subjects. Br J Clin Pharmacol 1977; 4: 397.CrossRefGoogle ScholarPubMed
8Cusack, B, Morgan, J, Kelly, JG, Larvan, J, Noel, J, O'malley, K.Digoxin in the elderly: pharmacokinetic consequences of old age. Clin Pharmacol Ther 1979; 25: 772–76.CrossRefGoogle ScholarPubMed
9Nation, RL, Triggs, EJ, Selig, M.Lignocaine kinetics in cardiac patients and aged subjects. Br J Clin Pharmacol 1977; 4: 439–48.CrossRefGoogle ScholarPubMed
10Kelly, JG, O'malley, K. Drug-protein binding in old age. In: Reidenberg, MM, Erill, S eds. Drug-protein binding. New York: Praeger, 1986: 163–71.Google Scholar
11Wallace, SM, Verbeeck, RV.Plasma protein binding of drugs in the elderly. Clin Pharmacokinet 1987; 12: 41–72.CrossRefGoogle ScholarPubMed
12Cusack, B, O'malley, K, Lavan, J, Noel, J, Kelly, JG.Protein binding and disposition of lignocaine in the elderly. Eur J Clin Pharmacol 1985; 29: 323–29.CrossRefGoogle ScholarPubMed
13Durnas, C, Loi, CM, Cusack, BJ.Hepatic drug metabolism and aging. Clin Pharmacokinet 1990; 359–89.CrossRefGoogle ScholarPubMed
14Woodhouse, KW, James, OFJ.Hepatic drug metabolism and aging. Br Med Bull 1990; 46: 22–35.CrossRefGoogle Scholar
15Boyd, E.Normal variability in weight of the adult human liver and spleen. Arch Pathol 1933; 16: 350–72.Google Scholar
16Bach, B, Molholm-Hansen, J, Kampmann, JP, Rasmussen, SN, Skorsted, L.Disposition of antipyrine and phenytoin correlated with age and liver volume in man. Clin Pharmacokinet 1981; 6: 389–96.CrossRefGoogle ScholarPubMed
17Wynne, HA, Cope, LH, Mutch, E, Rawlins, MD, Woodhouse, KN.The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology 1989; 9: 297–301.CrossRefGoogle ScholarPubMed
18Wynne, H, Mutch, E, James, OFW, Wright, IP, Rawlins, M, Woodhouse, KW.The effect of age upon the affinity of microsomal monooxygenase enzymes for subtrate in human liver. Age Ageing 1988; 17: 401–405.CrossRefGoogle Scholar
19Woodhouse, KW, Wynne, HA.Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly. Clin Pharmacokinet 1988; 15: 287–94.CrossRefGoogle ScholarPubMed
20Wilkinson, GR, Shand, DG.A physiological approach to hepatic drug metabolism. Clin Pharmacol Ther 1975; 18: 377–90.CrossRefGoogle Scholar
21O'malley, K, Crooks, J, Duke, E, Stevenson, IH.Effects of age and sex on drug metabolism. Br Med J 1971; 3: 607–609.CrossRefGoogle ScholarPubMed
22Vestal, RE, Norris, AH, Tobin, JD, Shock, NW.Antipyrine metabolism in man: influence of age, alcohol, caffeine and smoking. Clin Pharmacol Ther 1975; 18: 452–32.CrossRefGoogle ScholarPubMed
23Cusack, B, Kelly, JG, Lavan, J, Noel, J, O'malley, K.Theophylline kinetics in relation to age: the importance of smoking. Br J Clin Pharmacol 1980; 10: 109–14.CrossRefGoogle ScholarPubMed
24Anderson, KE.Influences of diet and nutrition on clinical pharmacokinetics. Clin Pharmacokinet 1988; 14: 325–46.CrossRefGoogle ScholarPubMed
25Davies, DF, Shock, NW.Age changes in glomerular filtration rate, effective renal plasma flow and tubular excretary capacity in adult males. J Clin Invest 1950; 29: 496–501.CrossRefGoogle Scholar
26O'malley, K, Doherty, JR, Kelly, JG.Adrenoceptor status and cardiovascular function in aging. J Hypertension 1988; 6 (suppl 1): S59–62.Google Scholar
27Vestal, RE, Wood, AJJ, Shand, DG.Reduced beta adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther 1979; 26: 181–86.CrossRefGoogle ScholarPubMed
28Stessman, J, Eliakim, R, Kalm, K, Ebstein, RP.The effect of age on salbutamol-induced plasma cyclic AMP rise in man: evidence for an age-associated deterioration in beta receptor-adenylate cyclase function. J Gerontol 1984; 39: 667–72.CrossRefGoogle Scholar
29Dillon, N, Chung, S, Kelly, JG.Age and beta adrenoceptor function. Clin Pharmacol Ther 1980; 27: 769–72.CrossRefGoogle Scholar
30Doyle, VM, O'malley, K, Kelly, JG.Human lymphocyte beta adrenoceptor density in relation to age and hypertension. J Cardiovasc Pharmacol 1982; 4: 738–40.CrossRefGoogle Scholar
31Docherty, JR.Aging and the cardiovascular system. J Auton Pharmacol 1986; 6: 77–84.CrossRefGoogle ScholarPubMed
32Kelliher, GH, Conahan, ST.Changes in vagal activity and response to muscarinic receptor agonists with age. J Gerontol 1980; 45: 842–49.CrossRefGoogle Scholar
33McGarry, K, Laher, M, Fitzgerald, D, Morgan, J, O'brien, E, O'malley, K.Baroreflex function in elderly hypertensives. Hypertension 1983; 5: 763–66.CrossRefGoogle ScholarPubMed
34Gordon, M, Preiksaitis, HG.Drugs and the aging brain. Geriatrics 1988; 43: 69–78.Google ScholarPubMed
35Castleden, CM, George, CF, Marcer, D, Hallet, C.Increased sensitivity to nitrazepam in old age. Br Med J 1977; 1: 10–12.CrossRefGoogle ScholarPubMed
36Swift, CG.Pharmacodynamics: changes in homeostatic mechanisms, receptor and target organ sensitivity in the elderly. Br Med Bull 1990; 46: 36–52.CrossRefGoogle ScholarPubMed
37Craig, TJ, Van Natta, PA.Medication use and depressive symptoms. Ny State J Med 1982; 82: 1439–43.Google ScholarPubMed
38Salzman, C, Shader, RI.Depression in the elderly. II: possible drug etiologies: differential diagnostic criteria. J Am Geriatr Soc 1978; 26: 303–308.CrossRefGoogle ScholarPubMed
39Goff, DC, Jenike, MA.Treatment resistant depression in the elderly. J Am Geriatr Soc 1986; 34: 63–70.CrossRefGoogle ScholarPubMed