Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-11T07:09:13.791Z Has data issue: false hasContentIssue false

Stroke as a medical emergency in older people

Published online by Cambridge University Press:  18 October 2010

Davinia Ryan
Affiliation:
Acute Stroke Service & Mercers Institute for Successful Ageing, St James's Hospital, Dublin, Ireland
Joseph Harbison*
Affiliation:
Acute Stroke Service & Mercers Institute for Successful Ageing, St James's Hospital, Dublin, Ireland
*
Address for correspondence: Dr Joseph Harbison, Acute Stroke Service & Mercers Institute for Successful Ageing, St James's Hospital, Dublin 8, Ireland. Email: joe.harbison@tcd.ie

Summary

In the last 20 years a realization has developed that acute stroke is a condition that benefits from early intensive investigation and treatment. Older people are historically less likely to receive such active management through a combination of limited evidence due to their exclusion from clinical trials and a level of ‘therapeutic nihilism’ regarding older subjects with severe, acute illness.

There is increasing evidence that many acute therapies, including thrombolysis, benefit older stroke patients. Older subjects may not achieve as good results as younger groups but differential benefits are often comparable when expected outcomes are considered. Risk of haemorrhagic complications with thrombolysis is not substantially increased and older subjects are now receiving this therapy despite a dearth of relevant trial data.

Intensive physiological monitoring and stroke unit care has been found to be of benefit to patients of all ages. Surgical options for intracerebral haemorrhage are limited, but there is little difference in the management of intracranial haemorrhage in older people. There is unlikely to be a benefit to surgical hemicraniectomy for cerebral infarction in those >60 years. In conclusion, active management for acute stroke in older people is frequently beneficial and age should not be a barrier to such care.

Type
Clinical geriatrics
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1World Health Organization. WHO Burden of Diseases and Injury (Dataset – 2004). Geneva, Switzerland: World Health Organization, 2009.Google Scholar
2Sudlow, CL, Warlow, CP. Comparable studies of the incidence of stroke and its pathological types: results from an international collaboration. International Stroke Incidence Collaboration. Stroke 1997; 28: 491–99.CrossRefGoogle ScholarPubMed
3Rothwell, PM, Coull, AJ, Giles, MF, Howard, SC, Silver, LE, Bull, LM, Gutnikov, SA, Edwards, P, Mant, D, Sackley, CM, Farmer, A, Sandercock, PA, Dennis, MS, Warlow, CP, Bamford, JM, Anslow, P; Oxford Vascular Study. Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet 2004; 363: 1925–33.CrossRefGoogle ScholarPubMed
4Lloyd-Jones, D, Adams, R, Carnethon, M, De Simone, G, Ferguson, TB, Flegal, K, Ford, E, Furie, K, Go, A, Greenlund, K, Haase, N, Hailpern, S, Ho, M, Howard, V, Kissela, B, Kittner, S, Lackland, D, Lisabeth, L, Marelli, A, McDermott, M, Meigs, J, Mozaffarian, D, Nichol, G, O'Donnell, C, Roger, V, Rosamond, W, Sacco, R, Sorlie, P, Stafford, R, Steinberger, J, Thom, T, Wasserthiel-Smoller, S, Wong, N, Wylie-Rosett, J, Hong, Y; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics – 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009; 119: 480–86.Google ScholarPubMed
5British Heart Foundation. Stroke statistics 2009. Available at: http://www.heartstats.org (accessed 11 July 2010).Google Scholar
6Biller, J, Love, BB. Nihilism and stroke therapy. Stroke 1991; 22: 1105–7.CrossRefGoogle ScholarPubMed
7Nakayama, H, Jørgensen, HS, Raaschou, HO, Olsen, TS. The influence of age on stroke outcome. The Copenhagen Stroke Study. Stroke 1994; 25: 808–13.Google Scholar
8Hier, DB, Edelstein, G. Deriving clinical prediction rules from stroke outcome research. Stroke 1991; 22; 1431–36.CrossRefGoogle ScholarPubMed
9Derex, L, Nighoghossian, N. Thrombolysis, stroke-unit admission and early rehabilitation in elderly patients. Nat Rev Neurol 2009; 5: 506–11.CrossRefGoogle ScholarPubMed
10Rudd, AG, Hoffman, A, Down, C, Pearson, M, Lowe, D. Access to stroke care in England, Wales and Northern Ireland: the effect of age, gender and weekend admission. Age Ageing 2007; 36: 247–55.CrossRefGoogle ScholarPubMed
11Fairhead, JF, Rothwell, PM. Underinvestigation and undertreatment of carotid disease in elderly patients with transient ischaemic attack and stroke: comparative population based study. BMJ 2006; 333: 525–27.CrossRefGoogle ScholarPubMed
12Rothwell, PM, Eliasziw, M, Gutnikov, SA, Warlow, CP, Barnett, HJ; Carotid Endarterectomy Trialists Collaboration. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 2004; 363: 915–24.CrossRefGoogle ScholarPubMed
13Gubitz, GJ, Sandercock, PA. Aspirin and heparin in acute ischaemic stroke in older patients. Drugs Aging 1999; 15: 2936.CrossRefGoogle ScholarPubMed
14Mant, J, Hobbs, FD, Fletcher, K, Roalfe, A, Fitzmaurice, D, Lip, GY, Murray, E; BAFTA investigators; Midland Research Practices Network (MidReC). Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet 2007; 370: 493503.CrossRefGoogle Scholar
15Beckett, NS, Peters, R, Fletcher, AE, Staessen, JA, Liu, L, Dumitrascu, D, Stoyanovsky, V, Antikainen, RL, Nikitin, Y, Anderson, C, Belhani, A, Forette, F, Rajkumar, C, Thijs, L, Banya, W, Bulpitt, CJ; HYVET Study Group. Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008; 358: 1887–98.Google Scholar
16Amarenco, P, Bogousslavsky, J, Callahan, A 3rd, Goldstein, LB, Hennerici, M, Rudolph, AE, Sillesen, H, Simunovic, L, Szarek, M, Welch, KM, Zivin, JA; Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006; 355: 549–59.Google ScholarPubMed
17Donnan, GA, Baron, JC, Ma, H, Davis, SM. Penumbral selection of patients for trials of acute stroke therapy. Lancet Neurol 2009; 8: 261–69.CrossRefGoogle ScholarPubMed
18Marchal, G, Rioux, P, Petit-Taboué, MC, Sette, G, Travère, JM, Le Poec, C, Courtheoux, P, Derlon, JM, Baron, JC. Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging. Arch Neurol 1992; 49: 1013–20.CrossRefGoogle ScholarPubMed
19Feldmann, E, Gordon, N, Brooks, JM, Brass, LM, Fayad, PB, Sawaya, KL, Nazareno, F, Levine, SR. Factors associated with early presentation of acute stroke. Stroke 1993; 24: 1805–10.CrossRefGoogle ScholarPubMed
20Kwan, J, Hand, P, Sandercock, P. A systematic review of barriers to delivery of thrombolysis for acute stroke. Age Ageing 2004; 33: 116–21.CrossRefGoogle ScholarPubMed
21Davalos, A, Castillo, J, Martinez-Vila, E. Delay in neurological attention and stroke outcome. Stroke 1995; 26: 2233–37.CrossRefGoogle ScholarPubMed
22Silvestrelli, G, Parnetti, L, Paciaroni, M, Caso, V, Corea, F, Vitali, R, Capocchi, G, Agnelli, G. Early admission to stroke unit influences clinical outcome. Eur J Neurol 2006; 13: 250–55.CrossRefGoogle ScholarPubMed
23Lichtman, JH, Watanabe, E, Allen, NB, Jones, SB, Dostal, J, Goldstein, LB. Hospital arrival time and intravenous t-PA use in US Academic Medical Centers, 2001–2004. Stroke 2009; 40: 3845–50.CrossRefGoogle ScholarPubMed
24Adams, HP Jr, del Zoppo, G, Alberts, MJ, Bhatt, DL, Brass, L, Furlan, A, Grubb, RL, Higashida, RT, Jauch, EC, Kidwell, C, Lyden, PD, Morgenstern, LB, Qureshi, AI, Rosenwasser, RH, Scott, PA, Wijdicks, EF; American Heart Association; American Stroke Association Stroke Council; Clinical Cardiology Council; Cardiovascular Radiology and Intervention Council; Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups. Stroke 2007; 38: 1655–711.CrossRefGoogle ScholarPubMed
25Harbison, J, Hossain, O, Jenkinson, D, Davis, J, Louw, SJ, Ford, GA. Diagnostic accuracy of stroke referrals from primary care, emergency room physicians, and ambulance staff using the face arm speech test. Stroke 2003; 34: 7176.CrossRefGoogle ScholarPubMed
26Chandratheva, A, Lasserson, DS, Geraghty, OC, Rothwell, PM; Oxford Vascular Study. Population-based study of behavior immediately after transient ischemic attack and minor stroke in 1000 consecutive patients: lessons for public education. Stroke 2010; 41: 1108–14.CrossRefGoogle ScholarPubMed
27Muangpaisan, W, Hinkle, JL, Westwood, M, Kennedy, J, Buchan, AM. Stroke in the very old: clinical presentations and outcomes. Age Ageing 2008; 37: 473–75.CrossRefGoogle ScholarPubMed
28Azzimondi, G, Bassein, L, Fiorani, L, Nonino, F, Montaguti, U, Celin, D, Re, G, D'Alessandro, R. Variables associated with hospital arrival time after stroke: effect of delay on the clinical efficiency of early treatment. Stroke 1997; 28: 537–42.Google Scholar
29Lacy, CR, Suh, DC, Bueno, M, Kostis, JB. Delay in presentation and evaluation for acute stroke: Stroke Time Registry for Outcomes Knowledge and Epidemiology (S.T.R.O.K.E.). Stroke 2001; 32: 6369.Google Scholar
30Wester, P, Rådberg, J, Lundgren, B, Peltonen, M. Factors associated with delayed admission to hospital and in-hospital delays in acute stroke and TIA: a prospective, multicenter study. Seek- Medical-Attention-in-Time Study Group. Stroke 1999; 30: 4048.CrossRefGoogle Scholar
31Nor, AM, Ford, GA. Misdiagnosis of stroke. Expert Rev Neurother 2007; 7: 9891001.CrossRefGoogle ScholarPubMed
32Hand, PJ, Kwan, J, Lindley, RI, Dennis, MS, Wardlaw, JM. Distinguishing between stroke and mimic at the bedside: the brain attack study. Stroke 2006; 37: 769–75.CrossRefGoogle ScholarPubMed
33Vroomen, PC, Buddingh, MK, Luijckx, GJ, De Keyser, J. The incidence of stroke mimics among stroke department admissions in relation to age group. J Stroke Cerebrovasc Dis 2008; 17: 418–22.CrossRefGoogle ScholarPubMed
34Winkler, DT, Fluri, F, Fuhr, P, Wetzel, SG, Lyrer, PA, Ruegg, S, Engelter, ST. Thrombolysis in stroke mimics: frequency, clinical characteristics, and outcome. Stroke 2009; 40: 1522–25.CrossRefGoogle ScholarPubMed
35Nor, AM, Davis, J, Sen, B, Shipsey, D, Louw, SJ, Dyker, AG, Davis, M, Ford, GA. The Recognition of Stroke in the Emergency Room (ROSIER) scale: development and validation of a stroke recognition instrument. Lancet Neurol 2005; 4: 727–34.CrossRefGoogle ScholarPubMed
36Vu, D, Lev, MH. Non-contrast CT in acute stroke. Semin Ultrasound CT MR 2005; 26: 380–86.CrossRefGoogle Scholar
37Vermeer, SE, Koudstaal, PJ, Oudkerk, M, Hofman, A, Breteler, MM. Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke 2002; 33: 2125.CrossRefGoogle ScholarPubMed
38Koton, S, Schwammenthal, Y, Merzeliak, O, Philips, T, Tsabari, R, Orion, D, Dichtiar, R, Tanne, D. Cerebral leukoaraiosis in patients with stroke or TIA: clinical correlates and 1-year outcome. Eur J Neurol 2009; 16: 218–25.Google Scholar
39Pexman, JH, Barber, PA, Hill, MD, Sevick, RJ, Demchuk, AM, Hudon, ME, Hu, WY, Buchan, AM. Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. AJNR 2001; 22: 1534–42.Google ScholarPubMed
40Demaerschalk, BM, Silver, B, Wong, E, Merino, JG, Tamayo, A, Hachinski, V. ASPECT scoring to estimate >1/3 middle cerebral artery territory infarction. Can J Neurol Sci 2006; 33: 200–4.CrossRefGoogle ScholarPubMed
41Puetz, V, Dzialowski, I, Hill, MD, Demchuk, AM. The Alberta Stroke Program Early CT Score in clinical practice: what have we learned? Int J Stroke 2009; 4: 354–64.CrossRefGoogle ScholarPubMed
42Schaefer, PW, Barak, ER, Kamalian, S, Gharai, LR, Schwamm, L, Gonzalez, RG, Lev, MH. Quantitative assessment of core/penumbra mismatch in acute stroke: CT and MR perfusion imaging are strongly correlated when sufficient brain volume is imaged. Stroke 2008; 39: 2986–92.CrossRefGoogle Scholar
43Köhrmann, M, Jüttler, E, Huttner, HB, Nowe, T, Schellinger, PD. Acute stroke imaging for thrombolytic therapy – an update. Cerebrovasc Dis 2007; 24: 161–69.CrossRefGoogle ScholarPubMed
44Hopyan, JJ, Gladstone, DJ, Mallia, G, Schiff, J, Fox, AJ, Symons, SP, Buck, BH, Black, SE, Aviv, RI. Renal safety of CT angiography and perfusion imaging in the emergency evaluation of acute stroke. AJNR 2008; 29: 1826–30.CrossRefGoogle ScholarPubMed
45Mehdiratta, M, Schlaug, G, Kumar, S, Caplan, LR, Selim, M. Reducing the delay in thrombolysis: is it necessary to await the results of renal function tests before computed tomography perfusion and angiography in patients with code stroke? J Stroke Cerebrovasc Dis 2008; 17: 273–75.Google Scholar
46Wardlaw, JM, Seymour, J, Cairns, J, Keir, S, Lewis, S, Sandercock, P. Immediate computed tomography scanning of acute stroke is cost-effective and improves quality of life. Stroke 2004; 35: 2477–83.CrossRefGoogle ScholarPubMed
47Wahlgren, N, Ahmed, N, Dávalos, A, Ford, GA, Grond, M, Hacke, W, Hennerici, MG, Kaste, M, Kuelkens, S, Larrue, V, Lees, KR, Roine, RO, Soinne, L, Toni, D, Vanhooren, G; SITS-MOST investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 2007; 369: 275–82.Google Scholar
48Todd, G, Kimber, TE, Ridding, MC, Semmler, JG. Reduced motor cortex plasticity following inhibitory rTMS in older adults. Clin Neurophysiol 2010; 121: 441–47.CrossRefGoogle ScholarPubMed
49Ergeletzis, D, Kevorkian, CG, Rintala, D. Rehabilitation of the older stroke patient: functional outcome and comparison with younger patients. Am J Phys Med Rehabil 2002; 81: 881–89.CrossRefGoogle ScholarPubMed
50Luk, JK, Cheung, RT, Ho, SL, Li, L. Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects. Cerebrovasc Dis 2006; 21: 229–34.CrossRefGoogle ScholarPubMed
51NINDS study group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333: 1581–87.CrossRefGoogle Scholar
52Steiner, T, Bluhmki, E, Kaste, M, Toni, D, Trouillas, P, von Kummer, R, Hacke, W. The ECASS 3-hour cohort: secondary analysis of ECASS data by time stratification. Cerebrovasc Dis 1998; 8: 198203.CrossRefGoogle ScholarPubMed
53Hacke, W, Kaste, M, Fieschi, C, von Kummer, R, Davalos, A, Meier, D, Larrue, V, Bluhmki, E, Davis, S, Donnan, G, Schneider, D, Diez-Tejedor, E, Trouillas, P. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998; 352: 1245–51.Google Scholar
54Hacke, W, Kaste, M, Bluhmki, E, Brozman, M, Dávalos, A, Guidetti, D, Larrue, V, Lees, KR, Medeghri, Z, Machnig, T, Schneider, D, von Kummer, R, Wahlgren, N, Toni, D; ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008; 359: 1317–29.CrossRefGoogle ScholarPubMed
55Meretoja, A, Putaala, J, Tatlisumak, T, Atula, S, Artto, V, Curtze, S, Häppölä, O, Lindsberg, PJ, Mustanoja, S, Piironen, K, Pitkäniemi, J, Rantanen, K, Sairanen, T, Salonen, O, Silvennoinen, H, Soinne, L, Strbian, D, Tiainen, M, Kaste, M. Off-label thrombolysis is not associated with poor outcome in patients with stroke. Stroke 2010; 41: 1450–58.CrossRefGoogle Scholar
56Sylaja, PN, Cote, R, Buchan, AM, Hill, MD. Canadian Alteplase for Stroke Effectiveness Study (CASES) Investigators. Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study. J Neurol Neurosurg Psychiatry 2006; 77: 826–29.CrossRefGoogle ScholarPubMed
57Mishra, NK, Ahmed, N, Andersen, G et al. Improved outcomes after thrombolysis amongst very elderly: a controlled comparison of the SITS international registry (SITS-ISTR) versus Virtual International Stroke Trials Archive (VISTA). Cerebrovascular Dis 2010; 29 (suppl 2): abstract 614.Google Scholar
58Whiteley, W, Lindley, R, Wardlaw, J, Sandercock, P; IST-3 Collaborative Group. Third international stroke trial. Int J Stroke 2006; 1: 172–76.CrossRefGoogle ScholarPubMed
59Meyers, PM, Schumacher, HC, Higashida, RT, Barnwell, SL, Creager, MA, Gupta, R, McDougall, CG, Pandey, DK, Sacks, D, Wechsler, LR; American Heart Association. Indications for the performance of intracranial endovascular neurointerventional procedures: a scientific statement from the American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Interdisciplinary Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. Circulation 2009; 119: 2235–49.CrossRefGoogle ScholarPubMed
60Kim, D, Ford, GA, Kidwell, CS, Starkman, S, Vinuela, F, Duckwiler, GR, Jahan, R, Saver, JL; UCLA Intra-Arterial Thrombolysis Investigators. Intra-arterial thrombolysis for acute stroke in patients 80 and older: a comparison of results in patients younger than 80 years. AJNR Am J Neuroradiol 2007; 28: 159–63.Google Scholar
61Hacke, W, Schwab, S, Horn, M, Spranger, M, DeGeorgia, M, von Kummer, R. ‘Malignant’ middle cerebral artery infarction: clinical course and prognostic signs. Arch Neurol 1996; 53: 309–15.CrossRefGoogle ScholarPubMed
62Gupta, R, Connolly, ES, Mayer, S, Elkind, MS. Hemicraniectomy for massive middle cerebral artery territory infarction: a systematic review. Stroke 2004; 35: 539–43.CrossRefGoogle ScholarPubMed
63Vahedi, K, Hofmeijer, J, Juettler, E, Vicaut, E, George, B, Algra, A, Amelink, GJ, Schmiedeck, P, Schwab, S, Rothwell, PM, Bousser, MG, Van Der Worp, HB, Hacke, W; DECIMAL, DESTINY, and HAMLET investigators. Early decompressive surgery in malignant middle cerebral artery infarction: pooled analysis of three randomized controlled trials. Lancet Neurol 2007; 6: 215–22.CrossRefGoogle Scholar
64Sacco, RL, Mayer, SA. Epidemiology of intracerebral hemorrhage. In Feldmann, E (ed), Intracerebral Hemorrhage. Armonk, NY: Futura Publishing Co, 1994; pp. 323.Google Scholar
65Broderick, J, Connolly, S, Feldmann, E, Hanley, D, Kase, C, Krieger, D, Mayberg, M, Morgenstern, L, Ogilvy, CS, Vespa, P, Zuccarello, M; American Heart Association; American Stroke Association Stroke Council; High Blood Pressure Research Council; Quality of Care and Outcomes in Research Interdisciplinary Working Group. Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/ American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke 2007; 38: 2001–23.CrossRefGoogle ScholarPubMed
66Anderson, CS, Huang, Y, Wang, JG, Arima, H, Neal, B, Peng, B, Heeley, E, Skulina, C, Parsons, MW, Kim, JS, Tao, QL, Li, YC, Jiang, JD, Tai, LW, Zhang, JL, Xu, E, Cheng, Y, Heritier, S, Morgenstern, LB, Chalmers, J; INTERACT Investigators. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a pilot randomised trial. Lancet Neurol 2008; 7: 391–99.CrossRefGoogle Scholar
67Mendelow, AD, Gregson, BA, Fernandes, HM, Murray, GD, Teasdale, GM, Hope, DT, Karimi, A, Shaw, MD, Barer, DH; STICH investigators. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet 2005; 365: 387–97.CrossRefGoogle Scholar
68Mendelow, AD, Unterberg, A. Surgical treatment of intracerebral haemorrhage. Curr Opin Crit Care 2007; 13: 169–74.CrossRefGoogle ScholarPubMed
69Qureshi, AI, Mendelow, AD, Hanley, DF. Intracerebral haemorrhage. Lancet 2009; 373: 1632–44.CrossRefGoogle ScholarPubMed
70Sudlow, CL, Warlow, CP. Comparable studies of the incidence of stroke and its pathological types: results from an international collaboration. Stroke 1997; 28: 4191–99.CrossRefGoogle ScholarPubMed
71Lanzino, G, Kassell, NF, Germanson, TP, Kongable, GL, Truskowski, LL, Torner, JC, Jane, JA. Age and outcome after aneurysmal subarachnoid hemorrhage: why do older patients fare worse? J Neurosurg 1996; 85: 410–18.CrossRefGoogle ScholarPubMed
72O'Sullivan, MG, Dorward, N, Whittle, IR, Steers, AJ, Miller, JD. Management and long-term outcome following subarachnoid hemorrhage and intracranial aneurysm surgery in elderly patients: an audit of 199 consecutive cases. Br J Neurosurg 1994; 8: 2330.CrossRefGoogle ScholarPubMed
73Sugita, M, Nukui, H, Kobayashi, C, Horikoshi, T, Yagishita, T. Surgical outcomes in elderly patients with aneurysmal subarachnoid hemorrhage. Int Congress Ser 2004; 1259: 169–75.Google Scholar
74de Rooij, NK, Linn, FH, Van Der Plas, JA, Algra, A, Rinkel, GJ. Incidence of subarachnoid hemorrhage: A systematic review with emphasis on region, age, gender and time trends. JNNP 2007; 78: 1365–72.Google Scholar
75Stapf, C, Khaw, AV, Sciacca, RR, Hofmeister, C, Schumacher, HC, Pile-Spellman, J, Mast, H, Mohr, JP, Hartmann, A. Effect of age on clinical and morphological characteristics in patients with brain arteriovenous malformation. Stroke 2003; 34: 2664–69.CrossRefGoogle ScholarPubMed
76Masud, H, Morris, RO. Epidemiology of falls. Age Ageing 2001; 30: 37.CrossRefGoogle ScholarPubMed
77Torn, M, Bollen, WL, Van Der Meer, FJ, Van Der Wall, EE, Rosendaal, FR. Risks of oral anticoagulant therapy with increasing age. Arch Intern Med 2005; 165: 1527–32.CrossRefGoogle ScholarPubMed
78Miller, JH, Wardlaw, JM, Lammie, GA. Intracerebral hemorrhage and cerebral amyloid angiopathy: CT features and pathological correlation. Clin Radiol 1999; 54: 422–29.CrossRefGoogle ScholarPubMed
79Fridriksson, SM, Hillman, J, Saveland, H, Brandt, L. Intracranial aneurysm surgery in the 8th and 9th decades of life: impact on population-based management outcome. Neurosurgery 1995; 37: 627–31.CrossRefGoogle ScholarPubMed
80Enblad, P, Persson, L. Impact on clinical outcome of secondary brain insults during the neurointensive care of patients with subarachnoid hemorrhage: a pilot study. JNNP 1997; 62: 512–16.Google Scholar
81Johansson, M, Cesarini, KG, Contant, CF, Persson, L, Enblad, P. Changes in intervention and outcome in elderly patients with subarachnoid hemorrhage. Stroke 2001; 32: 2845–49.Google Scholar
82European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008; 25: 457507.CrossRefGoogle Scholar
83Stroke Unit Trialists’ Collaboration. Organised in-patient (stroke unit) care for stroke. Cochrane Database Syst Rev 2007; 4: CD000197.Google Scholar
84Smith, EE, Hassan, KA, Fang, J, Selchen, D, Kapral, MK, Saposnik, G; On behalf of the Investigators of the Registry of the Canadian Stroke Network (RCSN) for the Stroke Outcome Research Canada (SORCan) Working Group. Do all ischemic stroke subtypes benefit from organized inpatient stroke care? Neurology 2010; 75: 456–62.Google Scholar
85Langhorne, P, Lewsey, JD, Jhund, PS, Gillies, M, Chalmers, JW, Redpath, A, Briggs, A, Walters, M, Capewell, S, McMurray, JJ, Macintyre, K. Estimating the impact of stroke unit care in a whole population: an epidemiological study using routine data. JNNP 2010 (epub 2 July).CrossRefGoogle Scholar
86Terént, A, Asplund, K, Farahmand, B, Henriksson, KM, Norrving, B, Stegmayr, B, Wester, PO, Asberg, KH, Asberg, S; Riks-Stroke Collaboration. Stroke unit care revisited: who benefits the most? A cohort study of 105,043 patients in Riks-Stroke, the Swedish Stroke Register. JNNP 2009; 80: 881–87.Google ScholarPubMed
87Saposnik, G, Kapral, MK, Coutts, SB, Fang, J, Demchuk, AM, Hill, MD; Investigators of the Registry of the Canadian Stroke Network (RCSN) for the Stroke Outcome Research Canada (SORCan) Working Group. Do all age groups benefit from organized inpatient stroke care? Stroke 2009; 40: 3321–27.CrossRefGoogle Scholar