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GU receptors of double helices mediate tRNA movement in the ribosome

Published online by Cambridge University Press:  20 August 2002

MATTHIEU G. GAGNON  and
SERGEY V. STEINBERG
MATTHIEU G. GAGNON
Affiliation:
Département de Biochimie, Université de Montréal, Montréal, Québec H3C 3J7, Canada
SERGEY V. STEINBERG
Affiliation:
Département de Biochimie, Université de Montréal, Montréal, Québec H3C 3J7, Canada
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Abstract

A new RNA structural motif consisting of two double helices closely packed via minor grooves is found in many places in the ribosome structure. The packing requires that a GU base pair in one helix be packed against a Watson–Crick pair in the other helix. Two such motifs mediate the interaction of the P- and E-tRNA with the large ribosomal subunit. Analysis of the particular positions of these two motifs in view of the available data on occupancy of tRNA-binding sites and structural changes in the ribosome during the elongation cycle suggests a distinct role for each motif in tRNA translocation.

Keywords

double helix packingGU base pairribosomal RNAribosomal translocationribosome structure
Type
Research Article
Information
RNA , Volume 8 , Issue 7 , July 2002 , pp. 873 - 877
Copyright
2002 RNA Society

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