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New insight into RNase P RNA structure from comparative analysis of the archaeal RNA

Published online by Cambridge University Press:  07 February 2001

J. KIRK HARRIS ,
ELIZABETH S. HAAS ,
DANIEL WILLIAMS ,
DANIEL N. FRANK  and
JAMES W. BROWN
J. KIRK HARRIS
Affiliation:
Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695, USA Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA
ELIZABETH S. HAAS
Affiliation:
Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695, USA
DANIEL WILLIAMS
Affiliation:
Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695, USA
DANIEL N. FRANK
Affiliation:
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA
JAMES W. BROWN
Affiliation:
Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695, USA
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Abstract

A detailed comparative analysis of archaeal RNase P RNA structure and a comparison of the resulting structural information with that of the bacterial RNA reveals that the archaeal RNase P RNAs are strikingly similar to those of Bacteria. The differences between the secondary structure models of archaeal and bacterial RNase P RNA have largely disappeared, and even variation in the sequence and structure of the RNAs are similar in extent and type. The structure of the cruciform (P7–11) has been reevaluated on the basis of a total of 321 bacterial and archaeal sequences, leading to a model for the structure of this region of the RNA that includes an extension to P11 that consistently organizes the cruciform and adjacent highly-conserved sequences.

Keywords

Archaeaarchaebacteriaribonuclease PribozymernpB
Type
Research Article
Information
RNA , Volume 7 , Issue 2 , February 2001 , pp. 220 - 232
Copyright
2001 RNA Society

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