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Studies of the human ascending pain pathways

Published online by Cambridge University Press:  11 October 2005

NIRIT WEISS ,
H. CHRISTOPHER LAWSON ,
JOEL D. GREENSPAN ,
SHINJI OHARA  and
FREDERICK A. LENZ
NIRIT WEISS
Affiliation:
Department of Neurosurgery, Mount Sinai Medical Center, New York, NY
H. CHRISTOPHER LAWSON
Affiliation:
Department of Neurosurgery, Johns Hopkins University, Baltimore
JOEL D. GREENSPAN
Affiliation:
Department of Anesthesiology, University of Maryland, Baltimore Department of OCBS, Dental School, University of Maryland, Baltimore
SHINJI OHARA
Affiliation:
Department of Neurosurgery, Johns Hopkins University, Baltimore
FREDERICK A. LENZ
Affiliation:
Department of Neurosurgery, Johns Hopkins University, Baltimore
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Abstract

Chronic pain is an immense, unsolved, clinical problem. Current approaches to this condition are limited by uncertainty about mechanisms of acute and chronic pain in humans. Although much progress has been made toward understanding peripheral neural mechanisms of human nociception, we have a poor understanding of CNS pain mechanisms. Here, we review the anatomy and physiology of the ascending spinal pathways and supraspinal centers with pain-related activity. This review focuses on the primate nervous systems because there are significant differences between pain transmission in primates and other species such as cats and rats.

Keywords

Neurophysiologyspinal cordthalamuscortexsingle-neuron recordings
Type
Review Article
Information
Thalamus & Related Systems , Volume 3 , Issue 1 , March 2005 , pp. 71 - 86
Copyright
© 2005 Cambridge University Press

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