Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-10T22:08:29.394Z Has data issue: false hasContentIssue false
  • English
  • Français

Thalamocortical dysrhythmia I. Functional and imaging aspects

Published online by Cambridge University Press:  12 April 2006

R. Llinás ,
U. Ribary ,
D. Jeanmonod ,
R. Cancro ,
E. Kronberg ,
J. Schulman ,
M. Zonenshayn ,
M. Magnin ,
A. Morel  and
M. Siegmund
R. Llinás
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue MSB-442, New York, NY 10016, USA
U. Ribary
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue MSB-442, New York, NY 10016, USA
D. Jeanmonod
Affiliation:
Neurochirurgische Klinik, Universitatsspital Zurich, Zurich, Switzerland
R. Cancro
Affiliation:
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
E. Kronberg
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue MSB-442, New York, NY 10016, USA
J. Schulman
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue MSB-442, New York, NY 10016, USA
M. Zonenshayn
Affiliation:
Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue MSB-442, New York, NY 10016, USA
M. Magnin
Affiliation:
Neurochirurgische Klinik, Universitatsspital Zurich, Zurich, Switzerland
A. Morel
Affiliation:
Neurochirurgische Klinik, Universitatsspital Zurich, Zurich, Switzerland
M. Siegmund
Affiliation:
Neurochirurgische Klinik, Universitatsspital Zurich, Zurich, Switzerland
Get access Rights & Permissions [Opens in a new window]

Abstract

Thalamic and cortical neurons are richly and reciprocally interconnected and support recurrent functional loops in the intact brain, but the role of this circuitry is still poorly understood. Here, we present evidence—from cellular and from functional neuroimaging in control and clinical domains—that thalamocortical resonance is not only a prerequisite for normal cognition, but that its perturbation, in a dynamic sense (e.g. a dysrhythmia) can underlie a variety of neurological and psychiatric disorders.

Keywords

Corticothalamic re-entryIntrinsic propertiesBurst firingMEGEdge effect
Type
Research Article
Information
Thalamus & Related Systems , Volume 1 , Issue 3 , November 2001 , pp. 237 - 244
Copyright
2001 Elsevier Science Ltd

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)