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Characteristics of Outcome in Schizophrenia at 13 Years

Published online by Cambridge University Press:  02 January 2018

Peter Mason ,
Glynn Harrison ,
Cristine Glazebrook ,
Ian Medley ,
Tim Dalkin  and
Tim Croudace
Peter Mason*
Affiliation:
Department of Psychiatry, University Hospital, Nottingham
Glynn Harrison
Affiliation:
Department of Psychiatry, University Hospital, Nottingham
Cristine Glazebrook
Affiliation:
Department of Psychiatry, University Hospital, Nottingham
Ian Medley
Affiliation:
Mandala Centre, Nottingham
Tim Dalkin
Affiliation:
Department of Psychiatry, University Hospital, Nottingham
Tim Croudace
Affiliation:
Department of Psychology, University of Nottingham
*
Dr Mason, Department of Psychiatry, University Hospital, Nottingham NG7 2UH
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Abstract

Background

This paper describes the 13-year outcome of an epidemiologically defined and representative cohort of patients selected when they were experiencing their first episode of schizophrenia.

Method

In a 13-year follow-up study of a cohort identified in Nottingham in 1978–80, the outcome (symptoms, disability, residence and treatment) was assessed using standardised instruments.

Results

Four of the original 67 patients with ICD–9 schizophrenia were lost to follow-up and five were dead: 52% were without psychotic symptoms in the last two years of follow-up, 52% were without negative symptoms and 55% showed good/fair social functioning. However, only 17% were alive at follow-up, without symptoms and disability, and receiving no treatment.

Conclusions

The findings reported are similar to those of other long-term follow-up studies of schizophrenia and also to 5-year follow-up studies. Kraepelin's emphasis on the longitudinal implications of a diagnosis of schizophrenia are supported, but may be over-pessimistic.

Type
Papers
Information
The British Journal of Psychiatry , Volume 167 , Issue 5 , November 1995 , pp. 596 - 603
Copyright
Copyright © 1995 The Royal College of Psychiatrists 

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References

Andreasen, N. C. (1982) Negative symptoms in schizophrenia, definition and reliability. Archives of General Psychiatry, 39, 784–788.Google Scholar
Bland, R. C., Parker, J. H. & Orn, H. (1976) Prognosis in schizophrenia. A ten year follow-up of first admissions. Archives of General Psychiatry, 33, 949–954.Google Scholar
Bleuler, M. (1978) The Schizophrenic Disorders: Long-term Patient and Family Studies (trans. Clemens, S. M.). New Haven, CT: Yale University Press.Google Scholar
Carone, B. J., Harrow, M. & Westermeyer, J. F. (1991) Posthospital course and outcome in schizophrenia. Archives of General Psychiatry, 48, 247–253.Google Scholar
Ciompi, L. (1980) Catamnestic long-term study on the course of life and aging of schizophrenics. Schizophrenia Bulletin, 6, 606–618.Google Scholar
Cooper, J. E., Goodhead, D., Craig, T., et al (1987) The incidence of schizophrenia in Nottingham. British Journal of Psychiatry, 151, 619–626.CrossRefGoogle ScholarPubMed
De Jong, A., Giel, R., Slooff, C. J., et al (1985) Social disability and outcome in schizophrenic patients. British Journal of Psychiatry, 147, 631–636.Google Scholar
Endicott, J., Spitzer, R. L., Fleiss, J. L., et al (1976) The Global Assessment Scale. A procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry, 33, 766–771.CrossRefGoogle Scholar
Fenton, W. S. & McGlashan, T. H. (1991) Natural history of schizophrenia subtypes. II. Positive and negative symptoms and long-term course. Archives of General Psychiatry, 48, 978–986.CrossRefGoogle ScholarPubMed
Harrison, G. & Mason, P. (1993) Schizophrenia – falling incidence and better outcome? British Journal of Psychiatry, 163, 535–541.Google Scholar
Harrison, G. & Mason, P. Glazebrook, C., et al (1994) Residence of an incident cohort of psychotic patiente after 13 years of follow-up. British Medical Journal, 308, 813–816.Google Scholar
Harrow, M., Yonan, C. A., Sands, J. R., et al (1994) Depression in schizophrenia: are neuroleptics, akinesia, or anhedonia involved? Schizophrenia Bulletin, 20, 327–338.Google Scholar
Hegarty, J. D., Baldbssarini, R. J., Tohen, M., et al (1994) One hundred years of schizophrenia: a meta-analysis of the outcome literature. American Journal of Psychiatry, 151, 1409–1416.Google Scholar
Huber, G., Gross, G., Schuttler, R., et al (1980) Longitudinal studies of schizophrenic patients. Schizophrenia Bulletin, 6, 592–605.CrossRefGoogle ScholarPubMed
Jablensky, A. (1978) Psychological Impairments Rating Schedule. Geneva: WHO.Google Scholar
Jablensky, A. Sartorius, N., Ernberg, E., et al (1992) Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization Ten-Country Study. Psychological Medicine, Monograph Supplement 20. Cambridge: Cambridge University Press.Google Scholar
Johnstone, E. C., Frith, C. D., Crow, T. J., et al (1992) The Northwick Park ‘Functional’ Psychosis Study: diagnosis and outcome. Psychological Medicine, 22, 331–346.Google Scholar
Kraepelin, E. (1919) Dementia Praecox (trans. ed. Barclay, R. M.). Edinburgh: E. S. Livingstone.Google Scholar
Krawiecka, M., Goldberg, D. & Vaughn, M. (1977) A standardised psychiatric assessment scale for rating psychotic patients. Acta Psychiatrica Scandinavica, 55, 299–308.Google Scholar
Leary, J., Johnstone, E. C. & Owens, D. G. C. (1991) Disabilities and circumstances of schizophrenic patients – a follow-up study. II. Social outcome. British Journal of Psychiatry, 159 (suppl. 13), 13–20.Google Scholar
Leff, J., Sartorius, N., Jablensky, A., et al (1992) The International Pilot Study of Schizophrenia: five-year follow-up findings. Psychological Medicine, 22, 131–145.Google Scholar
MacMillan, J. F., Crow, T. J., Johnson, A. L., et al (1986) The Northwick Park Study of first episodes of schizophrenia. III. Short-term outcome in trial entrants and trial eligible patients. British Journal of Psychiatry, 136, 384–395.Google Scholar
Mueser, K. T., Yarnold, P. R., Levinson, D. F., et al (1990) Prevalence of substance abuse in schizophrenia: demographic and clinical correlates. Schizophrenia Bulletin, 16, 31–56.Google Scholar
Prudo, R. & Blum, H. M. (1987) Five-year outcome and prognosis in schizophrenia: A report from the London Field Research Centre of the International Pilot Study of Schizophrenia. British Journal of Psychiatry, 150, 345–354.CrossRefGoogle ScholarPubMed
Sartorius, N., Gulbinat, W., Harrison, G., et al (1995) Long-term follow-up study of schizophrenia in ten countries. Journal of Social Psychiatry and Epidemiology, (in press).Google Scholar
Schubart, C., Krumm, B., Biehl, H., et al (1986) Measurement of social disability in a schizophrenic patient group. Social Psychiatry, 21, 1–9.CrossRefGoogle Scholar
Scottish Schizophrenia Research Group (1989) The Scottish first episode schizophrenia study. VII. Two-year follow-up. Acta Psychiatrica Scandinavica, 80, 597–602.CrossRefGoogle Scholar
Scottish Schizophrenia Research Group (1992) The Scottish first episode schizophrenia study. VIII. Five-year follow-up: clinical and psychosocial findings. British Journal of Psychiatry, 161, 496–500.CrossRefGoogle Scholar
Shepherd, M., Watt, D., Falloon, I., et al (1989) The natural history of schizophrenia: a five-year follow-up study of outcome and prediction in a representative sample of schizophrenics. Psychological Medicine Monograph Supplement 15. Cambridge: Cambridge University Press.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press.Google Scholar
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