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Depression in Later Life

A Comparison of Symptoms and Risk Factors in Early and Late Onset Cases

Published online by Cambridge University Press:  02 January 2018

R. C. Baldwin  and
Barbara Tomenson
R. C. Baldwin*
Affiliation:
Manchester Royal Infirmary
Barbara Tomenson
Affiliation:
University Department of Psychiatry, Manchester
*
Dr Baldwin, York House, Manchester Royal Infirmary, Oxford Road, Manchester M13 9BX. Fax: 0161 276 5317
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Abstract

Background

Depression in later life is often thought to differ from that at other times of adulthood. The evidence for this is controversial but is important to any proposed organic model of depression in the elderly. Here, early- and late-onset depressions in later life are compared.

Method

Fifty-seven depressed patients with a mean age of 74 were studied, 21 with an early onset (aged 59 or less) and 36 with a late onset. All were suffering from major depression according to DSM–III–R. The measures at entry included severity and symptoms, cognitive function, antecedent life events, physical health and vascular risk factors and/or vascular disease. We also recorded any family history of mood disorders, as well as the course of illness.

Results

The anxiety item scores of the Hamilton Depression Rating Scale were significantly higher in those with an early onset, but otherwise symptoms differed little. Heritability was greater in the early-onset group. There was a striking association of vascular disease and/or risk with late-onset patients.

Conclusions

Vascular disease is associated with late-onset depression. This is consistent with the hypothesis that depression in later life is a more ‘biological’ disorder.

Type
Papers
Information
The British Journal of Psychiatry , Volume 167 , Issue 5 , November 1995 , pp. 649 - 652
Copyright
Copyright © 1995 The Royal College of Psychiatrists 

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