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Effect of ADP on PGE1 Formation in Blood Platelets from Patients with Depression, Mania and Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Y. H. Abdulla  and
K. Hamadah
Y. H. Abdulla
Affiliation:
Department of Pathology, Guy's Hospital Medical School, London, SE1 9RT
K. Hamadah
Affiliation:
Tooting Bec Hospital, London, SW17 8BL
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Summary

Adenosine diphosphate (ADP) stimulates the synthesis of prostaglandin E1 (PGE1) in lysed platelets from normal subjects, patients with affective illness but not in platelets from cases of schizophrenia. The stimulation is concentration-dependent and follows a curve which is mildly sigmoid in the normal, markedly sigmoid in depression and hyperbolic in mania.

Type
Papers
Information
The British Journal of Psychiatry , Volume 127 , Issue 6 , December 1975 , pp. 591 - 595
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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