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Efficacy and Side Effects of Nitrazepam and Thioridazine as Sleeping Aids in Psychogeriatric In-patients

Published online by Cambridge University Press:  29 January 2018

Markku Linnoila  and
Matti Viukari
Markku Linnoila*
Affiliation:
Finnish Academy, Department of Pharmacology, University of Helsinki, Helsinki, Finland
Matti Viukari
Affiliation:
Koskela Geriatric Hospital, Helsinki, Finland
*
Address for correspondence: Markku Linnoila, M.D., Box 2921, Duke University Medical Center, Durham, North Carolina 27710, USA
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Summary

The efficacy and side effects of 10 mg of nitrazepam and 25 mg of thioridazine as sleeping aids were measured in 20 psychogeriatric in-patients during the 14th night and morning of drug administration. The trial used a double blind, cross-over design. The effect of nitrazepam was slightly faster than that of thioridazine. After thioridazine, but not after nitrazepam, the patients slept significantly longer than after placebo. Nitrazepam, but not thioridazine, significantly impaired patients' abilities to move and to conduct everyday activities. It is concluded that thioridazine is a suitable sleeping aid for psychogeriatric patients, but that nitrazepam should be avoided.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 128 , Issue 6 , June 1976 , pp. 566 - 569
Copyright
Copyright © Royal College of Psychiatrists, 1976 

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References

Andersen, T. & Lingjaerde, O. (1969) Nitrazepam as sleep-inducing agent. British Journal of Psychiatry, 115, 1393–7.Google Scholar
Crane, G. E. (1972) Prevention and management of tardive dyskinesia. American Journal of Psychiatry, 129, 126–7.Google Scholar
Ehrsson, H. & Tilly, A. (1973) Electron capture gas chromatography of nitrazepam in human plasma as methyl derivative. Analytical Letter, 6, 197–202.Google Scholar
Ferm, L. (1974) Behavioral activities in demented geriatric patients. Gerontologia Clinica, 16, 184–95.Google Scholar
Haider, I. (1968) A double-blind controlled trial of a non-barbiturate hypnotic, nitrazepam. British Journal of Psychiatry, 114, 337–43.CrossRefGoogle ScholarPubMed
Isaacs, B. & Walkey, F. A. (1964) The measurement of mental impairment in geriatric practice. Gerontologia Clinica, 6, 114–23.Google Scholar
Linnoila, M. (1973) Drug interaction on psychomotor skills related to driving. Annales Medicinae Experimentalis et Biologiae Fenniae, 51, 118–24.Google ScholarPubMed
Malpas, A., Rowan, A. J., Joyce, C. R. B. & Scott, D. F. (1970) Persistent behavioral and electroencephalographic changes after single doses of nitrazepam and amylobarbitone sodium. British Medical Journal, ii, 762–5.Google Scholar
Morgan, H., Scott, D. F. & Joyce, C. R. B. (1970) The effects of four hypnotic drugs and placebo on normal subjects' sleeping and dreaming at home. British Journal of Psychiatry, 117, 649–52.CrossRefGoogle ScholarPubMed
Randall, L. O., Schallek, W., Scheckel, C., Bagdon, R. E. & Rieder, J. (1965) Zur Pharmakologie von Mogadon, einem Schlafmittel mit neuartigem Wirkungsmechanismus. Schweizerische Medizinische Wochenschrift, 95, 334–7.Google Scholar
Saario, I., Linnoila, M. & Maki, M. (1975) Interaction of drugs with alcohol on human psychomotor skills related to driving: effect of sleep deprivation or two weeks' treatment with hypnotics. Journal of Clinical Pharmacology, 15, 52–9.CrossRefGoogle Scholar
Siegel, S. (1956) Nonparametric Statistics for Behavioral Sciences. New York: McGraw-Hill.Google Scholar
Silver, C. P. (1972) Simple methods of testing ability in geriatric patients. Gerontologia Clinica, 14, 110–22.Google Scholar
West, N. R., Rosenblum, M. P., Springe, H., Gold, S., Boehme, D. H. & Vogel, W. H. (1974) Assay procedures for thioridazine, trifluoperazine and their sulfoxides and determination of urinary excretion of these compounds in mental patients. Journal of Pharmaceutical Science, 63, 417–24.CrossRefGoogle ScholarPubMed
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