Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-10T09:14:32.536Z Has data issue: false hasContentIssue false
  • English
  • Français

Fluoxetine in breast-milk and developmental outcome of breast-fed infants

Published online by Cambridge University Press:  02 January 2018

K. Yoshida ,
B. Smith ,
M. Craggs  and
R. Channi Kumar
K. Yoshida
Affiliation:
Section of Perinatal Psychiatry, Institute of Psychiatry, University of London
B. Smith
Affiliation:
Section of Perinatal Psychiatry, Institute of Psychiatry, University of London
M. Craggs
Affiliation:
Section of Perinatal Psychiatry, Institute of Psychiatry, University of London
R. Channi Kumar*
Affiliation:
Section of Perinatal Psychiatry, Institute of Psychiatry, University of London
*
Professor R. Channi Kumar. Section of Perinatal Psychiatry, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF. Tel: 0171 9193212; Fax: 0171 7085919
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Selective serotonin reuptake inhibitors are currently the most widely prescribed antidepressant drugs. There are only four published studies of breast-feeding mothers and their infants in which the mothers were taking fluoxetine.

Method

Four mothers who took fluoxetine and their breast-fed infants were studied. Samples of plasma, breast-milk and urine were taken from the mothers and of plasma and urine from infants for assays of drug and metabolite concentrations. Bayley Scales of Infant Development were repeatedly used to assess cognitive and psychomotor development of the infants.

Results

Fluoxetine and norfluoxetine were detected in all samples of maternal plasma (range of total concentration 138–427 ng/ml) and in breast-milk (range 39–177 ng/ml). Amounts of both fluoxetine and norfluoxetine in infants' plasma and urine were below the lower limit of detection. All infants were observed to be developing normally and showed no abnormal findings on neurological examination.

Conclusions

Much larger databases are needed but these four cases do not provide any evidence to suggest that women who are maintained on therapeutic doses of fluoxetine should discontinue breast-feeding their infants if they wish to breast-feed.

Type
Papers
Information
The British Journal of Psychiatry , Volume 172 , Issue 2 , February 1998 , pp. 175 - 179
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bayley, N. (1969) Manual for the Bayley Scale of Infant Development. New York: Psychological Corporation.Google Scholar
Burch, K. J. & Wells, B. G. (1992) Fluoxetine/norfluoxetine concentrations in human milk. Pediatrics, 89. 676–677.Google Scholar
Chambers, C. D. Johnson, K. A. Dick, L. M. et al (1996) Birth outcomes in pregnant women taking fluoxetine. New England Journal of Medicine, 335, 1010–1056.Google Scholar
Fleiss, P. M. (1992) The effect of maternal medications on breast-feeding infants (letter). Journal of Human Lactation, 8, 7.Google Scholar
Isenberg, K. E. & Missouri, S. L. (1990) Excretion of fluoxetine in human breast milk, Journal of Clinical Psychiatry, 51, 4.Google ScholarPubMed
Lester, B. M. Cucca, J. Andreozzi, L. et al (1993) Possible association between fluoxetine hydrochloride and colic in an infant. Journal of American Academy of Child and Adolescent Psychiatry, 32, 6.Google Scholar
O'Hara, M. W. & Swain, A. M. (1996) Rates and risk of postpartum depression: a meta-analysis. International Review of Psychiatry, 8, 37–54.Google Scholar
Robert, E. (1996) Treating depression in pregnancy. New England Journal of Medicine, 335, 1056–1058.Google Scholar
Spitzer, R. L. Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria. Rationale and reliability Archives of General Psychiatry, 35, 773–782.Google Scholar
Stokes, P. E. (1993) Fluoxetine: A five year review. Clinical Therapeutics, 15, 216–243.Google ScholarPubMed
Taddio, A. Ito, S. & Koren, G. (1996) Excretion of fluoxetine and its metabolite, norfluoxetine, in human breast milk, Journal of Clinical Pharmacology, 36, 42–47.Google Scholar
Yoshida, K. & Kumar, R. (1996) Breast feeding and psychotropic drugs. International Review of Psychiatry, 8, 117–124.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.