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III. Relapse Postponement or Relapse Prevention? The Implications for Long-term Outcome

Published online by Cambridge University Press:  29 January 2018

D. A. Curson ,
T. R. E. Barnes ,
R. W. Bamber ,
S. D. Platt ,
S. R. Hirsch  and
J. C. Duffy
D. A. Curson*
Affiliation:
Bowden House Clinic, London Road, Harrow on the Hill, Middlesex H Al 3JL and Department of Psychiatry, Guy's Hospital Medical School, London
T. R. E. Barnes
Affiliation:
Department of Psychiatry, St George's Hospital Medical School, London
R. W. Bamber
Affiliation:
Department of Psychiatry, Guy's Hospital, London
S. D. Platt
Affiliation:
MRC Unit for Epidemiological Studies in Psychiatry, Royal Edinburgh Hospital, Edinburgh
S. R. Hirsch
Affiliation:
Charing Cross Hospital Medical School, London
J. C. Duffy
Affiliation:
Department of Statistics, University of Edinburgh, Edinburgh (From The Academic Unit for Clinical Psychopharmacology, Guy's Hospital Medical School, London)
*
∗Correspondence
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Summary

The relapse and admission histories revealed a positive correlation between number of schizophrenic episodes and time on maintenance medication, probably reflecting severity of illness. Relapse rates after drug discontinuation rose to 45% within 13 months. There were no differences of predictive value between those relapsing on or off medication. The relationship between relapse rates, drug treatment, and social outcome is complex; antipsychotic drugs may postpone relapse, and frequent relapses might inhibit improvement in social performance long after florid symptoms have been controlled by medication.

Type
Long-term Depot Maintenance of Chronic Schizophrenic Out-patients: The Seven Year Follow-up of the Medical Research Council Fluphenazine/Placebo Trial
Information
The British Journal of Psychiatry , Volume 146 , Issue 5 , May 1985 , pp. 474 - 480
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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