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Manic-Depressive Illness: A Comparative Study of Patients with and Without a Family History

Published online by Cambridge University Press:  29 January 2018

J. Mendlewicz ,
R. R. Fieve ,
J. D. Rainer  and
J. L. Fleiss
J. Mendlewicz
Affiliation:
Brussels University. Presently: Graduate Fellow of the Belgian American Educational Foundation; Senior Research Fellow, Department of Medical Genetics, New York State Psychiatric Institute, New York, New York
R. R. Fieve
Affiliation:
Department of Internal Medicine, New York Slate Psychiatric Institute and Associate Professor of Clinical Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York
J. D. Rainer
Affiliation:
Department of Medical Genetics, New York State Psychiatric Institute and Associate Professor of Clinical Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York
J. L. Fleiss
Affiliation:
Biometrics Research, New York State Department of Mental Hygiene and Assistant Professor, Divion of Biostatistics, Columbia University, New York, New York
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Extract

Early studies (21, 22, 25, 12) have pointed to a genetic component in the aetiology of manic-depressive disorders. More recently, careful clinical observation has suggested the division of the affective disorders into two distinct groups: the so-called bipolar or manic-depressive group and the unipolar type with recurrent depressions only (14, 27, 1). Although genetic differences in terms of family risk have been demonstrated between the so-called bipolar and unipolar psychoses, it is not yet evident whether each group constitutes a homogeneous entity. Moreover, the diagnosis of unipolar depressive disease for the authors cited above includes such syndromes as involutional psychotic reactions, psychotic depressive reactions, and probably also psychoneurotic depressions.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 120 , Issue 558 , May 1972 , pp. 523 - 530
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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