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Platelet Mao Activity and Evoked Potentials in the Identification of Subjects Biologically at Risk for Psychiatric Disorders

Published online by Cambridge University Press:  29 January 2018

R. D. Coursey ,
M. S. Buchsbaum  and
D. L. Murphy
R. D. Coursey
Affiliation:
Psychology Department, University of Maryland, College Park, Maryland 20742, U.S.A.
M. S. Buchsbaum
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health
D. L. Murphy
Affiliation:
Clinical Neuropharmacology Branch, National Institute of Mental Health
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Summary

Individuals potentially at risk for psychiatric disorders were identified by screening 375 college student volunteers for low platelet monoamine oxidase (MAO) activity levels. The lower and upper 10 per cent in MAO activity were administered a personal and family history interview, psychological tests and average evoked response (AER) electroencephalographic procedures. Results indicated that low MAO males and females were socially more active, had more psychiatric contact, and had relatives who were psychiatric-ally more disturbed than high MAO subjects. Low MAO males had more convictions, experimented more with illegal drugs and had elevated scores on the MMPI. AER criteria further defined a high risk group of low MAO-AER augmenters which had more suicides among their relatives and higher scores on the schizophrenia scale of the MMPI.

Type
Papers
Information
The British Journal of Psychiatry , Volume 134 , Issue 4 , April 1979 , pp. 372 - 381
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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References

Buchsbaum, M. S. (1975) Average evoked response augmenting/reducing in schizophrenia and affective disorders. In The Biology of the Major Psychoses (ed. D. X. Freedman). New York: Raven Press.Google Scholar
Buchsbaum, M. S. (1977) The middle evoked response components and schizophrenia. Schizophrenia Bulletin, 3, 93–104.Google Scholar
Buchsbaum, M. S., Coursey, R. D. & Murphy, D. L. (1976) The biochemical high-risk paradigm: behavioral and familial correlates of low platelet monoamine oxidase activity. Science, 194, 339–41.CrossRefGoogle ScholarPubMed
Buchsbaum, M. S., Haier, R. & Murphy, D. L. (1977) Suicide attempts, platelet monoamine oxidase and the average evoked response. Acta Psychiatrica Scandinavia, 56, 69–79.Google Scholar
Buchsbaum, M. S., Landau, S., Murphy, D. L. & Goodwin, F. (1973) Average evoked response in bipolar and unipolar affective disorders: Relationship to sex, age of onset and monoamine oxidase. Biological Psychiatry, 7, 199–212.Google Scholar
Buchsbaum, M. S., Post, R. M. & Bunney, W. E. (1977) Average evoked responses in a rapidly cycling manic depressive patient. Biological Psychiatry, 12, 83–99.Google Scholar
Buss, A. H. & Plomin, R. (1975) A Temperament Theory of Personality Development. New York: Wiley.Google Scholar
Dahlstrom, W. G., Welsh, G. S. & Dahlstrom, L. (1972) An MMPI Handbook (rev ed). Minneapolis: University of Minnesota Press.Google Scholar
DHEW (1971) Adoptions in 1971. DHEW Publ # (SRS) 73–03259 NCSS Report E-10.Google Scholar
Donnelly, C. H. & Murphy, D. L. (1977) Substrate and inhibitor-related characteristics of human platelet monoamine oxidase. Biochemical Pharmacology, 26, 853–8.Google Scholar
Drake, L. & Oetting, E. (1959) An MMPI Codebook for Counselors. Minneapolis: University of Minnesota Press.Google Scholar
Falek, A. & Moser, H. M. (1975) Classification in schizophrenia. Archives of General Psychiatry, 32, 59–67.Google Scholar
Farnsworth, D. (1966) Psychiatry, Education, and the Young Adult. Springfield, Ill.: Charles C. Thomas.Google Scholar
Fowler, R. C. & Tsuang, M. T. (1975) Spouses of schizophrenics: A blind comparative study. Comprehensive Psychiatry, 16, 339–42.Google Scholar
Garmezy, N. & Streitman, S. (1974) Children at risk: The search for the antecedents of schizophrenia. Part 1. Conceptual models and research methods. Schizophrenia Bulletin, 1 (Experimental Issue No. 8), 14–90.CrossRefGoogle Scholar
Guze, S. B., Wolfgram, E. D., McKinney, J. K. & Cantwell, D. P. (1967) Psychiatric illness in the families of convicted criminals. A study of 519 first-degree relatives. Diseases of the Nervous System, 28, 651–9.Google Scholar
Heston, L. L. (1966) Psychiatric disorders in foster home reared children of schizophrenic mothers. British Journal of Psychiatry, 112, 819–25.CrossRefGoogle ScholarPubMed
Hutchings, B. & Mednick, S. A. (1974) Registered criminality in the adoptive and biological parents of registered male adoptees. In Genetics, Environment, and Psychopathology (ed. S. A. Mednick et at). Amsterdam: North-Holland/Elsevier.Google Scholar
Kallman, F. J. (1938) The Genetics of Schizophrenia. New York: J. J. Augustin.Google Scholar
Kety, S. S., Rosenthal, D., Wender, P. H. & Schulsinger, P. (1968) The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. Journal of Psychiatric Research, 6, 345–62.Google Scholar
Kiersch, T. A. & Nikelly, A. G. (1966) The schizophrenic in college. Archives of General Psychiatry, 15, 54–8.Google Scholar
Kirkegaard-Sorensen, L. & Mednick, S. A. (1975) Registered criminality in families with children at high risk for schizophrenia. Journal of Abnormal Psychology, 81, 197–204.Google Scholar
Lohrenz, J. & Goldstein, S. (1968) Psychotic reactions in college students. Canadian Psychiatric Association Journal, 13, 109–13.CrossRefGoogle ScholarPubMed
Major, L. F. & Murphy, D. L. (1978) Platelet and plasma amine oxidase activity in alcoholic individuals. British Journal of Psychiatry (in press).CrossRefGoogle Scholar
Mishara, B. L., Baker, A. H. & Mishara, T. T. (1976) The frequency of suicide attempts: A retrospective approach applied to college students. American Journal of Psychiatry, 133, 841–4.Google ScholarPubMed
Murphy, D. L., Belmaker, R. H., Buchsbaum, M. S. et al (1977) Biogenic amine-related enzymes and personality variations in normals. Psychological Medicine, 7, 149–57.CrossRefGoogle ScholarPubMed
Murphy, D. L., Belmaker, R. H. & Wyatt, R. J. (1974) Monoamine oxidase in schizophrenia and other behavioral disorders. Journal of Psychiatric Research, 11, 221–47.Google Scholar
Murphy, D. L. & Buchsbaum, M. S. (1978) Neurotransmitter—Related enzymes and psychiatric diagnostic entities. In Current Issues in Psychiatric Diagnoses (ed. R. Spitzer & D. Klein). New York: Raven.Google Scholar
Murphy, D. L., Wright, C., Buchsbaum, M. S., Nichols, A., Costa, J. L. & Wyatt, R. J. (1976) Platelet and plasma amine oxidase activity in 680 normals: sex and age differences and stability over time. Biochemical Medicine, 16, 254–65.Google Scholar
Peterson, D. R. (1954) The diagnosis of subclinical schizophrenia. Journal of Consulting Psychology, 18, 198–200.Google Scholar
Potkin, S. G., Cannon, H. E., Murphy, D. L. & Wyatt, R. J. (1978) Paranoid schizophrenia: A different disorder ? New England Journal of Medicine, 298, 61–6.Google Scholar
Redmond, D. E. & Murphy, D. L. (1975) Behavioral correlates of platelet monoamine oxidase in rhesus monkeys. Psychosomatic Medicine, 37, 80.Google Scholar
Reifler, C. B. & Liptzin, M. B. (1969) Epidemiological studies of college mental health. Archives of General Psychiatry, 20, 528–40.CrossRefGoogle Scholar
Rosenthal, D., Wender, P. H., Kety, S. S., Schulsinger, F., Welner, J. & Ostergaard, L. (1968) Schizophrenics' offspring reared in adoptive homes, in The Transmission of Schizophrenia (ed. D. Rosenthal and S. S. Kety). Oxford: Pergamon.Google Scholar
Ross, M. (1969) Suicide among college students. American Journal of Psychiatry, 126, 220–5.Google Scholar
Sandler, M., Youdin, M. B. & Harington, E. (1974) A phenylethylamine oxidizing defect in migraine. Nature, 250, 335–7.Google Scholar
Schooler, C., Zahn, T. P., Murphy, D. L. & Buchsbaum, M. S. (1978) Psychological correlates of monoamine oxidase activity in normals. Journal of Nervous and Mental Disease (in press).CrossRefGoogle Scholar
Schildkraut, J. J., Orsulak, P. S., Schatzberg, A. F., Cole, J. O., Gudeman, J. E. & Rohde, W. A. (1978) Elevated platelet MAO activity in schizophrenia-related depressive disorders. American Journal of Psychiatry, 135, 110–12.Google ScholarPubMed
Schulsinger, F. (1972) Psychopathy: Heredity and environment. International Journal of Mental Health, 1, 190–206.Google Scholar
Schulsinger, H. (1976) A ten year follow-up of children of schizophrenic mothers. Acta Psychiatrica Scandanavia, 53, 371–86.Google Scholar
Stephens, D. A., Atkinson, M. W., Kay, D. W. K., Roth, M. & Garside, R. (1975) Psychiatric morbidity in parents and sibs of schizophrenics and non-schizophrenics. British Journal of Psychiatry, 127, 97–108.CrossRefGoogle ScholarPubMed
Stillman, R. C., Wyatt, R. J., Murphy, D. L. & Rauscher, F. P. (1978) Low platelet monoamine oxidase activity and chronic marijuana use. Life Sciences (in press).CrossRefGoogle Scholar
Weiss, R. J., Segal, B. E. & Sokel, R. (1965) Epidemiology of emotional disturbance in a men's college. Journal of Nervous and Mental Disease, 141, 240–50.Google Scholar
Wyatt, R. J. & Murphy, D. L. (1976) Low platelet monoamine oxidase activity and schizophrenia. Schizophrenia Bulletin, 2, 77–89.Google Scholar
Zuckerman, M. (1972) Manual and research report for the Sensation Seeking Scale, University of Delaware.Google Scholar
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