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Regional Brain Metabolism During Auditory Hallucinations in Chronic Schizophrenia

Published online by Cambridge University Press:  02 January 2018

J. M. Cleghorn ,
E. S. Garnett ,
C. Nahmias ,
G. M. Brown ,
R. D. Kaplan ,
H. Szechtman ,
B. Szechtman ,
S. Franco ,
S. W. Dermer  and
P. Cook
J. M. Cleghorn*
Affiliation:
McMaster University, 1200 Main Street West, Hamilton, Ontario Canada L8N 3Z5
E. S. Garnett
Affiliation:
Nuclear Medicine Department, McMaster University
C. Nahmias
Affiliation:
Radiology, McMaster University
G. M. Brown
Affiliation:
Biomedical Sciences and Psychiatry, McMaster University
R. D. Kaplan
Affiliation:
Psychiatry, McMaster University
H. Szechtman
Affiliation:
Biomedical Sciences, McMaster University
B. Szechtman
Affiliation:
Psychiatry, McMaster University
S. Franco
Affiliation:
Psychiatry, McMaster University
S. W. Dermer
Affiliation:
Hamilton Program for Schizophrenia, McMaster University
P. Cook
Affiliation:
Hamilton Program for Schizophrenia, McMaster University
*
∗Correspondence
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Abstract

Regions of the brain involved in language and attention were studied using [18F]-fluorodeoxyglucose in PET. In nine chronic DSM–III schizophrenic patients who had persistent auditory hallucinations, ten who had recovered from hallucinations and ten normal controls. In none of the regions examined was metabolic activity significantly different in hallucinating patients compared with that in other groups. However, a pattern of seven significant correlations of metabolic activity between language regions and between frontal and parietal cortex characterised the hallucinating but not the other groups. Three of the seven correlations were significantly greater in hallucinating patients than in the two other groups, and six were greater in hallucinating patients than controls. Metabolism in Broca's region and its right-hemisphere homologue correlated positively and significantly in the hallucinating group, as it did in anterior cingulate and left superior temporal areas, and in right frontal and parietal areas. Hallucination ratings correlated with metabolism in the anterior cingulate region.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 4 , October 1990 , pp. 562 - 570
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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Footnotes

Presented by J. M. Cleghorn to the 43rd Annual Convention of the Society of Biological Psychiatry, 4–8, May 1988, Montreal, Canada, and, in part, by E. S. Garnett to the Royal College of Psychiatrists, September 1987, London, England.

References

Adams, K. M., Brown, G. G. & Grant, I. (1984) Analysis of covariance as a remedy for demographic mismatch of research subject groups: some sobering simulations. Journal of Clinical and Experimental Neuropsychology, 7, 445–462.Google Scholar
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Andreasen, N. C. (ed) 1986) Can Schizophrenia be Localized in the Brain? Washington, DC: APA.Google Scholar
Andreasen, N. C. (1988) Brain imaging: applications in psychiatry. Science, 239, 1381–1388.Google Scholar
Andreasen, N. C. & Olsen, S. (1982) Negative v. positive schizophrenia: definition and validation. Archives of General Psychiatry, 39, 784–788.CrossRefGoogle ScholarPubMed
Benes, F. M., Majocha, R., Bird, E. D., et al (1987) Increased vertical axon counts in cingulate cortex of schizophrenics. Archives of General Psychiatry, 44, 1011–1021.Google Scholar
Bick, P. A. & Kinsbourne, M. (1987) Auditory hallucinations and subvocal speech in schizophrenic patients. American Journal of Psychiatry, 144, 222–225.Google Scholar
Bowers, M. B. (1977) Psychoses precipitated by psychotomimetic drugs: a follow-up study. Archives of General Psychiatry. 34, 832–835.Google Scholar
Bowers, M. B. (1987) The role of drugs in the production of schizophreniform psychoses and related disorders. In Psychopharmacology: The Third Generation of Progress (ed. H. Meltzer). New York: Raven Press.Google Scholar
Brownell, G. L., Kearfott, K. J., Kairento, A-L., et al (1983) Quantitation of regional cerebral glucose metabolism. Journal of Computer Assisted Tomography, 7, 919–924.Google Scholar
Clark, C., Carson, R., Kessler, R., et al (1985) Alternative statistical models for the examination of clinical positron emission tomography/fluorodeoxyglucose data. Journal of Cerebral Blood Flow and Metabolism, 5, 142–150.CrossRefGoogle ScholarPubMed
Cleohorn, J. M., Garnett, E. S., Nahmias, C., et al (1989) Increased frontal and reduced paretal glucose metabolism in acute untreated schizophrenia. Psychiatry Research, 28, 119–133.Google Scholar
Damasio, A., Bellugi, V., Damasio, H., et al (1986) Sign language aphasia during left hemisphere amytal injection. Nature, 322, 363–365.Google Scholar
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry, 35, 837–84.Google Scholar
Geschwind, N. & Levitsky, W. (1968) Human brain – left and right asymmetries in temporal speech region. Science, 161, 186–187.Google Scholar
Gloor, P., Olivier, A., Quesney, L. F., et al (1982) The role of the limbic system in experimental phenomena of temporal lobe epilepsy. Annals of Neurology, 12, 129–144.Google Scholar
Golden, C., Moses, J., Zelazowski, R., et al (1980) Cerebral ventricular size and neuropsychological impairment in chronic schizophrenics. Archives of General Psychiatry, 37, 619–626.Google Scholar
Gould, L. N. (1949) Auditory hallucinations in subvocal speech: objective study in a case of schizophrenia. Journal of Nervous and Mental Disease, 109, 418–427.Google Scholar
Gur, R. E., Skolnick, B. E., Gur, R. C., et al (1983) Brain function in psychiatric disorders: I. Regional cerebral blood flow in unmedicated schizophrenics. Archives of General Psychiatry, 40, 1250–1254.Google Scholar
Gur, R. E., Resnick, S. M., Alavi, A., et al (1987) Regional brain function in schizophrenia. I. A positron emission tomography study. Archives of General Psychiatry, 44, 119–125.Google Scholar
Hamilton, M. (1984) Fish's Schizophrenia. New York: Wright.Google Scholar
Hays, W. M. (1975) Statistics: Probability, Inferences and Decision. New York: Holt, Rinehart & Winston.Google Scholar
Hoffman, R. E. (1986) Verbal hallucinations and language production processes in schizophrenia. Behavioral and Brain Sciences, 9, 503–548.Google Scholar
Horowitz, M. J. & Adams, J. E. (1970) Hallucinations on brain stimulation: evidence for revision of the Penfield hypothesis. In Origin and Mechanism of Hallucinations (ed. W. Keup) New York: Plenum.Google Scholar
Horwitz, B., Duara, R. & Rapaport, S. I. (1984) Intercorrelations of glucose metabolic rates between regions: application to healthy males in a state of reduced sensory input. Journal of Cerebral Blood Flow and Metabolism, 4, 484–499.Google Scholar
Horwitz, B., Grady, C. L., Schlageter, N. L., et al (1987) Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease. Brain Research, 407, 294–306.Google Scholar
Horwitz, B., Rumsey, J. M., Grady, C. L., et al (1988) The cerebral metabolic landscape in autism. Archives of Neurology, 45, 749–755.Google Scholar
Hubel, D. H. & Wiesel, T. N. (1959) Receptive fields of single neurones in the cat's striate cortex. Journal of Physiology, 574–591.Google ScholarPubMed
MacLean, P. D. (1985) Brain evolution relating to family play and the separation call. Archives of General Psychiatry, 42, 405–417.Google Scholar
Mahl, G. F., Rothenberg, A., Delgado, J. M. R., et al (1964) Psychological response in the human to intracerebral electrical stimulation. Psychosomatic Medicine, 26, 337–368.Google Scholar
Mazziotta, J. C., Phelps, M. E., Carson, R. E., et al (1982) Tomographic mapping of human cerebral metabolism: sensory deprivation. Annals of Neurology, 12, 435–444.Google Scholar
McKenna, P. J. (1987) Pathology, phenomenology and the dopamine hypothesis of schizophrenia. British Journal of Psychiatry, 151, 288–301.Google Scholar
Müller-Preuss, P., Newman, J. D. & Jurgens, U. (1980) Anatomical and physiological evidence for a relationship between the ‘angular’ vocalization area and the auditory cortex in the squirrel monkey. Brain Research, 202, 307–315.Google Scholar
Nahmias, C. (1984) The McMaster positron emission tomograph: design and evaluation. Nuclear Instruments and Methods, 1, 113–114.Google Scholar
Ojemann, G. A. (1983) Organization for language from the perspective of electrical stimulation mapping. Behavioral and Brain Sciences, 6, 189–230.Google Scholar
Penfield, W., Rasmussen, T. (1950) The Cerebral Cortex of Man. New York: Macmillan.Google Scholar
Penfield, W. & Roberts, L. (1959) Speech and Brain Mechanisms. New Jersey: Princeton University Press.Google Scholar
Penfield, W., & Perrot, P. (1963) The brain record of auditory and visual experience. Brain, 86, 595–596.Google Scholar
Petersen, S. E., Fox, E. T., Posner, M. I., et al (1988) Positron emission tomography studies of the cortical anatomy of single word processing. Nature, 331, 585–589.Google Scholar
Posner, M. I., Petersen, S. E., Fox, P. T., et al (1988) Localization of cognitive operations in the human brain. Science, 240, 1627–1631.Google Scholar
Prohovnik, I., Hakansson, K. & Risberg, J. (1980) Observations on the functional significance of regional cerebral blood flow in “resting” normal subjects. Neuropsychologia, 18, 203–217.Google Scholar
Sheppard, G., Gruzelier, J., Manchanda, R., et al (1983) “O positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet, ii, 1448–1452.Google Scholar
Soncrant, T. T., Horwitz, B., Holloway, H. W., et al (1986) The pattern of functional coupling of brain regions in the awake rat. Brain Research, 369, 1–11.Google Scholar
Szechtman, H., Nahmias, C., Garnett, E. S., et al (1988) Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Archives of General Psychiatry, 45, 523–532.Google Scholar
Volkow, N. D., Wolf, A. P., Brodie, J. D., et al (1988) Brain interactions in chronic schizophrenics under resting and activation conditions. Schizophrenia Research, 1, 47–53.Google Scholar
Weiser, H. G. (1983) Depth recorded limbic seizures and psychopathology. Neuroscience and Biobehavioural Review, 7, 427–440.Google Scholar
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