Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-13T03:05:56.949Z Has data issue: false hasContentIssue false
  • English
  • Français

Amphetamine-Induced Dysphoria in Postmenopausal Women

Published online by Cambridge University Press:  29 January 2018

Uriel Halbreich ,
Gregory Asnis ,
Donald Ross  and
Jean Endicott
Uriel Halbreich*
Affiliation:
Division of Behavioral Endocrinology, Department of Psychiatry, Albert Einstein College of Medicine, New York
Gregory Asnis
Affiliation:
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York
Donald Ross
Affiliation:
Computer Center, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York
Jean Endicott
Affiliation:
Research Assessment and Training Unit, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York
*
∗Correspondence: Department of Psychiatry, Montefiore Hospital and Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, Bronx, New York 10467, USA.
Get access Rights & Permissions [Opens in a new window]

Summary

Dextroamphetamine (0.15 mg/kg) intravenously administered to a group of normal postmenopausal women induced a dysphoric reaction with drowsiness, annoyance, sadness and anger. Young normal men, receiving the same dosage, responded with elation of mood and alertness. It is suggested that age and hypoestrogenism may alter the behavioural response to amphetamine.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 138 , Issue 6 , June 1981 , pp. 470 - 473
Copyright
Copyright © Royal College of Psychiatrists, 1981 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Angrist, B. & Sudilorsky, A. (1978) Central nervous system stimulants. In Handbook of Psychopharmacology, Vol. II: Stimulants (eds. Iversen, L. L. Iversen, S. D. and Snyder, S. H.). Pp 111–165. New York, London: Plenum Press.Google Scholar
Angrist, B. & Gershon, S. (1980) The phenomenology of experimentally-induced amphetamine psychosis—preliminary observation. Biological Psychiatry, 2, 95–107.Google Scholar
Bertler, A. (1961) Occurrence and localization of catecholamines in the human brain. Acta Physiologica Scandinavica, 51, 97–107.CrossRefGoogle Scholar
Checkley, S. A. (1978) A new distinction between the euphoric and the antidepressant effects of methlyamphetamine. British Journal of Psychiatry, 133, 416–423.Google Scholar
Dixon, W. J. & Brown, M. B. (eds.) (1977) Biomedical Computer Programs P-Series. Berkeley: University of California Press.Google Scholar
Estler, C. J. (1975) Effect of amphetamine-type psychostimulants on brain metabolism. Advances in Pharmacology and Chemistry, 13, 305–357.Google Scholar
Gunne, L. M. Anggard, E. & Jonsson, L. W. (1972) Clinical trials with amphetamine blocking drugs. Psychiatry, Neurology, Neurochemistry (Amst.), 75, 225–226.Google ScholarPubMed
Halbreich, U. Asnis, G. M. Halprin, F. Tabrizi, M. A. & Sachar, E. J. (1980) Diurnal growth hormone responses to dextroamphetamine in normal young men and postmenopausal women. Psychoneuroendocrinology, 5, 339–344.CrossRefGoogle Scholar
Janowski, D. S. El-Yussef, M. D. Davis, M. M. & Sekerke, H. J. (1973) Provocation of schizophrenic symptoms by intravenous administration of methylphenidate. Archives of General Psychiatry, 28, 185–191.Google Scholar
Janowski, D. S. & Davis, J. B. (1974) Dopamine psychomotor stimulants and schizophrenia: Effects of methylphenidate and the sterioisomers of amphetamines in schizophrenics. In Neuropsychopharmacology of Monoamines and Their Regulatory Enzymes (ed. Usdin, E.). Pp 317–323. New York: Raven Press.Google Scholar
Janowski, D. S. & Davis, J. B. (1976) Methylphenidate, dextroamphetamine levamphetamine effects on schizophrenic symptoms. Archives of General Psychiatry, 33, 304–308.Google Scholar
Jonsson, L. W. (1972) Pharmacological blockade of amphetamine effects in amphetamine dependent subjects. European Journal of Clinical Pharmacology, 4, 206–211.CrossRefGoogle Scholar
Jonsson, L. W. Gunne, L. M. & Anggard, E. (1969) Effects of alphamethyltyrosine in amphetamine dependent subject Pharmacologica Clinica, 2, 27–29.CrossRefGoogle Scholar
Kleiber, E. L. Kobayashi, Y. Broverman, D. M. & Hall, F. (1971) Plasma MAO activity in regularly menstruating women and in amenorrheic women receiving cyclic treatment with estrogens and progestin. Journal of Clinical Endocrinology, 33, 630–637.Google Scholar
Lasagna, L. von Felsinger, J. M. & Beecher, H. K. (1955) Drug-induced mood changes in man. I. Observations on healthy subjects, chronically ill patients, and ‘post-addicts's. Journal of the American Medical Association, 157, 1006–1020.CrossRefGoogle Scholar
McGeer, E. & McGeer, P. L. (1976) Neurotransmitter metabolism in the aging brain. In Neurobiology of Aging (eds. Terry, R. D. and Gerhson, S.). Pp 389–403. New York: Raven Press.Google Scholar
Martin, W. R. Sloan, J. W. Sapira, J. D. & Jasinski, D. R. (1971) Physiological, subjective and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine and methylphenidate in man. Clinical Pharmacology and Therapeutics, 12, 245–258.CrossRefGoogle ScholarPubMed
Moore, R. E. (1978) Amphetamines: Biochemical and behavioral actions in animals. In Handbook of Psychopharmacology, Vol. II: Stimulants, (eds. Iversen, L. L. Iversen, S. D. and Snyder, S. H.). Pp 41–98. New York, London: Plenum Press.Google Scholar
Nicholson, A. N. (1978) Visual analogue scales and drug effects in man. British Journal of Clinical Pharmacology, 6, 3–4.Google Scholar
Reifenstein, F. C. Jr. & Davidoff, E. (1939) Benzedrine sulfate therapy, the present status. New York State Journal of Medicine, 1939, 42–57.Google Scholar
Robinson, D. S. (1975) Changes in monoamine oxidase and monoamines with human development and aging. Federal Proceedings, 34, 103–107.Google Scholar
Von Felsinger, J. M. Lasagna, L. & Beecher, H. K. (1955) Drug-induced mood changes in man. 2. Personality and reaction to drugs. Journal of the American Medical Association, 157, 1113–1119.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.