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Are Polioviruses a Cause of Schizophrenia?

Published online by Cambridge University Press:  02 January 2018

John M. Eagles*
Affiliation:
Ross Clinic, Royal Cornhill Hospital, Cornhill Road, Aberdeen AB9 2ZF

Abstract

Pre-natal infection with polioviruses could contribute to the subsequent development of schizophrenia. The hypothesis draws support from the declining incidence of schizophrenia, the excess of schizophrenic winter births, and the increased rates of schizophrenia among West Indian immigrants. There are parallels with other late sequelae of poliovirus infections. These postulations generate a testable hypothesis of a genetic link between schizophrenia and susceptibility to poliomyelitis.

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Copyright
Copyright © The Royal College of Psychiatrists, 1992 

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References

Alvord, E. C., Jahnke, U., Fischer, E. H., et al (1987) The multiple causes of multiple sclerosis: the importance of age of infections in childhood. Journal of Child Neurology, 2, 313321.CrossRefGoogle ScholarPubMed
Ashley, D. E., McCaw, A. & Clarke, R. (1985) A historical review of poliomyelitis and immunisation in Jamaica 1954–1982. Journal of Tropical Pediatrics, 31, 323327.CrossRefGoogle ScholarPubMed
Begg, N. T., Chamberlain, R. & Roebuck, M. (1987) Paralytic poliomyelitis in England and Wales 1970–1984. Epidemiology and Infection, 99, 97106.CrossRefGoogle Scholar
Best, J. M. & Banatvala, J. E. (1990) Congenital virus infections. British Medical Journal, 300, 11511152.CrossRefGoogle ScholarPubMed
Bradbury, T. N. & Miller, G. A. (1985) Season of birth in schizophrenia: a review of evidence, methodology and etiology. Psychological Bulletin, 98, 569594.CrossRefGoogle ScholarPubMed
Chopra, K., Kundu, S. & Choudhury, D. S. (1989) Antibody response of infants in tropics to five doses of oral polio vaccine. Journal of Tropical Pediatrics, 35, 1923.CrossRefGoogle ScholarPubMed
Christie, A. B. (1987) Acute poliomyelitis. In Infectious Diseases: Epidemiology and Clinical Practice (4th edn), vol. 2, pp. 817856. Edinburgh: Churchill-Livingstone Google Scholar
Crow, T. J. (1983) Is schizophrenia an infectious disease? Lancet i, 173175.CrossRefGoogle Scholar
Crow, T. J. (1990) Trends in schizophrenia. Lancet, 335, 851.CrossRefGoogle Scholar
Dalen, P. (1990) Does age incidence explain all season-of-birth effects in the literature? Schizophrenia Bulletin, 16, 1112.CrossRefGoogle ScholarPubMed
Der, O., Gupta, S. & Murray, R. M. (1990) Is schizophrenia disappearing? Lancet, 335, 513516.CrossRefGoogle Scholar
Eagles, J. M. (1991) Is schizophrenia disappearing? British Journal of Psychiatry, 158, 834835.CrossRefGoogle Scholar
Eagles, J. M. & Whalley, L. J. (1985) Decline in the diagnosis of schizophrenia among first admissions to Scottish mental hospitals from 1969–1978. British Journal of Psychiatry, 146, 151154.CrossRefGoogle Scholar
Eagles, J. M., Hunter, D. & McCance, C. (1988) Decline in the diagnosis of schizophrenia among first contacts with psychiatric services in North-East Scotland 1969–1984. British Journal of Psychiatry, 152, 793798.CrossRefGoogle ScholarPubMed
Graham, P. M. (1990) Trends in schizophrenia. Lancet, 335, 852.Google Scholar
Hare, E. H. (1987) Epidemiology of schizophrenia and affective psychoses. British Medical Bulletin, 43, 514530.CrossRefGoogle ScholarPubMed
Harrison, G., Owens, D., Holton, A., et al (1988) A prospective study of severe mental disorder in Afro-Caribbean patients. Psychological Medicine, 18, 643657.CrossRefGoogle ScholarPubMed
Howard, R. S., Wiles, G. M. & Spencer, G. T. (1988) The late sequelae of poliomyelitis. Quarterly Journal of Medicine, 66, 219232.Google ScholarPubMed
Joyce, P. R. (1987) Changing trends in first admissions and readmissions for mania and schizophrenia in New Zealand. Australian and New Zealand Journal of Psychiatry, 21, 8286.CrossRefGoogle ScholarPubMed
Lewis, M. S. (1989) Age incidence and schizophrenia: part I: The season of birth controversy. Schizophrenia Bulletin, 15, 5973.CrossRefGoogle ScholarPubMed
Lewis, S. W. (1989) Congenital risk factors for schizophrenia. Psychological Medicine, 19, 513.CrossRefGoogle ScholarPubMed
Martyn, C. N., Barker, D. J. P. & Osmond, C. (1988) Motor neuron disease and past poliomyelitis in England and Wales. Lancet, i, 13191322.CrossRefGoogle Scholar
McGovern, D. & Cope, R. V. (1987) First psychiatric admission rate of first and second generation Afro-Caribbeans. Social Psychiatry, 22, 139149.CrossRefGoogle Scholar
Miller, D. L. & Galbraith, N. S. (1965) Surveillance of the safety of oral poliomyelitis vaccine in England and Wales, 1962–1964. British Medical Journal, 2, 504509.CrossRefGoogle Scholar
Mortimer, P. P. & Cunningham, P. (1975) Sero-immunity to poliovirus in children and young women: England 1972–1974. Journal of Hygiene, 74, 283287.CrossRefGoogle Scholar
Munk-Joroensen, P. (1986) Decreasing first admission rates of schizophrenia among males in Denmark from 1970 to 1984: changing diagnostic patterns? Acta Psychiatrics Scandinavica, 73, 645650.CrossRefGoogle Scholar
Prince, M. J. & Phelan, M. C. (1990) Trends in schizophrenia. Lancet, 335, 851852.Google Scholar
Raymond, C. A. (1986) Decades after polio epidemics, survivors report new symptoms. Journal of the American Medical Association, 225, 13971399.Google Scholar
Roberts, G. W. (1991) Schizophrenia: a neuropathological perspective. British Journal of Psychiatry, 158, 817.CrossRefGoogle ScholarPubMed
Siddique, T., McKinney, R., Hung, W-Y., et al (1988) The poliovirus sensitivity (PVS) gene is on chromosome 19 q 12–q13.2. Genomics, 3, 156160.CrossRefGoogle Scholar
Torrey, E. F., Rawlings, R. & Waldman, I. N. (1988) Schizophrenic births and viral diseases in two states. Schizophrenia Research, 1, 7377.CrossRefGoogle ScholarPubMed
Torrey, E. F. & Bowler, A. E. (1990) The seasonality of schizophrenic births: a reply to Marc S. Lewis. Schizophrenia Bulletin, 16, 13.CrossRefGoogle ScholarPubMed
Watson, C. G. (1990) Schizophrenic birth seasonality and the age-incidence artifact. Schizophrenia Bulletin, 16, 510.CrossRefGoogle ScholarPubMed
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