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Ascorbic Acid and Chronic Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Brice Pitt  and
Norman Pollitt
Brice Pitt
Affiliation:
Churchill Clinic, Princess Alexandra Hospital, Harlow, Essex. (Late Consultant Psychiatrist, Claybury Hospital, Woodford Bridge, Essex)
Norman Pollitt
Affiliation:
Roche Products Ltd., Welwyn Garden City, Herts.; Clinical Assistant, Department of Medicine, West London Hospital, London, W.6
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Extract

Milner (1963), using urinary saturation tests to determine ascorbic acid levels in a group of male chronic schizophrenics, reported that far higher doses of ascorbic acid were required to achieve saturation in that group than in normal subjects. Briggs (1962) observed hypovitaminosis C in schizophrenics, and postulated a disturbance of ascorbic acid metabolism which could be relevant to the biochemical basis of schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 118 , Issue 543 , February 1971 , pp. 227 - 228
Copyright
Copyright © The Royal College of Psychiatrists, 1971 

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References

Briggs, M. D. (1962). ‘Possible relations of ascorbic acid, ceruloplasmin and toxic aromatic metabolites in schizophrenia.’ New Zealand Medical Journal, 61, 229.Google ScholarPubMed
Denson, K. W., and Bowers, E. F. (1961). ‘The determination of ascorbic acid in white blood cells. A comparison of white blood cells, ascorbic acid and phenolic acid excretion in elderly patients.’ Clinical Science, 21, 157.Google ScholarPubMed
Leitner, Z. A., and Church, I. E. (1956). ‘Nutritional studies in a mental hospital.’ Lancet, i, 565.Google Scholar
Milner, G. (1963). ‘Ascorbic acid in chronic psychiatric patients—a controlled trial.’ British Journal of Psychiatry, 109, 294.Google Scholar
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