Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-27T14:06:01.908Z Has data issue: false hasContentIssue false
  • English
  • Français

A Biochemical Study of Short-Cycle Manic-Depressive Psychosis in Mental Defectives

Published online by Cambridge University Press:  29 January 2018

Graham J. Naylor ,
Andrew H. Reid ,
David A. T. Dick  and
Elizabeth G. Dick
Graham J. Naylor
Affiliation:
Department of Psychiatry, The University, Dundee
Andrew H. Reid
Affiliation:
Royal Dundee Liff Hospital, By Dundee
David A. T. Dick
Affiliation:
Department of Anatomy, The University, Dundee
Elizabeth G. Dick
Affiliation:
Department of Anatomy, The University, Dundee
Get access Rights & Permissions [Opens in a new window]

Summary

Four mentally defective patients who were suffering from short-cycle manic-depressive psychosis were each studied under metabolic ward conditions for about six months. Weekly estimations of erythrocyte Na-K ATPase activity, ouabain sensitive potassium influx, sodium concentration, whole blood cell ATP concentration and blood haematocrit were made. The findings in each patient differed, but the erythrocyte Na-K ATPase activity, sodium and ATP concentration appeared to show cyclic changes related to, though out of phase with, the clinical state.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 128 , Issue 2 , February 1976 , pp. 169 - 180
Copyright
Copyright © Royal College of Psychiatrists, 1976 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adam, H. (1962) In Methods of Enzymatic Analysis (cd. Bermeyer). Weilheim.Google Scholar
Bojanovsky, J. (1971) Einige biochemische Korrelate einer 48-stündigen periodischen Psychose. Psychiatric Clinics, 4, 336–46.Google Scholar
Bonting, S. L. (1970) Sodium-potassium activated adenosinetriphosphatase and cation transport. In Membrane and Ion Transport, Volume 1 (ed. Bittar, E. E.), pp. 255–363. New York: Wiley Interscience.Google Scholar
Bunney, W. E., Hartman, E. L. & Mason, J. W. (1965) Study of a patient with 48 hour manic depressive cycles. Archives of General Psychiatry, 12, 619–25.Google Scholar
Coen, P. J., Gomme, E. D. & Kendall, M. G. (1969) Lagged relationships in economic forecasting. Journal of the Royal Statistical Society, 132, 133–63.Google Scholar
Coppen, A. J. & Shaw, D. M. (1963) Mineral metabolism in melancholia. British Medical Journal, ii, 1439–44.Google Scholar
Coppen, A. J. & Shaw, D. M., Malleson, A. & Costain, R. (1966) Mineral metabolism in mania. British Medical Journal, i, 71–5.Google Scholar
Court, J. H. (1972) The continuum model as a resolution of paradoxes in manic-depressive psychosis. British Journal of Psychiatry, 120, 133–41.Google Scholar
Crammer, J. L. (1959) Water and sodium in two psychotics. Lancet, i, 1122–6.Google Scholar
Dick, D. A. T., Dick, E. G. & Tosteson, D. D. (1969) Inhibition of adenosine triphosphatase in sheep red cells membranes by oxidized glutathione. Journal of General Physiology, 54, 123–33.Google Scholar
Hansen, O. (1972) Blood nucleoside and the nucleotide studies in mental disease. British Journal of Psychiatry, 121, 341–50.Google Scholar
Hansen, O. & Dimitrakoudi, M. (1974) The relation of blood adenosine triphosphate to changes of mood in affective disorders. British Journal of Psychiatry, 125, 268–74.Google Scholar
Hokin Naeverson, M., Spiegel, D. A. & Lewis, W. C. (1974) Deficiency of erythrocyte sodium pump activity in bipolar manic-depressive psychosis. Life Sciences, 15, 1739–48.Google Scholar
Jenner, F. A., Gjessing, C. R., Cox, J. R., Davies-Jones, A., Hullin, R. R. & Hanna, S. M. (1967) A manic-depressive psychotic with a persistent 48 hour cycle. British Journal of Psychiatry, 113, 895–910.Google Scholar
Mendels, J. & Frazer, A. (1974) Alterations in membrane activity in depression. American Journal of Psychiatry, 131, 1240–6.Google Scholar
Naylor, G. J., Dick, D. A. T., Dick, E. G. & Moody, J. P. (1974) Lithium therapy and erythrocyte membrane cation carrier. Psychopharmacologia, 37, 81–6.Google Scholar
Naylor, G. J., Buckley, D., Reid, A. H. & Stansfield, D. A. (1975) Whole blood cyclic AMP levels in a short cycle manic depressive. IRCS Medical Science: Metabolism and Nutrition: Psychiatry and Clinical Psychology, 3, 278.Google Scholar
Naylor, G. J., Dick, D. A. T., Dick, E. G., Le Poidevin, D. & Whyte, S. F. (1973) Erythrocyte membrane cation carrier in depressive illness. Psychological Medicine, 3, 502–8.Google Scholar
Reid, A. H. & Naylor, G. J. (1976) Short cycle manic-depressive psychosis in mental defectives. A clinical and physiological study. Journal of Mental Deficiency Research. (In press.)Google Scholar
Smith, E. K. M. & Samuel, P. D. (1970) Abnormalities in the sodium pump of erythrocytes from patient with hyperthyroidism. Clinical Science, 38, 49–61.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.