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Brain 5-HT function in obsessive-compulsive disorder

Prolactin responses to d-fenfluramine

Published online by Cambridge University Press:  03 January 2018

N. A. Fineberg ,
A. Roberts ,
S. A. Montgomery  and
P. J. Cowen
N. A. Fineberg*
Affiliation:
St Mary's Hospital, London
A. Roberts
Affiliation:
St Mary's Hospital, London
S. A. Montgomery
Affiliation:
St Mary's Hospital, London
P. J. Cowen
Affiliation:
Littlemore Hospital, Oxford
*
Dr P. J. Cowen, Research Unit, Littlemore Hospital, Oxford OX4 4XN
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Abstract

Background

Drugs that potentiate brain serotonin (5-HT) neurotransmission are effective in the treatment of obsessive–compulsive disorder (OCD), but it is unclear whether disturbances in brain 5-HT function play a role in the pathophysiology of OCD.

Method

We studied the prolactin response to the selective 5-HT releasing agent d-fenfluramine in 14 non-depressed, drug-free OCD patients, and 14 healthy controls matched for age and gender.

Results

The prolactin response to d-fenfluramine was significantly increased in OCD patients compared with controls.

Conclusions

The disparate results of studies of 5-HT neuroendocrine function in OCD make it unlikely that disturbances of brain 5-HT function play a central role in the pathophysiology of OCD. Increased brain 5-HT neurotransmission in non-depressed OCD subjects may represent an adaptive neurobehavioural mechanism which can be amplified to therapeutic advantage by treatment with 5-HT potentiating drugs.

Type
Papers
Information
The British Journal of Psychiatry , Volume 171 , Issue 3 , September 1997 , pp. 280 - 282
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn. revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Cowen, P. J. (1993) Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. Clinical Neuropharmacology, 16 (suppl. 3), S6–S18.Google ScholarPubMed
Deakin, J. F. W. & Graeff, F. G. (1991) 5-HT and mechanisms of defence. Journal of Psychopharmacology, 5, 305–315.CrossRefGoogle ScholarPubMed
Dinan, T. G. (1994) Glucocorticoids and the genesis of depressive illness: a psychobiological model. British Journal of Psychiatry, 164, 365–371.Google Scholar
Fineberg, N. A., Cowan, P. J., Kirk, J. W., et al (1994) Neuroendocrine responses to intravenous L-tryptophan in obsessive compulsive disorder. Journal of Affective Disorders, 32, 97–104.Google Scholar
Hewlett, W. A., Vinogradov, S., Martin, K., et al (1992) Fenfluramine stimulation of prolactin in obsessive–compulsive disorder. Psychiatry Research, 42, 81–92.Google Scholar
Hollander, E., de Caria, C. N., Nitescu, A., et al (1992) Serotonergic function in obsessive–compulsive disorder: behavioural and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. Archives of General Psychiatry, 49, 21–28.Google Scholar
Lopez-Ibor, J. J., Siaz, J. & Vinas, R. (1994) Obsessive–compulsive disorder and depression. In Psychopharmacology of Depression (eds S. A. Montgomery & T. H. Corn), pp. 185–217. Oxford: Oxford University Press.Google Scholar
Lucey, J. V., O'Keane, V., Butcher, G., et al (1992) Cortisol and prolactin responses to d-fenfluramine in non-depressed with obsessive–compulsive disorder: a comparison with depressed and healthy controls. British Journal of Psychiatry, 161, 517–521.Google Scholar
Park, S. B. G. & Cowen, P. J. (1995) Effect of pindolol on the prolactin response to d-fenfluramine. Psychopharmacology, 118, 471–474.Google Scholar
Piccinelli, M., Pini, S., Bellantuono, C., et al (1995) Efficacy of drug treatment in obsessive–compulsive disorder: a meta-analytic review. British Journal of Psychiatry, 166, 424–443.Google Scholar
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