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Categorising the Behavioural Toxicities of Antidepressants Proposals and Requirements

Published online by Cambridge University Press:  02 January 2018

James F. O'Hanlon
Affiliation:
Institute for Human Psychopharmacology, University of Limburg, Abstraat 2A, 6211 LS Maastrict, The Netherlands
Hugh Freeman*
Affiliation:
21 Montagu Square, London W1H 1RE
*
Professor Hugh Freeman, 21 Montagu Square, London W1H 1RE
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Abstract

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Type
Editorials
Copyright
Copyright © Royal College of Psychiatrists, 1995 

References

Alford, C. & Hindmarch, I. (1990) Measuring the effects of psychoactive drugs, with particular reference to antidepressants. In Microcomputers, Psychology and Medicine (eds R. West, M. Christie & J. Weinman). New York: Wiley.Google Scholar
Allen, D., Lader, M. & Curran, V. (1988) A comparative study of the interactions of alcohol with amitriptyline, fluoxetine and placebo in normal subjects. Progress in Neuropsychopharmacology and Biological Psychiatry, 12, 6380.Google Scholar
Allen, D., Curran, H. V. & Lader, M. (1991) The effects of repeated doses of clomipramine and alprazolam on physiological, performance and cognitive functions in normal subjects. European Journal of Clinical Pharmacology, 40, 355362.Google Scholar
Austin, M.-P., Ross, M., Murray, C., et al (1992) Cognitive function in major depression. Journal of Affective Disorders, 25, 2130.Google Scholar
Cohen, R. M., Weingartner, H., Smallberg, S. A., et al (1982) Effort and cognition in depression. Archives of General Psychiatry, 39, 593597.Google Scholar
Herberg, K. W. & Menke, H. (1981) Study of the effects of the Antidepressant Fluvoxamine on Driving Skills and its Interaction With Alcohol. Technical Report, Köln: TÜV Rheinland.Google Scholar
Hindmarch, I. & Kerr, J. (1992) Behavioral toxicity of antidepressants with particular reference to moclobemide. Psychopharmacology, 106, S49S55.Google Scholar
Hobi, V., Gastpar, M., Gastpar, G., et al (1982) Driving ability of depressive patients under antidepressants. Journal of International Medical Research, 10, 6581.CrossRefGoogle ScholarPubMed
Kerr, J. S., Sherwood, N. & Hindmarch, I. (1992) The comparative psychopharmacology of 5HT reuptake inhibitors. Human Psychopharmacology, 6, 313317.CrossRefGoogle Scholar
Lader, M., Melhuish, A., Freka, G., et al (1986) The effects of citralopram in single and repeated doses and with alcohol on physiological and psychological measures in healthy subjects. European Journal of Clinical Psychopharmacology, 31, 183190.CrossRefGoogle Scholar
Moon, C. A. L. & Davey, A. (1988) The efficacy and residual effects of trazodone (150 mg nocte) and mianserin in the treatment of depressed general practice patients. Psychopharmacology, 95, S7S13.Google Scholar
Nelson, R. C. (1986) Psychotherapeutic Drugs, Mental Disorders and Automobile Crashes: a Case-Control Study of 1308 Females. Unpublished Doctoral Dissertation, University of Minnesota.Google Scholar
Peselow, E. D., Corwin, J., Fieve, R. R., et al (1991) Disappearance of memory deficits in outpatient depressives responding to imipramine. Journal of Affective Disorders, 21, 173183.Google Scholar
Ramaekers, J. G., Muntjewerff, N. D. & O'Hanlon, J. F. (1995) A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance. British Journal of Clinical Pharmacology, in press.Google Scholar
Ray, W. A., Fought, R. L. & Decker, M. D. (1992) Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. American Journal of Epidemiology, 136, 873883.Google Scholar
Robbe, H. W. J. & O'Hanlon, J. F. (1995) Acute and subchronic effects of paroxetine and amitriptyline on actual driving, psychomotor performance and subjective assessments in healthy volunteers. European Neuropsychopharmacology, in press.Google Scholar
Seppälä, T. (1977) Psychomotor skills during acute and two-week treatment with mianserin (ORG GB 94) and amitriptyline, and their combined effects with alcohol. Annals of Clinical Research, 9, 6672.Google Scholar
Seppälä, T., Linnoila, M., Elonen, E., et al (1975) Effects of tricyclic antidepressants and alcohol on psychomotor skills related to driving. Clinical Pharmacology and Therapeutics, 17, 515522.Google Scholar
Seppälä, T., Linnoila, M. & Mattila, M. J. (1978) Psychomotor skills in depressed outpatients treated with L-tryptophan, doxepin or chlorimipramine. Annals of Clinical Research, 10, 214221.Google Scholar
Seppälä, T., Strömberg, C. & Bergman, J. (1984) Effects of zimelidine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol: a placebo-controlled crossover study. European Journal of Clinical Pharmacology, 27, 181189.Google Scholar
Sherwood, N. & Hindmarch, I. (1993) A comparison of five commonly prescribed antidepressants with particular reference to their behavioural toxicity. Human Psychopharmacology, 8, 417422.Google Scholar
Siegfried, K. & O'Connolly, M. (1986) Cognitive and psychomotor effects of different antidepressants in the treatment of old age depression. International Psychopharmacology, 1, 231243.Google Scholar
Vermeeren, A., De Gier, J. J. & O'Hanlon, J. F. (1994) Methodological Guidelines for Experimental Research on Medicinal Drugs Affecting Driving Performance: an International Expert Survey. Maastricht: University of Limburg Institute for Human Psychopharmacology. Techn. Rep. 93-27, ISBN 90-5147-021-5.Google Scholar
Weckowicz, T. E., Tam, C.-N.I., Mason, I., et al (1978) Speed in test performance of depressed patients. Journal of Abnormal Psychology, 87, 578582.Google Scholar
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