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Changes During Weeks in Effects of Tricyclic Drugs on the Human Sleeping Brain

Published online by Cambridge University Press:  29 January 2018

D. L. F. Dunleavy ,
Vlasta Brezinova ,
Ian Oswald ,
A. W. Maclean  and
M. Tinker
D. L. F. Dunleavy
Affiliation:
Department of Psychiatry, University of Edinburgh, Edinburgh, EHZO 5HF, Scotland
Vlasta Brezinova
Affiliation:
Department of Psychiatry, University of Edinburgh, Edinburgh, EHZO 5HF, Scotland
Ian Oswald
Affiliation:
Department of Psychiatry, University of Edinburgh, Edinburgh, EHZO 5HF, Scotland
A. W. Maclean
Affiliation:
Department of Psychiatry, University of Edinburgh, Edinburgh, EHZO 5HF, Scotland
M. Tinker
Affiliation:
Western General Hospital, Crewe Road, Edinburgh, 4, Scotland
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Extract

The tricyclic antidepressants are established in therapy but not in mode of action. Effects on mouse or rat brain of single and relatively enormous doses provide the basis for theories. Yet it may be inferred that the clinical use of tricyclic antidepressants relies upon an induction of brain changes on a time-scale of weeks. Studies of tricyclic drug actions upon human brain physiology are as scanty as are easily-measurable human brain functions. Electrophysiological techniques, however, can conveniently be applied during one principal brain-state, namely sleep, when there is a relative freedom from uncontrollable extraneous variables.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 120 , Issue 559 , June 1972 , pp. 663 - 672
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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